DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCD and PXA1

DIOPT Version :9

Sequence 1:	NP_001245409.1	Gene:	ABCD / 43772	FlyBaseID:	FBgn0039890	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_015178.1	Gene:	PXA1 / 855956	SGDID:	S000006068	Length:	870	Species:	Saccharomyces cerevisiae

Alignment Length:	759	Identity:	241/759 - (31%)
Similarity:	378/759 - (49%)	Gaps:	127/759 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 IPYVKNVNTTS-------SVRTQKGKTNGQLSPSTRDSSEED---FKLAEAEKLLVAQQLKKKAT 97
            ||.|:.|:..|       :...:|.:....:.|...|..|.|   ||..|.|:...:|....|
Yeast   124 IPEVELVDRQSPDDNKFMNATDKKKRKRIFIPPKDNDVYEHDKFLFKNVELERAKNSQLFYSK-- 186

  Fly    98 NNLVEPGLNKEFLKHLQMLAKIMIPQAFCYETGLLSVHTFCLISRTFLSIYVAALEGALVKFIVR 162
                       ||..:.:|:||:||..|.....||:...|.|:.||:||::||.|:|.:||.|:.
Yeast   187 -----------FLNQMNVLSKILIPTVFDKNFLLLTAQIFFLVMRTWLSLFVAKLDGQIVKNIIA 240

  Fly   163 KDIKQFALVLLKWFGIAIPATFVNSMIRFLESKLSLAFRTRLVRHSYRLYF-KNQNYYRV----- 221
            ...:.|...|..||.||:||::.||.|:.|:.||||.||..|.|:.:.:|. |...:|::
Yeast   241 GRGRSFLWDLGCWFLIAVPASYTNSAIKLLQRKLSLNFRVNLTRYIHDMYLDKRLTFYKLIFDAK 305

  Fly   222 -SNLDGRIENADHRLTEDISVFANSVAHLYSSLTKPCFDLMLIGLALMRSSKKMKANIITGPALS 285
             ||  ..|:|.|:.:|.|::.|.::...:::::.||..||:...:.|       :.|:.|
Yeast   306 ASN--SVIKNIDNSITNDVAKFCDATCSVFANIAKPVIDLIFFSVYL-------RDNLGT----- 356

  Fly   286 IGVIA------LTAHILRIVSPKFGQLVSEEANRYGYLRHIHSRIITNAEEIAFYGGHKVEMQQL 344
            :||..      :|..|||..:|..|:|..|.:...|...:.|..:|.|:||||||.|..||..::
Yeast   357 VGVAGIFVNYFITGFILRKYTPPLGKLAGERSASDGDYYNYHLNMINNSEEIAFYQGTAVERTKV 421

  Fly   345 RQAYNRLVNQMTTIFNQKLWFIMLEQFFMKYVWSGTGMIMVSLPILTGSDVGLGTVPNTAISESR 409
            ::.|:.|:.:|..:...|..:.|||.:.:||.|||.|.:..|:||:      :.|:.....||.:
Yeast   422 KELYDVLMEKMLLVDKVKFGYNMLEDYVLKYTWSGLGYVFASIPIV------MSTLATGINSEEK 480

  Fly   410 VSERTQYLTTARNLLISAADAIERLMSSYKEIVSLAGYTFRVAGMMDVFEE------------TA 462
              ...:::...| |::|.|||..|||.|.|:|..|.|||.|:..::.|...            :.
Yeast   481 --NMKEFIVNKR-LMLSLADAGSRLMHSIKDISQLTGYTNRIFTLLSVLHRVHSLNFNYGAVPSI 542

  Fly   463 LGVYCKTSVMESNQSNGIIEFRNGKPIAKGRIIYSDDPKNMS-ISLRAVPVVTPNCDI-----VV 521
            |.:..:.:   |..||.:....|.:...:|.|     .:|.: |.|..:.|:.|:...     ::
Yeast   543 LSIRTEDA---SRNSNLLPTTDNSQDAIRGTI-----QRNFNGIRLENIDVIIPSVRASEGIKLI 599

  Fly   522 PKLT----LCIEP-------------------------GVHLLITGPNGCGKSSLFRILSGLWPI 557
            .|||    |.|:|                         |..|||.|||||||||:.||::.:||:
Yeast   600 NKLTFQIPLHIDPITSKSNSIQDLSKANDIKLPFLQGSGSSLLILGPNGCGKSSIQRIIAEIWPV 664

  Fly   558 Y--AGELHIPRPVKDVPCMFYIPQRPYMSI-GSLCDQIIYPDTREDMKRKHITENELRSILKMVS 619
            |  .|.|.||....    :|:|||:||.|. |:|.||||||.:.::...:...:.||..||..|.
Yeast   665 YNKNGLLSIPSENN----IFFIPQKPYFSRGGTLRDQIIYPMSSDEFFDRGFRDKELVQILVEVK 725

  Fly   620 LEHIAQR----DSFDVVRDWKDILSGGEKQRMAIARLFYHRPRYALLDECTSAVSIDVESSIYEI 680
            |:::.:|    ...|.:.||||:||||||||:..||:.:|:|.|.:|||.|:|:|:|:|..::.:
Yeast   726 LDYLLKRGVGLTYLDAIADWKDLLSGGEKQRVNFARIMFHKPLYVVLDEATNAISVDMEDYLFNL 790

  Fly   681 AKGMGITLLTITHRPTLWKYHTHILEF--DGLGNWQFRKMNSDE 722
            .|......::|:.||||.|||..:||.  :..|.||.:.:.:||
Yeast   791 LKRYRFNFISISQRPTLIKYHEMLLEIGENRDGKWQLQAVGTDE 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCD	NP_001245409.1	3a01203	75..715	CDD:273360	230/711 (32%)
PXA1	NP_015178.1	3a01203	113..827	CDD:273360	238/750 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345867
Domainoid	1	1.000	160	1.000	Domainoid score	I861
eggNOG	1	0.900	-	-		E1_COG4178
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I444
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53776
OrthoFinder	1	1.000	-	-		FOG0000393
OrthoInspector	1	1.000	-	-		otm46586
orthoMCL	1	0.900	-	-		OOG6_100236
Panther	1	1.100	-	-	LDO	PTHR11384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X313
TreeFam	0	0.000	Not matched by this tool.
	11	10.800