Protein Alignment Crk and Crkl

DIOPT Version :9

• Sequence 1: NP_651908.1
• Gene: Crk / 43775
• FlyBaseID: FBgn0024811
• Length: 271
• Species: Drosophila melanogaster
• Sequence 2: NP_031790.2
• Gene: Crkl / 12929
• MGIID: 104686
• Length: 303
• Species: Mus musculus
• Alignment Length: 294
• Identity: 130/294 - (44%)
• Similarity: 178/294 - (60%)
• Gaps: 42/294 - (14%)

  Fly     4 FDVSDRNSWYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQ 68
            ||.|||::||.||::||:|...|..:| .|:||||||::..|||||.|.|:::||:||||.:..:
Mouse     6 FDSSDRSAWYMGPVTRQEAQTRLQGQR-HGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNR 69

  Fly    69 DQIVYRIGDQSFDNLPKLLTFYTLHYLDTTPLKRPACRRVEKVIGK------------------- 114
            .   ::||||.||:||.||.||.:||||||.|..||.|.....:|.
Mouse    70 R---FKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPVGSVSAPNLPTAEENLEYVRTL 131

  Fly   115 FDFVGSDQDDLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQY--------------D 165
            :||.|:|.:||||::||:|.|:.|.|:|||:|||..|::|.|||||:::.              :
Mouse   132 YDFPGNDAEDLPFKKGELLVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSN 196

  Fly   166 DY-MDEDAIDKNEPSISGSSNVFEST----LKRTDLNRKLPAYARVKQSRVPNAYDKTALKLEIG 225
            .| :.|.|....:|..:.......||    :......:..|.:|:..|.|||.|||||||.||:|
Mouse   197 SYGIPEPAHAYAQPQTTTPLPTVASTPGAAINPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVG 261

  Fly   226 DIIKVTKTNINGQWEGELNGKNGHFPFTHVEFVD 259
            ||:|||:.|||||||||:||:.|.||||||:..|
Mouse   262 DIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFD 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Crk	NP_651908.1	SH2_CRK_like	4..108	CDD:198180	56/103 (54%)
		SH3_CRK_N	109..163	CDD:212692	28/72 (39%)
		SH3_CRK_C	201..257	CDD:212693	39/55 (71%)
Crkl	NP_031790.2	SH2_CRK_like	6..106	CDD:198180	56/103 (54%)
		SH3_CRK_N	126..180	CDD:212692	27/53 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	184..203		1/18 (6%)
		SH3_CRK_C	237..293	CDD:212693	39/55 (71%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835200
Domainoid	1	1.000	82	1.000	Domainoid score	I8402
eggNOG	1	0.900	-	-		E1_KOG4792
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	241	1.000	Inparanoid score	I3321
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52661
OrthoDB	1	1.010	-	-		D1414461at2759
OrthoFinder	1	1.000	-	-		FOG0003539
OrthoInspector	1	1.000	-	-		otm42455
orthoMCL	1	0.900	-	-		OOG6_105421
Panther	1	1.100	-	-	LDO	PTHR19969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5267
SonicParanoid	1	1.000	-	-		X2415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800