DRSC/TRiP Functional Genomics Resources

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Protein Alignment Crk and Abl2

DIOPT Version :10

Sequence 1:NP_651908.1 Gene:Crk / 43775 FlyBaseID:FBgn0024811 Length:271 Species:Drosophila melanogaster
Sequence 2:NP_033725.2 Gene:Abl2 / 11352 MGIID:87860 Length:1182 Species:Mus musculus


Alignment Length:222 Identity:54/222 - (24%)
Similarity:87/222 - (39%) Gaps:63/222 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 DRNSWYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQDQIV 72
            :::|||.||:|| .|.|.|::....|.||||:|.|..|...:.:|.:.:|.:|.||..  .|..|
Mouse   169 EKHSWYHGPVSR-SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT--TDSKV 230

  Fly    73 YRIGDQSFDNLPKLLTFY---------TLHYLDTTPLKRPACRR-----VEKVIGKFDFVGSDQD 123
            |...:..|..|.:|:..:         ||||      ..|.|.:     |..:..|::...:|  
Mouse   231 YVTAESRFSTLAELVHHHSTVADGLVTTLHY------PAPKCNKPTVYGVSPIHDKWEMERTD-- 287

  Fly   124 DLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQYDDYMDEDAIDKNEPSISGSSNVFE 188
                     :|:..|         ...|:.|::.|...::|                  |..|..
Mouse   288 ---------ITMKHK---------LGGGQYGEVYVGVWKKY------------------SLTVAV 316

  Fly   189 STLKR--TDLNRKLPAYARVKQSRVPN 213
            .|||.  .::...|...|.:|:.:.||
Mouse   317 KTLKEDTMEVEEFLKEAAVMKEIKHPN 343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CrkNP_651908.1 SH2_CRK_like 4..108 CDD:198180 35/113 (31%)
SH3_CRK_N 109..163 CDD:212692 7/53 (13%)
SH3_CRK_C 201..257 CDD:212693 4/13 (31%)
Abl2NP_033725.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..42
CAP 2..106
SH3_Abl 111..164 CDD:212784
SH2_ABL 169..262 CDD:198189 33/101 (33%)
PTKc_Abl 281..543 CDD:270645 17/101 (17%)
Kinase activation loop. /evidence=ECO:0000250 427..451
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 612..642
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..674
Nuclear localization signal. /evidence=ECO:0000255 659..661
F-actin-binding 695..930
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 765..796
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 809..858
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1059
F-actin-binding 1020..1182
FABD 1063..1182 CDD:197885
Blue background indicates that the domain is not in the aligned region.

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