Protein Alignment Abcd1 and Abcd3

DIOPT Version :10

• Sequence 1: NP_651906.1
• Gene: Abcd1 / 43772
• FlyBaseID: FBgn0039890
• Length: 730
• Species: Drosophila melanogaster
• Sequence 2: NP_033017.2
• Gene: Abcd3 / 19299
• MGIID: 1349216
• Length: 659
• Species: Mus musculus
• Alignment Length: 673
• Identity: 250/673 - (37%)
• Similarity: 383/673 - (56%)
• Gaps: 57/673 - (8%)

  Fly    60 GKTNGQLSPSTRDSSEEDFKLAEAEKLLVAQQLKKKATNNLVEPGLNKEFLKHLQMLAKIMIPQA 124
            ||.:|:  |..:::.:|..|    |:.:|                 :|.||..|..:.|||:|:.
Mouse    37 GKKSGK--PPLQNNEKEGKK----ERAVV-----------------DKVFLSRLSQILKIMVPRT 78

  Fly   125 FCYETGLLSVHTFCLISRTFLSIYVAALEGALVKF-IVRKDIKQFALVLLKWFGIAIPATFVNSM 188
            ||.|||.|.:....|:|||:..:::.. .|.|::. |:.:..|.|...|..:.......:.||:.
Mouse    79 FCKETGYLLLIAVMLVSRTYCDVWMIQ-NGTLIESGIIGRSSKDFKRYLFNFIAAMPLISLVNNF 142

  Fly   189 IRFLESKLSLAFRTRLVRHSYRLYFKNQNYYRVSNLDGRIENADHRLTEDISVFANSVAHLYSSL 253
            :::..::|.|.||.||.|:.|..|.:...||::.|||.||.|.|..||:|:..|.|||..|||:|
Mouse   143 LKYGLNELKLCFRVRLTRYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNL 207

  Fly   254 TKPCFDLMLIGLALMRSSKKMKANIITGPALSIGVIALTAHILRIVSPKFGQLVSEEANRYGYLR 318
            :||..|::|.   :.:.:..:.|.   |||..:..:.::...|..:....|::...|....|..|
Mouse   208 SKPFLDIVLY---IFKLTSAIGAQ---GPASMMAYLLVSGLFLTRLRRPIGKMTIMEQKYEGEYR 266

  Fly   319 HIHSRIITNAEEIAFYGGHKVEMQQLRQAYNRLVNQMTT--IFNQKLWFIMLEQFFMKYVWSGTG 381
            :::||:|||:||||||.|:|.|.|.:...:.:||..:..  .|...:.||  :....|||.:..|
Mouse   267 YVNSRLITNSEEIAFYNGNKREKQTIHSVFRKLVEHLHNFIFFRFSMGFI--DSIIAKYVATVVG 329

  Fly   382 MIMVSLPILTGSDVGLGTVPNTAISESRVSERTQYLTTARNLLISAADAIERLMSSYKEIVSLAG 446
            .::||.|.|     .|....:...:.|.:.|  .|..:.| :|:..:.|:.|::.:.:|:..|||
Mouse   330 YLVVSRPFL-----DLAHPRHLHSTHSELLE--DYYQSGR-MLLRMSQALGRIVLAGREMTRLAG 386

  Fly   447 YTFRVAGMMDVFEETALGVYCKTSVMESNQSNGIIEFRNGKPI--AKGRIIYSDDPKNMSISLRA 509
            :|.|:..:|.|.::...|.|.:|  |.|.|..| ||.....|:  ..|.||.:|:    .|....
Mouse   387 FTARITELMQVLKDLNHGRYERT--MVSQQEKG-IEGAQASPLVPGAGEIINTDN----IIKFDH 444

  Fly   510 VPVVTPNCDIVVPKLTLCIEPGVHLLITGPNGCGKSSLFRILSGLWPIYAGELHIPRPVKDVPCM 574
            ||:.|||.||::..|:..:..|.::||.||||||||||||:|..|||::.|.|..|...|    :
Mouse   445 VPLATPNGDILIQDLSFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGK----L 505

  Fly   575 FYIPQRPYMSIGSLCDQIIYPDTREDMKRKHITENELRSILKMVSLEHIAQRD-SFDVVRDWKDI 638
            ||:||||||::|:|.||:||||.:||.|::.|::..|:..|..|.|.||.:|: .:|.|:||.|:
Mouse   506 FYVPQRPYMTLGTLRDQVIYPDGKEDQKKRGISDQVLKEYLDNVQLGHILEREGGWDSVQDWMDV 570

  Fly   639 LSGGEKQRMAIARLFYHRPRYALLDECTSAVSIDVESSIYEIAKGMGITLLTITHRPTLWKYHTH 703
            ||||||||||:||||||:|::|:|||||||||:|||..||...:.:||||.|::||.:|||:|.:
Mouse   571 LSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVSHRKSLWKHHEY 635

  Fly   704 ILEFDGLGNWQFRKMNSDEEQKG 726
            .|..||.||::|:|:..|..:.|
Mouse   636 YLHMDGRGNYEFKKITEDTVEFG 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abcd1	NP_651906.1	3a01203	75..715	CDD:273360	242/645 (38%)
Abcd3	NP_033017.2	3a01203	1..647	CDD:273360	246/660 (37%)
		Interaction with PEX19. /evidence=ECO:0000250|UniProtKB:P28288	1..61		8/46 (17%)