DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Crk and dock

DIOPT Version :9

Sequence 1:	NP_651908.1	Gene:	Crk / 43775	FlyBaseID:	FBgn0024811	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_001259845.1	Gene:	dock / 33262	FlyBaseID:	FBgn0010583	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	185	Identity:	45/185 - (24%)
Similarity:	82/185 - (44%)	Gaps:	51/185 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 VIGKFDFVGSDQDDLPFQRGEVLTIVRK--DEDQWWTARNSSGKIGQIPVPYIQQYDDYM----- 168
            |:..:.|..::..:|.|::|:.|.||.:  .:..|:.|||:.|::|.:|..|:|:.:||:
  Fly   329 VVALYSFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARNNQGQVGLVPRNYLQELNDYLATPYR 393

  Fly   169 ----------------------DEDAIDK----NEPSISGSSNVFESTLKRTDLNRKLPAYARVK 207
                                  ..|::::    |:|:...|....|    |.:|..|...|..:.
  Fly   394 NASASAGNGNGGGSNGGAGGGGGNDSMERRNEGNKPAAQSSGQPIE----RPNLAGKSWYYGAIT 454

  Fly   208 QSR---VPNAYDKTALKLEIGD-IIKVTKTNINGQWEGELN--GKNGHFPFTHVE 256
            :|:   |.|.:...      || :|:.::||: |.:...|.  |:|.||. .|||
  Fly   455 RSQCDTVLNGHGHD------GDFLIRDSETNM-GDYSVSLKAPGRNKHFR-VHVE 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Crk	NP_651908.1	SH2_CRK_like	4..108	CDD:198180
		SH3_CRK_N	109..163	CDD:212692	16/53 (30%)
		SH3_CRK_C	201..257	CDD:212693	18/62 (29%)
dock	NP_001259845.1	SH3_Nck_1	154..204	CDD:212699
		SH3_Nck_2	256..308	CDD:212700
		SH3_Nck_3	328..383	CDD:212701	16/53 (30%)
		SH2_Nck_family	446..538	CDD:198196	19/64 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19969
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010