DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCD and abcd3b

DIOPT Version :9

Sequence 1:	NP_001245409.1	Gene:	ABCD / 43772	FlyBaseID:	FBgn0039890	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001124092.1	Gene:	abcd3b / 100170781	ZFINID:	ZDB-GENE-050517-29	Length:	659	Species:	Danio rerio

Alignment Length:	731	Identity:	239/731 - (32%)
Similarity:	396/731 - (54%)	Gaps:	78/731 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVLSKYVDRIAEKCEHNGFTKHAFSYALVTSAIL--ALTIKVTIPYVKNVNTTSSVRTQKGKTN 63
            |:.:|||:               ....:.:..|:|  |..:|      :.::|.::...:||.
Zfish     1 MAAVSKYL---------------TAGNSSIAGALLFAAYVLK------QRLSTETNGYREKGS-- 42

  Fly    64 GQLSPSTRDSSEEDFKLAEAEKLLVAQQLKKKATNNLVEPGLNKEFLKHLQMLAKIMIPQAFCYE 128
               |...||:.::             ::..|.|.:|:        |.:.:..:.||::|||||.|
Zfish    43 ---SKPLRDNEKD-------------RKTDKAAVDNV--------FFRRICHILKILMPQAFCKE 83

  Fly   129 TGLLSVHTFCLISRTFLSIYVAALEGALVKFIVRKDIKQFALVLLKWFGIAIPATFVNSMIRFLE 193
            :|.|.:....|::||:..:::......:...|:.:....|...|:.:..:....:.||:.::...
Zfish    84 SGYLLLIAVMLVARTYCDVWMIHNGTMIESAIIGRSTTTFKRYLVNFITVMPFISLVNNFLKLGI 148

  Fly   194 SKLSLAFRTRLVRHSYRLYFKNQNYYRVSNLDGRIENADHRLTEDISVFANSVAHLYSSLTKPCF 258
            ::|.|.||.||..|.|..|.|...||::.|||.||.|.|..:|:|:..|.|||..|||:::||..
Zfish   149 NELKLCFRVRLTNHLYNDYLKGFTYYQIGNLDNRIANPDQLITQDVEKFCNSVVDLYSNVSKPLL 213

  Fly   259 DLMLIGLALMRSSKKMKANIITGPALSIGVIALTAHILRIVSPKFGQLVSEEANRYGYLRHIHSR 323
            |:::....|..:...:      |||..:|.:.|:..:|..:....|::...|....|..|:::||
Zfish   214 DILIYIFKLNTAIGSL------GPATLLGYLLLSGLLLTRLRRPIGKMTVTEQRYEGEYRYVNSR 272

  Fly   324 IITNAEEIAFYGGHKVEMQQLRQAYNRLVNQMTTIFNQKLWFIMLEQFFMKYVWSGTGMIMVSLP 388
            :|||:||||||.|:..|.|.:...:.:||:.::...:.:....:::....||:....|.:::|.|
Zfish   273 LITNSEEIAFYNGNLREKQTIIGTFQKLVDHLSRFIHFRFSMGVMDSIIAKYIAMAVGYLVISRP 337

  Fly   389 ILTGSDVGLGTVPNTAISESRVSERTQYLTTARNLLISAADAIERLMSSYKEIVSLAGYTFRVAG 453
            .|        .:.|.....|..:||.:....:..:|:|.|.|:.|::.:.:|:..|:|:|.|:..
Zfish   338 FL--------DISNQRHINSTYAERLEDYYQSGRMLMSLAQALGRIVLAGREMTRLSGFTARITE 394

  Fly   454 MMDVFEETALGVYCKTSVMESNQSNGIIEFRNGKPIAKGR--IIYSDDPKNMSISLRAVPVVTPN 516
            :.:|.:|...|.|.:|.|....:...:.:.    |:..||  ||.:|:    .|....:|:.|||
Zfish   395 IQEVLKELNSGKYERTMVTHRIKDTAVDKI----PLIPGRGEIIIADN----KIKFEHIPLATPN 451

  Fly   517 CDIVVPKLTLCIEPGVHLLITGPNGCGKSSLFRILSGLWPIYAGELHIPRPVKDVPCMFYIPQRP 581
            .||::..|:..:..|.::|:.||||||||||||:|..|||:..|:|..|...|    :||:||||
Zfish   452 GDILISDLSFEVSSGTNVLVCGPNGCGKSSLFRVLGELWPLCGGKLTKPERGK----LFYVPQRP 512

  Fly   582 YMSIGSLCDQIIYPDTREDMKRKHITENELRSILKMVSLEHIAQRD-SFDVVRDWKDILSGGEKQ 645
            ||::|||.||:|||||.||..:|..::..|:..|..|.|.||.:|: |::.|:||.|:|||||||
Zfish   513 YMTLGSLRDQVIYPDTLEDQMKKRTSDRVLKEYLDNVQLGHILEREGSWESVQDWMDVLSGGEKQ 577

  Fly   646 RMAIARLFYHRPRYALLDECTSAVSIDVESSIYEIAKGMGITLLTITHRPTLWKYHTHILEFDGL 710
            |||:||||||:|::|:|||||||||:|||..||...:.:||||.|::||.:|||:|.:.|..||.
Zfish   578 RMAMARLFYHKPQFAILDECTSAVSVDVEDFIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGR 642

  Fly   711 GNWQFRKMNSDEEQKG 726
            ||::|:.:..:..:.|
Zfish   643 GNYEFKPITKETVEFG 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCD	NP_001245409.1	3a01203	75..715	CDD:273360	223/642 (35%)
abcd3b	NP_001124092.1	3a01203	1..647	CDD:273360	237/718 (33%)
		ABC_membrane_2	60..339	CDD:284003	83/292 (28%)
		ABCD_peroxisomal_ALDP	440..645	CDD:213190	110/208 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4178
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53776
OrthoDB	1	1.010	-	-		D146647at33208
OrthoFinder	1	1.000	-	-		FOG0000393
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100236
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X313
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.730