Protein Alignment Crk and CRKL

DIOPT Version :10

• Sequence 1: NP_651908.1
• Gene: Crk / 43775
• FlyBaseID: FBgn0024811
• Length: 271
• Species: Drosophila melanogaster
• Sequence 2: NP_005198.1
• Gene: CRKL / 1399
• HGNCID: 2363
• Length: 303
• Species: Homo sapiens
• Alignment Length: 304
• Identity: 136/304 - (44%)
• Similarity: 186/304 - (61%)
• Gaps: 48/304 - (15%)

  Fly     4 FDVSDRNSWYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQ 68
            ||.|||::||.||:|||:|...|..:| .|:||||||::..|||||.|.|:::||:||||.:..:
Human     6 FDSSDRSAWYMGPVSRQEAQTRLQGQR-HGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNR 69

  Fly    69 DQIVYRIGDQSFDNLPKLLTFYTLHYLDTTPLKRPACR-------------------RVEKVIGK 114
            .   ::||||.||:||.||.||.:||||||.|..||.|                   .:|.|...
Human    70 R---FKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTL 131

  Fly   115 FDFVGSDQDDLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQY--------------D 165
            :||.|:|.:||||::||:|.|:.|.|:|||:|||..|::|.|||||:::.              :
Human   132 YDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSN 196

  Fly   166 DY-MDEDAIDKNE-------PSISGSSNVFESTLKRTDLNRKLPAYARVKQSRVPNAYDKTALKL 222
            .| :.|.|....:       |::|||.....:.|..|   :..|.:|:..|.|||.|||||||.|
Human   197 SYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPST---QNGPVFAKAIQKRVPCAYDKTALAL 258

  Fly   223 EIGDIIKVTKTNINGQWEGELNGKNGHFPFTHVEFVDDCDLSKN 266
            |:|||:|||:.|||||||||:||:.|.||||||:..|..:..:|
Human   259 EVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPDEN 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Crk	NP_651908.1	SH2_CRK_like	4..108	CDD:198180	57/122 (47%)
		SH3_CRK_N	109..163	CDD:212692	29/53 (55%)
		SH3_CRK_C	201..257	CDD:212693	39/55 (71%)
CRKL	NP_005198.1	SH2_CRK_like	6..106	CDD:198180	57/103 (55%)
		SH3_CRK_N	126..180	CDD:212692	29/53 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	184..234		9/52 (17%)
		SH3_CRK_C	237..293	CDD:212693	39/55 (71%)