Protein Alignment Crk and Fer

DIOPT Version :10

• Sequence 1: NP_651908.1
• Gene: Crk / 43775
• FlyBaseID: FBgn0024811
• Length: 271
• Species: Drosophila melanogaster
• Sequence 2: NP_001033086.2
• Gene: Fer / 14158
• MGIID: 105917
• Length: 823
• Species: Mus musculus
• Alignment Length: 240
• Identity: 55/240 - (22%)
• Similarity: 97/240 - (40%)
• Gaps: 76/240 - (31%)

  Fly     2 DTFDVSDR----NSWYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYII 62
            |...|.:|    :.||.|.:.|.:|.|:|   :::|.||||:|:...|:|||.|..|.:..::||
Mouse   447 DVISVGERPLAEHDWYHGAIPRIEAQELL---KQQGDFLVRESHGKPGEYVLSVYSDGQRRHFII 508

  Fly    63 NKVQQQDQIVYRIGDQSFDNLPKLLTFYTLHYLDTTPLKRPACRRVEKVIGKFDFVGSDQDDLPF 127
            ..|..    :||.....|.|:|:|:.    |:.:|           ::||.|
Mouse   509 QFVDN----LYRFEGTGFSNIPQLID----HHFNT-----------KQVITK------------- 541

  Fly   128 QRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQYDDYMDEDAIDKNEPSISGSSN---VFES 189
             :..|:.:....:|:.|...:....:|:                        :.|..|   |::.
Mouse   542 -KSGVVLLNPIPKDKKWVLNHEDVSLGE------------------------LLGKGNFGEVYKG 581

  Fly   190 TLK-RTDLNRK-----LPAYARVK---QSRVPNAYDKTALKLEIG 225
            ||| :|.:..|     ||...::|   ::::...||...:...||
Mouse   582 TLKDKTPVAIKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIG 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Crk	NP_651908.1	SH2_CRK_like	4..108	CDD:198180	32/107 (30%)
		SH3_CRK_N	109..163	CDD:212692	7/53 (13%)
		SH3_CRK_C	201..257	CDD:212693	6/28 (21%)
Fer	NP_001033086.2	Important for interaction with membranes containing phosphoinositides. /evidence=ECO:0000250	1..300
		F-BAR_Fer	5..238	CDD:153370
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..408
		SH2_Fps_family	454..539	CDD:198224	31/106 (29%)
		Protein Kinases, catalytic domain	567..817	CDD:473864	16/84 (19%)