DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arl4 and arc-1

DIOPT Version :9

Sequence 1:	NP_001245408.1	Gene:	Arl4 / 43771	FlyBaseID:	FBgn0039889	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	NP_496089.3	Gene:	arc-1 / 174525	WormBaseID:	WBGene00000180	Length:	539	Species:	Caenorhabditis elegans

Alignment Length:	182	Identity:	65/182 - (35%)
Similarity:	82/182 - (45%)	Gaps:	49/182 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TMVKPLV-KNGNILD-------------ALP------SQVAT-----------LH--------VV 29
            |:.|.|: :.|.|||             |.|      ||::|           ||        ||
Worm   309 TLQKALIMERGKILDRKDDLLALAESTAAEPTAVLDQSQLSTRIAFSFLNDRKLHIGDFIESRVV 373

  Fly    30 MLGLDSAGKTTALYRLKFDQYLNTV----PTIGFNCEKVQCTLGKAKGVHFLVWDVGGQEKLRPL 90
            :||||.||||:.:.|||..| ::||    ||||||.|.:.     .|......|||||..|||.|
Worm   374 LLGLDGAGKTSIVRRLKKVQ-MDTVMAPHPTIGFNIETIH-----YKNYRLNFWDVGGLPKLRHL 432

  Fly    91 WRSYTRCTDGILFVIDSVDTERMEEAKMELMRTAKCPDNQGVPVLILANKQD 142
            |:.|......|.:|||....||..||..||.|....|.....||::..|::|
Worm   433 WKHYYSNAQAIFYVIDGYAVERFSEAIKELNRVMSDPLVGTCPVIVAVNRKD 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arl4	NP_001245408.1	P-loop_NTPase	24..311	CDD:304359	54/142 (38%)
arc-1	NP_496089.3	zf-RING_5	6..54	CDD:291308
		zf-B_box	105..149	CDD:279037
		Apolipoprotein	201..>306	CDD:279749
		BBC	208..339	CDD:128778	8/29 (28%)
		Arf_Arl	371..526	CDD:206644	51/120 (43%)
		small_GTP	371..526	CDD:272973	51/120 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0070
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900