Protein Alignment Crk and Fgr

DIOPT Version :10

• Sequence 1: NP_651908.1
• Gene: Crk / 43775
• FlyBaseID: FBgn0024811
• Length: 271
• Species: Drosophila melanogaster
• Sequence 2: NP_034338.3
• Gene: Fgr / 14191
• MGIID: 95527
• Length: 517
• Species: Mus musculus
• Alignment Length: 208
• Identity: 50/208 - (24%)
• Similarity: 87/208 - (41%)
• Gaps: 49/208 - (23%)

  Fly     5 DVSDRNSWYFGPMSRQDA-TEVLMNERERGVFLVRDSNSIAGDYVLCVRE-DTKVSNYIIN-KVQ 66
            |......||||.:||:|| .::|.:...:|.||:|:|.:..|.|.|.:|: |....::|.: |::
Mouse   125 DSIQAEEWYFGKISRKDAERQLLSSGNPQGAFLIRESETTKGAYSLSIRDWDQNRGDHIKHYKIR 189

  Fly    67 QQDQIVYRIGDQS-FDNLPKLLTFYT-----LHYLDTTP--LKRPACRRVEKVIGKFDFVGSDQD 123
            :.|...|.|..:: ||::..|:..|.     |.||.|.|  ..:|....:.|     |....|::
Mouse   190 KLDTGGYYITTRAQFDSIQDLVRHYMEVNDGLCYLLTAPCTTTKPQTLGLAK-----DAWEIDRN 249

  Fly   124 DLPFQR-------GEVLTIVRKDEDQWWTARNSSGKIG--------QIPVPYIQQ--------YD 165
            .:..:|       |:|          |....|.|.|:.        ..|..::::        :|
Mouse   250 SIALERRLGTGCFGDV----------WLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKLLRHD 304

  Fly   166 DYMDEDAIDKNEP 178
            ..:...|:...||
Mouse   305 KLVQLYAVVSEEP 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Crk	NP_651908.1	SH2_CRK_like	4..108	CDD:198180	35/113 (31%)
		SH3_CRK_N	109..163	CDD:212692	11/68 (16%)
		SH3_CRK_C	201..257	CDD:212693
Fgr	NP_034338.3	SH3	68..125	CDD:473055	50/208 (24%)
		Interaction with CLNK. /evidence=ECO:0000269|PubMed:16439675	102..103
		SH2_Src_Fgr	128..228	CDD:198230	32/99 (32%)
		Protein Kinases, catalytic domain	255..502	CDD:473864	12/73 (16%)