DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCD and Abcd1

DIOPT Version :9

Sequence 1:NP_001245409.1 Gene:ABCD / 43772 FlyBaseID:FBgn0039890 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_031461.1 Gene:Abcd1 / 11666 MGIID:1349215 Length:736 Species:Mus musculus


Alignment Length:719 Identity:345/719 - (47%)
Similarity:475/719 - (66%) Gaps:62/719 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 TSAILALT---IKVTIPYVKNVNTTSSVRTQKGKTNGQLSPSTRDSSEEDFKLAEAEKLLVAQQL 92
            |:.:||||   :....|.|:...|.:         .|...|:...:.|.....|           
Mouse    18 TAVVLALTAYGVHKIYPLVRQCLTPA---------RGPQVPAGEPTQEASGATA----------- 62

  Fly    93 KKKATNNLVEPGLNKEFLKHLQMLAKIMIPQAFCYETGLLSVHTFCLISRTFLSIYVAALEGALV 157
                    .:.|:|:.||:.|..|.:::.|:..|.|||||::|:..|:||||||:|||.|:|.|.
Mouse    63 --------TKAGMNRVFLQRLLALLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLA 119

  Fly   158 KFIVRKDIKQFALVLLKWFGIAIPATFVNSMIRFLESKLSLAFRTRLVRHSYRLYFKNQNYYRVS 222
            :.|||||.:.|:..||:|..||:||||:||.||:||.:|:|:||:|||.|:|.|||..|.|||||
Mouse   120 RCIVRKDPRAFSWQLLQWLLIALPATFINSAIRYLEGQLALSFRSRLVAHAYGLYFSQQTYYRVS 184

  Fly   223 NLDGRIENADHRLTEDISVFANSVAHLYSSLTKPCFDLMLIGLALMRSSKKMKANIITGPALSIG 287
            |:|||:.|.|..||||:..||.|||||||:||||..|:.:....|:|:::...|......|::..
Mouse   185 NMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGL 249

  Fly   288 VIALTAHILRIVSPKFGQLVSEEANRYGYLRHIHSRIITNAEEIAFYGGHKVEMQQLRQAYNRLV 352
            |:.|||::||..|||||:||:|||.|.|.||::|||::.|:|||||||||:||:..|:.:|..|.
Mouse   250 VVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQHSYQDLA 314

  Fly   353 NQMTTIFNQKLWFIMLEQFFMKYVWSGTGMIMVSLPILTGSDVGLGTVPNTAI--------SESR 409
            :|:..|..::||::|||||.||||||.:|::||::||:|.:  |.....:.|:        .|..
Mouse   315 SQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITAT--GYAESDSEAMKKAALEMKEEEL 377

  Fly   410 VSERTQYLTTARNLLISAADAIERLMSSYKEIVSLAGYTFRVAGMMDVFEETALGVYCKTSVMES 474
            |||||:..|.|||||.:||||.||:||||||:..|||||.||..|..|||:.....:.:|..:|.
Mouse   378 VSERTEAFTIARNLLTAAADATERIMSSYKEVTELAGYTARVYEMFQVFEDVKHCRFKRTGDLEE 442

  Fly   475 NQSNGIIEFRNGKPI-----AKGRIIYSDDPKNMSISLRAVPVVTPNCDIVVPKLTLCIEPGVHL 534
            .|:...:..::|..:     .:|:::    .....|....:|::||..::||..|.:.:|.|:||
Mouse   443 AQAGPGVMVQSGVHVEGPLKIQGQVV----DVEQGIICENIPIITPTGEVVVASLNIRVEEGMHL 503

  Fly   535 LITGPNGCGKSSLFRILSGLWPIYAGELHIPRPVKDVPCMFYIPQRPYMSIGSLCDQIIYPDTRE 599
            |||||||||||||||||.||||.|:|.|:.|.|.:    |||||||||||:|||.||:||||:.|
Mouse   504 LITGPNGCGKSSLFRILGGLWPTYSGVLYKPPPQR----MFYIPQRPYMSVGSLRDQVIYPDSAE 564

  Fly   600 DMKRKHITENELRSILKMVSLEHIAQRD-SFDVVRDWKDILSGGEKQRMAIARLFYHRPRYALLD 663
            ||:||..:|.:|.:||.:|.|.||.||: .::.|.||||:||||||||:.:||:|||||:|||||
Mouse   565 DMRRKGCSEQQLEAILGIVHLRHILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYALLD 629

  Fly   664 ECTSAVSIDVESSIYEIAKGMGITLLTITHRPTLWKYHTHILEFDGLGNWQFRKMNS-------D 721
            |||||||||||..|::.||..||.||:|||||:|||||||:|:|||.|.|:|.|::|       :
Mouse   630 ECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTE 694

  Fly   722 EEQK 725
            |:|:
Mouse   695 EKQR 698

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCDNP_001245409.1 3a01203 75..715 CDD:273360 330/653 (51%)
Abcd1NP_031461.1 3a01203 1..681 CDD:273360 340/700 (49%)
Interaction with PEX19. /evidence=ECO:0000250|UniProtKB:P33897 67..186 65/118 (55%)
PEX19 binding site and required for peroxisomal targeting. /evidence=ECO:0000250|UniProtKB:P33897 67..84 5/16 (31%)
ABC_membrane_2 83..352 CDD:284003 145/268 (54%)
ABCD_peroxisomal_ALDP 474..679 CDD:213190 132/208 (63%)
Required for homodimerization. /evidence=ECO:0000250|UniProtKB:P33897 658..736 22/41 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848686
Domainoid 1 1.000 317 1.000 Domainoid score I1264
eggNOG 1 0.900 - - E1_COG4178
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 678 1.000 Inparanoid score I717
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53776
OrthoDB 1 1.010 - - D146647at33208
OrthoFinder 1 1.000 - - FOG0000393
OrthoInspector 1 1.000 - - otm43311
orthoMCL 1 0.900 - - OOG6_100236
Panther 1 1.100 - - LDO PTHR11384
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X313
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.770

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