DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCD and PXA2

DIOPT Version :9

Sequence 1:	NP_001245409.1	Gene:	ABCD / 43772	FlyBaseID:	FBgn0039890	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_012733.1	Gene:	PXA2 / 853647	SGDID:	S000001671	Length:	853	Species:	Saccharomyces cerevisiae

Alignment Length:	787	Identity:	231/787 - (29%)
Similarity:	399/787 - (50%)	Gaps:	134/787 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 FTKHAFSYALVTSAILALTIKVTIPYVKNVNTTSSVRTQKGKTNGQLSPSTRDSSEEDFKLAEAE 84
            :.||..:  |:.|:.:.|.:..    :.|.|::||    ..||:.:.|.||   ..|:.|:.|.:
Yeast     9 YQKHRVN--LLRSSYIILLLAT----LYNSNSSSS----NNKTDKKDSEST---VLENKKIEEGK 60

  Fly    85 KLLVAQQ-----------LKKKATNNLVEPG---LNKEFLKH---------LQMLAKIMIPQAFC 126
            :..|.::           :.|.:|::  |.|   ::||...:         :..|.|:::....|
Yeast    61 ETAVDREEDESSKEELTIVSKHSTDS--EDGAIIIDKESKTNHKGGERKGKVDFLFKLLLHDKKC 123

  Fly   127 YETGLLSVHTFCLIS-RTFLSIYVAALEGALVKFIVRKDIKQFALVLL-KWFGIAIPATFVNSMI 189
            .   :|.:....|:: ||.||:.||.|:|.||..:||.....|..:|| ||..:.|||:|:||:|
Yeast   124 L---ILFITQAILLNIRTLLSLRVATLDGQLVSTLVRAQYANFTKILLGKWMILGIPASFINSLI 185

  Fly   190 RFLESKLSLAFRTRLVRHSYRLYFKNQN-YYRVSNLDGRIENADHRLTEDISVFANSVAHLYSSL 253
            .:.....::....::.......|..|.: :|.|::.:...|..|: ||:||..|:.:.:.|.:.|
Yeast   186 SYTTKLCAVTINRKVSDFLLSKYLSNHHTFYSVASAESVSEIQDN-LTKDIYTFSMNSSLLLNQL 249

  Fly   254 TKPCFDLMLIGLALMRSSKKMKANIITGPALSIGVIALTAH-ILRIVSPKFGQLVSEEANRYGYL 317
            .||..||:|....|:.|:    .:::....|::|:|...:: :|:::.|.|.:|....|:...:.
Yeast   250 LKPMLDLILCSFKLLTSN----TSVMGEGTLALGLIVYASNSLLKLIQPNFTRLTMASASLESWF 310

  Fly   318 RHIHSRIITNAEEIAFYGGHKVEMQQLRQAYNRLVNQMTTIFNQKLWFIMLEQFFMKYVWSGTGM 382
            |.:||.:.::.||||...|.|.|::.:..::.|||..:......:..:.:...|.:||.|...|:
Yeast   311 RSLHSNLHSSNEEIALLRGQKRELENVDYSFYRLVLFLNREIKARAIYDVATAFVIKYTWGAAGL 375

  Fly   383 IMVSLPILTGSDVGLGTVPNTAISESRVSERTQYLTTARNLLISAADAIERLMSSYKEIVSLAGY 447
            ::.|:||...:.....|:   .:.|.. ::.|....|.|.||::|:.:|.|.:...:.|..|.|.
Yeast   376 VLCSIPIFFKNKPSEDTL---QLKEPG-NDMTADFITNRRLLVTASSSIGRFVELKRNIQQLRGI 436

  Fly   448 TFRVAGMMDVFEETALGVYCKTSVMESNQSNGIIEFRNG----KPIAKGRIIYSDDPKNMSISLR 508
            ..|:                       |:.|.:::...|    :|..:..|:..||.:   |...
Yeast   437 RLRL-----------------------NKFNDLLDANKGDDEKEPRDERCIVEYDDSR---IKFE 475

  Fly   509 AVPVVTPNCDIVVPKLTLCIEPGVHLLITGPNGCGKSSLFRILSGLWPIYA-------GELHIPR 566
            .:|::||...::||:|:..::.|.||||.||||||||||||||.|||||.|       .:|.:||
Yeast   476 NIPLITPANQVLVPELSFDLKHGNHLLIIGPNGCGKSSLFRILGGLWPIRATPNKNHQSKLIMPR 540

  Fly   567 PVKDVPC-MFYIPQRPYM-SIGSLCDQIIYPDTREDMKRKH-----ITENELRSILKMVSLEH-- 622
            ...|..| :||:|||||| :..:..:||||||:.|..|.::     :.:.:|..||:::.||.
Yeast   541 RTVDRDCAIFYLPQRPYMGNRSTFREQIIYPDSIEQFKERYHNDYDLGDADLIKILQLLDLEDLV 605

  Fly   623 -------IAQ-----------------------RDSFDVVRDWKDILSGGEKQRMAIARLFYHRP 657
                   :||                       ||:|.:||:|.:.|:.|.:||:|:||::||:|
Yeast   606 TENMSLLLAQRTSKNDSQQLSTEDNQSPCAIKVRDAFSIVRNWSEELTIGVQQRLAMARMYYHKP 670

  Fly   658 RYALLDECTSAVSIDVESSIYEIAKGMGITLLTITHRPTLWKYHTHILEFDGLGNWQFRKMNSDE 722
            ::|:||||||||:.::|..:||.|:..||:|:::.||.:||.:|.::|:|||.|.:||...|..|
Yeast   671 KFAVLDECTSAVAPEMEQRMYENAQNFGISLISVCHRTSLWHFHNYLLKFDGKGGYQFGPFNPKE 735

  Fly   723 ----EQK 725
                |:|
Yeast   736 RLCNEEK 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCD	NP_001245409.1	3a01203	75..715	CDD:273360	211/716 (29%)
PXA2	NP_012733.1	3a01203	24..728	CDD:273360	221/754 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I1158
eggNOG	1	0.900	-	-		E1_COG4178
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53776
OrthoFinder	1	1.000	-	-		FOG0000393
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100236
Panther	1	1.100	-	-	O	PTHR11384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.820