DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCD and Abcd1

DIOPT Version :9

Sequence 1:	NP_001245409.1	Gene:	ABCD / 43772	FlyBaseID:	FBgn0039890	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001102291.1	Gene:	Abcd1 / 363516	RGDID:	1562128	Length:	737	Species:	Rattus norvegicus

Alignment Length:	722	Identity:	346/722 - (47%)
Similarity:	479/722 - (66%)	Gaps:	68/722 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 TSAILALT---IKVTIPYVKNVNTTSSVRTQKGKTNGQLSPSTRDSSEEDFKLAEAEKLLVAQQL 92
            |:.:||||   :....|.|:..                |:|            |...::...:..
  Rat    19 TAVVLALTAYGVHKIYPLVRQC----------------LTP------------ARGPQVPAGEST 55

  Fly    93 KKKATNNLVEPGLNKEFLKHLQMLAKIMIPQAFCYETGLLSVHTFCLISRTFLSIYVAALEGALV 157
            ::.:.....:.|:|:.||:.|.:|.:::.|...|.|||||::|:..|:||||||:|||.|:|.|.
  Rat    56 QEASGATTAKAGMNRVFLQRLLVLLRLLFPGVLCRETGLLALHSAALVSRTFLSVYVARLDGRLA 120

  Fly   158 KFIVRKDIKQFALVLLKWFGIAIPATFVNSMIRFLESKLSLAFRTRLVRHSYRLYFKNQNYYRVS 222
            :.|||||.:.|:..||:|..||:||||:||.||:||.:|:|:||:|||.|:|.|||..|.|||||
  Rat   121 RCIVRKDPRAFSWQLLQWLLIALPATFINSAIRYLEGQLALSFRSRLVAHAYGLYFSQQTYYRVS 185

  Fly   223 NLDGRIENADHRLTEDISVFANSVAHLYSSLTKPCFDLMLIGLALMRSSKKMKANIITGPALSIG 287
            |:|||:.|.|..||||:..||.|||||||:||||..|:.:....|:|:::...|......|::..
  Rat   186 NMDGRLRNPDQSLTEDMVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGL 250

  Fly   288 VIALTAHILRIVSPKFGQLVSEEANRYGYLRHIHSRIITNAEEIAFYGGHKVEMQQLRQAYNRLV 352
            |:.|||::||..|||||:||:|||.|.|.||::|||::.|:|||||||||:||:..|:.:|..|.
  Rat   251 VVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQHSYQDLA 315

  Fly   353 NQMTTIFNQKLWFIMLEQFFMKYVWSGTGMIMVSLPILTGSDVGLGTVPNTAI--------SESR 409
            :|:..|..::||::|||||.||||||.:|::||::||:|.:  |.....:.|:        .|..
  Rat   316 SQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITAT--GYAESDSEAMKKAALEMKEEEL 378

  Fly   410 VSERTQYLTTARNLLISAADAIERLMSSYKEIVSLAGYTFRVAGMMDVFEETALGVYCKTSVMES 474
            |||||:..|.|||||.:||||.||:||||||:..|||||.||..|..|||:.....:.:|..:|.
  Rat   379 VSERTEAFTIARNLLTAAADATERIMSSYKEVTELAGYTARVYEMFQVFEDVQHCRFKRTGDLEE 443

  Fly   475 NQS-------NGI-IEFRNGKPIAKGRIIYSDDPKNMSISLRAVPVVTPNCDIVVPKLTLCIEPG 531
            .|:       :|: ||   |....:|:::    .....|....:|::||..::||..|.:.:|.|
  Rat   444 AQAGPGSMVHSGVHIE---GPLKIQGQVV----DVEQGIICENIPIITPTGEVVVASLNIRVEEG 501

  Fly   532 VHLLITGPNGCGKSSLFRILSGLWPIYAGELHIPRPVKDVPCMFYIPQRPYMSIGSLCDQIIYPD 596
            :|||||||||||||||||||.||||.|:|.|:.|.|.:    |||||||||||:|||.||:||||
  Rat   502 MHLLITGPNGCGKSSLFRILGGLWPTYSGVLYKPPPQR----MFYIPQRPYMSVGSLRDQVIYPD 562

  Fly   597 TREDMKRKHITENELRSILKMVSLEHIAQRD-SFDVVRDWKDILSGGEKQRMAIARLFYHRPRYA 660
            :.|||:||..:|.:|.:||.:|.|.||.||: .::.|.||||:||||||||:.:||:|||||:||
  Rat   563 SAEDMRRKGCSEQQLEAILGIVHLRHILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYA 627

  Fly   661 LLDECTSAVSIDVESSIYEIAKGMGITLLTITHRPTLWKYHTHILEFDGLGNWQFRKMNS----- 720
            ||||||||||||||..|::.||..||:||:|||||:|||||||:|:|||.|.|:|.|::|
  Rat   628 LLDECTSAVSIDVEGKIFQAAKDAGISLLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLS 692

  Fly   721 --DEEQK 725
              :|:|:
  Rat   693 LTEEKQR 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCD	NP_001245409.1	3a01203	75..715	CDD:273360	332/656 (51%)
Abcd1	NP_001102291.1	3a01203	1..682	CDD:273360	341/703 (49%)
		Interaction with PEX19. /evidence=ECO:0000250\|UniProtKB:P33897	68..187		65/118 (55%)
		PEX19 binding site and required for peroxisomal targeting. /evidence=ECO:0000250\|UniProtKB:P33897	68..85		5/16 (31%)
		Required for homodimerization. /evidence=ECO:0000250\|UniProtKB:P33897	659..737		22/41 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352269
Domainoid	1	1.000	318	1.000	Domainoid score	I1221
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	680	1.000	Inparanoid score	I686
OMA	1	1.010	-	-		QHG53776
OrthoDB	1	1.010	-	-		D146647at33208
OrthoFinder	1	1.000	-	-		FOG0000393
OrthoInspector	1	1.000	-	-		otm45383
orthoMCL	1	0.900	-	-		OOG6_100236
Panther	1	1.100	-	-	LDO	PTHR11384
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X313
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910