DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31998 and PRRT4

DIOPT Version :9

Sequence 1:	NP_726548.1	Gene:	CG31998 / 43774	FlyBaseID:	FBgn0051998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_001167635.1	Gene:	PRRT4 / 401399	HGNCID:	37280	Length:	899	Species:	Homo sapiens

Alignment Length:	857	Identity:	161/857 - (18%)
Similarity:	248/857 - (28%)	Gaps:	333/857 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   495 TLRQPPSSPIVLIEKSTSNEEIIDADAPSVVSPNINHSKYHPGQLEYYENATAGTTP-------- 551
            ||..||.|    :|:..|        :||.:.|        ...|.:...||....|
Human   258 TLSLPPYS----LERKLS--------SPSPLDP--------AASLSFASIATTSLDPTVPISGPD 302

  Fly   552 --SAAAAIGDVSATSFSYATTNAGQPGHTGKTTDAIREL--GTGVPDQNP------IGAAAAATV 606
              |..|::|:.|           ||| ..|..:.::.||  ..|.|.:.|      ...|..|..
Human   303 DLSPPASLGNPS-----------GQP-ECGPGSCSVGELPEREGQPPEAPRPLFFLTLEADWAEA 355

  Fly   607 HTTWAWAWNIHIYLSVVLFTILSVYSLYKLLTYNKLTHLFAQAYFVC---------INLILIMIC 662
            ...|..||..|:|....||.::::.:|..|          |...:.|         ::|:|:...
Human   356 RARWGLAWEAHVYGVGALFGLVALLALLAL----------ALLPWRCPPGAPCLALLDLLLLSAG 410

  Fly   663 ILRIFFLCFDAYNVHGSFNLFTSELFLNLPSTFLTVAFSVLILFLFLKSLNHKNNRYSALIRPL- 726
            ..|.|.|.:|||. |..          .||:          :.:|.|:.|            ||
Human   411 TTRAFPLFYDAYG-HRD----------RLPA----------LAWLLLQDL------------PLP 442

  Fly   727 TVVVGCGVHVVLCITLHYVESYTLKNHHLYFQQQQQQQYFRRQQLYNQQGQPTATMSPSAILPPP 791
            .:..|.|   :.|:.|                                            ..|.|
Human   443 CLAAGLG---LACLLL--------------------------------------------ARPRP 460

  Fly   792 PRVLTLICQIIYIFICLSLGLLYLYIYRILKRILRSKSQNYIHGYQNLSYAIHITIATALLFVLL 856
            ||..|.:..:    :.|.|||       .....|.|.:...:...:..|..:|..:|..|..:||
Human   461 PRCPTGLAAL----LLLGLGL-------AAAAALGSAAHRPLRPLRLASRGLHAFLAAFLSGLLL 514

  Fly   857 AALQIFGAIYISCRHTSIVDVDWLQWGYQFSLRLIEIAIITLMSWVAGLKTSVEHDSLSAVAGDV 921
            |         :||            ||                                   |..
Human   515 A---------LSC------------WG-----------------------------------GRR 523

  Fly   922 RMIGSGMGAYGQDGGTP--------------NNAIREKHVGNGTGTHNSNVTNF-FLPCTSSSSQ 971
            |..|:.:|..|..|.||              ..|.|...|....|..:..:..: .|.......|
Human   524 RRAGAPLGGSGFKGATPLPQGRSPFAPRESWRRAARTAPVAGTFGLLSGALQGYEVLHALGYGGQ 588

  Fly   972 EHFETDYPAVCNANTNLHTYTMRTGKLIYDDSYALNSMGPTTATTSNARPCEYQL--QEPMYQRP 1034
            ...|..:|...      ....:|.|::......||..:.|...:......|..:|  ..|.:..|
Human   589 SGLEGPWPWWA------FQLGLRLGEVGVALPLALLGLYPALCSPRVPPRCWAKLFRLSPGHAAP 647

  Fly  1035 Y----------DTGSIGSTLNQ-QHQLNQMRFQEHPTYMSTDYMTDSGPD---------HYE--- 1076
            .          |...:||.:.: ..:|.|:.....|           |||         .:|
Human   648 LLPGGWVTGPPDKEPLGSAIARGDAELLQLCALAGP-----------GPDLLLQGGGCRGFEGAA 701

  Fly  1077 -NPNFSLHSTATEQKRRDYDQNEVSFNSNSGA-LQQQVELLQNNCYSEPLEQENKRYEFNIFERP 1139
             ||..|..|:...    ||   .|.|...|.. |::.:|  :..| ||.|...      .:|:.|
Human   702 ANPAPSPASSPCS----DY---TVDFRPPSPINLRRSIE--EALC-SEALLAP------GLFQGP 750

  Fly  1140 VFKEK----SVHNVQSNSECIQDRQKITNGRKKKFNGALDRHVFESKTHERRSSNSANSCSSSNL 1200
            .|::.    .::...|..         |.||..:                 ||..::...:...|
Human   751 AFEDALPGLGLYRTASLG---------TGGRASE-----------------RSGEASGPAAPPEL 789

  Fly  1201 GGGGRFGSFNSFERGYFNGVCKSGTISSIAKAGALGR--------TLESPIASAETQRIVANGS- 1256
            ...|.:.:.:|...|.|.|:.:..  ||:....:..|        .|..|..|..:..:.|:||
Human   790 PSPGAWPAGSSVSSGSFCGLSRDS--SSMLLCSSPDRPPRCPLVCVLSPPRPSGSSPSLPASGSY 852

  Fly  1257 QTLGIPDKDRPQ 1268
            |.|..|.:|.|:
Human   853 QALSPPSRDSPE 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31998	NP_726548.1	EXS	610..>724	CDD:296120	25/122 (20%)
PRRT4	NP_001167635.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..152
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..340		12/56 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	769..797		7/44 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	839..869		9/26 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28K70
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900