Protein Alignment Crk and ced-2

DIOPT Version :9

• Sequence 1: NP_651908.1
• Gene: Crk / 43775
• FlyBaseID: FBgn0024811
• Length: 271
• Species: Drosophila melanogaster
• Sequence 2: NP_500105.1
• Gene: ced-2 / 176968
• WormBaseID: WBGene00000416
• Length: 279
• Species: Caenorhabditis elegans
• Alignment Length: 273
• Identity: 97/273 - (35%)
• Similarity: 148/273 - (54%)
• Gaps: 23/273 - (8%)

  Fly     4 FDVSDRNSWYFGPMSRQDATEVLMNER-ERGVFLVRDSNSIAGDYVLCVR---EDTKVSNYIINK 64
            ||..:..|:||..|||::|.::|...: ..|.||:||| |..|:|.|.||   |...|.:|:|.:
 Worm     6 FDPFEWRSFYFPGMSREEAHKLLGEPQVSIGTFLMRDS-SRPGEYSLTVREADEGNAVCHYLIER 69

  Fly    65 VQQQDQ----IVYRIGDQSFDNLPKLLTFYTLHYLDTTPL----KRPACRRVEKVIGKFDFVGSD 121
            .:.::.    ...:|.:|||.::|.||..:.:..|....|    |:|.   :|.|:|.|.|.|..
 Worm    70 GEPKEDGTAAAGVKIANQSFPDIPALLNHFKMRVLTEASLLAAYKKPI---IEVVVGTFKFTGER 131

  Fly   122 QDDLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQ-QYDDYMDEDAIDKNEPSI---SG 182
            :.||||::||.|.|:.|....||.|||:.|..|.:|..|:| |.:.:.|..:...::.||   .|
 Worm   132 ETDLPFEQGERLEILSKTNQDWWEARNALGTTGLVPANYVQIQMEFHNDRTSKGASQSSIGSSGG 196

  Fly   183 SSNVFESTLKRTD---LNRKLPAYARVKQSRVPNAYDKTALKLEIGDIIKVTKTNINGQWEGELN 244
            .:..|.|....:|   |..:|||.|:|...|||||||.|.|:::.|..:.||:...||.::.||:
 Worm   197 GAERFSSASTSSDNIELQPRLPAKAKVTFDRVPNAYDPTQLRVKKGQTVLVTQKMSNGMYKAELD 261

  Fly   245 GKNGHFPFTHVEF 257
            |:.|..|.|::.|
 Worm   262 GQIGSVPHTYLRF 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Crk	NP_651908.1	SH2_CRK_like	4..108	CDD:198180	37/115 (32%)
		SH3_CRK_N	109..163	CDD:212692	25/54 (46%)
		SH3_CRK_C	201..257	CDD:212693	24/55 (44%)
ced-2	NP_500105.1	SH2	6..116	CDD:301589	36/110 (33%)
		SH3_Nck_3	120..173	CDD:212701	23/52 (44%)
		SH3	218..274	CDD:302595	24/55 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158504
Domainoid	1	1.000	47	1.000	Domainoid score	I8122
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81850
Inparanoid	1	1.050	144	1.000	Inparanoid score	I3035
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52661
OrthoDB	1	1.010	-	-		D1414461at2759
OrthoFinder	1	1.000	-	-		FOG0003539
OrthoInspector	1	1.000	-	-		oto20428
orthoMCL	1	0.900	-	-		OOG6_105421
Panther	1	1.100	-	-	LDO	PTHR19969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5267
SonicParanoid	1	1.000	-	-		X2415
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.900