DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCD and ABCD1

DIOPT Version :9

Sequence 1:	NP_001245409.1	Gene:	ABCD / 43772	FlyBaseID:	FBgn0039890	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_000024.2	Gene:	ABCD1 / 215	HGNCID:	61	Length:	745	Species:	Homo sapiens

Alignment Length:	641	Identity:	337/641 - (52%)
Similarity:	455/641 - (70%)	Gaps:	27/641 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 GLNKEFLKHLQMLAKIMIPQAFCYETGLLSVHTFCLISRTFLSIYVAALEGALVKFIVRKDIKQF 168
            |:|:.||:.|..|.:::.|:..|.|||||::|:..|:||||||:|||.|:|.|.:.|||||.:.|
Human    66 GMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRAF 130

  Fly   169 ALVLLKWFGIAIPATFVNSMIRFLESKLSLAFRTRLVRHSYRLYFKNQNYYRVSNLDGRIENADH 233
            ...||:|..||:|||||||.||:||.:|:|:||:|||.|:|||||..|.||||||:|||:.|.|.
Human   131 GWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTYYRVSNMDGRLRNPDQ 195

  Fly   234 RLTEDISVFANSVAHLYSSLTKPCFDLMLIGLALMRSSKKMKANIITGPALSIGVIALTAHILRI 298
            .||||:..||.|||||||:||||..|:.:....|:|:::...|......|::..|:.|||::||.
Human   196 SLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRA 260

  Fly   299 VSPKFGQLVSEEANRYGYLRHIHSRIITNAEEIAFYGGHKVEMQQLRQAYNRLVNQMTTIFNQKL 363
            .|||||:||:|||.|.|.||::|||::.|:|||||||||:||:..|:::|..|.:|:..|..::|
Human   261 FSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQRSYQDLASQINLILLERL 325

  Fly   364 WFIMLEQFFMKYVWSGTGMIMVSLPILTG---SDVGLGTVPNTAI---SESRVSERTQYLTTARN 422
            |::|||||.||||||.:|::||::||:|.   |:.....|...|:   .|..|||||:..|.|||
Human   326 WYVMLEQFLMKYVWSASGLLMVAVPIITATGYSESDAEAVKKAALEKKEEELVSERTEAFTIARN 390

  Fly   423 LLISAADAIERLMSSYKEIVSLAGYTFRVAGMMDVFEETALGVYCKTSVMESNQSNGIIEFRNGK 487
            ||.:|||||||:||||||:..|||||.||..|..|||:.....:.:...:|..|:......|:|.
Human   391 LLTAAADAIERIMSSYKEVTELAGYTARVHEMFQVFEDVQRCHFKRPRELEDAQAGSGTIGRSGV 455

  Fly   488 PI-----AKGRIIYSDDPKNMSISLRAVPVVTPNCDIVVPKLTLCIEPGVHLLITGPNGCGKSSL 547
            .:     .:|:::    .....|....:|:|||:.::||..|.:.:|.|:|||||||||||||||
Human   456 RVEGPLKIRGQVV----DVEQGIICENIPIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSL 516

  Fly   548 FRILSGLWPIYAGELHIPRPVKDVPCMFYIPQRPYMSIGSLCDQIIYPDTREDMKRKHITENELR 612
            ||||.||||.|.|.|:.|.|.:    |||||||||||:|||.||:||||:.|||:||..:|.:|.
Human   517 FRILGGLWPTYGGVLYKPPPQR----MFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLE 577

  Fly   613 SILKMVSLEHIAQRD-SFDVVRDWKDILSGGEKQRMAIARLFYHRPRYALLDECTSAVSIDVESS 676
            :||.:|.|.||.||: .::.:.||||:||||||||:.:||:|||||:||||||||||||||||..
Human   578 AILDVVHLHHILQREGGWEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGK 642

  Fly   677 IYEIAKGMGITLLTITHRPTLWKYHTHILEFDGLGNWQFRKMNS-------DEEQK 725
            |::.||..||.||:|||||:|||||||:|:|||.|.|:|.|::|       :|:|:
Human   643 IFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQR 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCD	NP_001245409.1	3a01203	75..715	CDD:273360	332/622 (53%)
ABCD1	NP_000024.2	3a01203	1..681	CDD:273360	332/622 (53%)
		Interaction with PEX19. /evidence=ECO:0000269\|PubMed:10777694	67..186		67/118 (57%)
		PEX19 binding site and required for peroxisomal targeting. /evidence=ECO:0000269\|PubMed:15781447	67..84		5/16 (31%)
		ABC_membrane_2	83..352	CDD:284003	147/268 (55%)
		ABCD_peroxisomal_ALDP	474..679	CDD:213190	132/208 (63%)
		Required for homodimerization. /evidence=ECO:0000269\|PubMed:17609205	658..745		22/41 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158287
Domainoid	1	1.000	320	1.000	Domainoid score	I1237
eggNOG	1	0.900	-	-		E1_COG4178
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	681	1.000	Inparanoid score	I715
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53776
OrthoDB	1	1.010	-	-		D146647at33208
OrthoFinder	1	1.000	-	-		FOG0000393
OrthoInspector	1	1.000	-	-		otm41251
orthoMCL	1	0.900	-	-		OOG6_100236
Panther	1	1.100	-	-	LDO	PTHR11384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X313
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770