DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCD and abcd1

DIOPT Version :9

Sequence 1:	NP_001245409.1	Gene:	ABCD / 43772	FlyBaseID:	FBgn0039890	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_005166771.1	Gene:	abcd1 / 566367	ZFINID:	ZDB-GENE-050517-27	Length:	766	Species:	Danio rerio

Alignment Length:	738	Identity:	366/738 - (49%)
Similarity:	493/738 - (66%)	Gaps:	62/738 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVLSKYVDRIAEKCEHNGFTKHAFSYALVTSAILALT----IKVTIPYVKNVNTTSSVRTQKGK 61
            |||.||...::.:              .||..|::.|.    :|...||.            .||
Zfish     1 MSVYSKLPSQLKK--------------PLVKKAVVLLIALYGVKKLSPYF------------FGK 39

  Fly    62 TNGQLSPSTRDSSEEDFKLAEAEKLLVAQQLKKKATNNLVEPGLNKEFLKHLQMLAKIMIPQAFC 126
            ..|:.|...:.:   |...:..|.|:.|.:.:|::      |.:|:||...|..|.||:.|:.||
Zfish    40 LKGRTSKQVKGA---DPLTSNGEPLVEAARKRKRS------PAVNREFFDRLIRLLKILFPRLFC 95

  Fly   127 YETGLLSVHTFCLISRTFLSIYVAALEGALVKFIVRKDIKQFALVLLKWFGIAIPATFVNSMIRF 191
            .|.|||..|:..||||||||||||.|:|.:||.||:||.:.|.:.|.||..||||||||||.||:
Zfish    96 KELGLLGFHSLALISRTFLSIYVANLDGQIVKTIVKKDPRAFVVELTKWLLIAIPATFVNSAIRY 160

  Fly   192 LESKLSLAFRTRLVRHSYRLYFKNQNYYRVSNLDGRIENADHRLTEDISVFANSVAHLYSSLTKP 256
            ||.:|:||||||||.|:|.|||.:|.||||||:|||:.|.|..||||:.:||.|||||||:||||
Zfish   161 LEGQLTLAFRTRLVTHAYMLYFSDQTYYRVSNMDGRLANPDQSLTEDVVMFAASVAHLYSNLTKP 225

  Fly   257 CFDLMLIGLALMRSSKKMKANIITGPALSIG-VIALTAHILRIVSPKFGQLVSEEANRYGYLRHI 320
            ..|:::....|:::::...|| .|.|::..| |:||||.:||..||:||:||:|||.|.|.||::
Zfish   226 ILDVVVTCYTLIKTAESKGAN-TTWPSVIAGIVVALTAKVLRAFSPRFGKLVAEEARRKGDLRYM 289

  Fly   321 HSRIITNAEEIAFYGGHKVEMQQLRQAYNRLVNQMTTIFNQKLWFIMLEQFFMKYVWSGTGMIMV 385
            |||||.|:||||||||||:||.||:::||.|..|:..|..::||::|||||.|||:||.:|::||
Zfish   290 HSRIIANSEEIAFYGGHKIEMLQLQRSYNSLSRQINLILFKRLWYVMLEQFLMKYLWSASGLVMV 354

  Fly   386 SLPILTG---SDVGLGTVPNTAI---SESRVSERTQYLTTARNLLISAADAIERLMSSYKEIVSL 444
            ::||:|.   |......|...|:   .|..||||||..||||:||.:||||:||:|.||||:..|
Zfish   355 AVPIITATGYSKYDSEDVKQAALDMKEEDLVSERTQAFTTARSLLNAAADAVERIMVSYKEVTEL 419

  Fly   445 AGYTFRVAGMMDVFEETALGVYCKTSVMESNQSNGIIE-----FRNGKPI-AKGRIIYSDDPKNM 503
            ||||.||..|.:|||:...|||.:::.....:..|..:     .|...|: .:|::|    ....
Zfish   420 AGYTARVYEMFEVFEDVRDGVYRRSATEVKPEETGAPQNVTHGMRVEGPLQIRGQVI----DVEQ 480

  Fly   504 SISLRAVPVVTPNCDIVVPKLTLCIEPGVHLLITGPNGCGKSSLFRILSGLWPIYAGELHIPRPV 568
            .|....:|::||..|:||..|.:.::.|:||||||||||||||||||||||||:|:|.|:.|.|
Zfish   481 GIKCENLPIITPTGDVVVSSLNMQVDEGMHLLITGPNGCGKSSLFRILSGLWPVYSGVLYKPSP- 544

  Fly   569 KDVPCMFYIPQRPYMSIGSLCDQIIYPDTREDMKRKHITENELRSILKMVSLEHIAQRD-SFDVV 632
               ..|||||||||||:|:|.||:|||.:.::|:.|.||:.:|..||:.|||.:|.:|: .:|.|
Zfish   545 ---DHMFYIPQRPYMSVGTLRDQVIYPHSVQEMQEKGITDRQLEEILQTVSLRYILEREGGWDAV 606

  Fly   633 RDWKDILSGGEKQRMAIARLFYHRPRYALLDECTSAVSIDVESSIYEIAKGMGITLLTITHRPTL 697
            .||||:|||||||||.:||:|||:|:||||||||||||||||..|:|.||..||:||:|||||:|
Zfish   607 SDWKDVLSGGEKQRMGMARMFYHKPQYALLDECTSAVSIDVEGKIFEAAKDAGISLLSITHRPSL 671

  Fly   698 WKYHTHILEFDGLGNWQFRKMNS 720
            ||||:|:|:|||.|.|:|.|:::
Zfish   672 WKYHSHLLQFDGEGGWRFEKLDA 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCD	NP_001245409.1	3a01203	75..715	CDD:273360	348/653 (53%)
abcd1	XP_005166771.1	SunT	1..689	CDD:331423	364/731 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594204
Domainoid	1	1.000	324	1.000	Domainoid score	I1174
eggNOG	1	0.900	-	-		E1_COG4178
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	671	1.000	Inparanoid score	I712
OMA	1	1.010	-	-		QHG53776
OrthoDB	1	1.010	-	-		D146647at33208
OrthoFinder	1	1.000	-	-		FOG0000393
OrthoInspector	1	1.000	-	-		oto41644
orthoMCL	1	0.900	-	-		OOG6_100236
Panther	1	1.100	-	-	LDO	PTHR11384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X313
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770