DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank and ANKRD44

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001354424.1	Gene:	ANKRD44 / 91526	HGNCID:	25259	Length:	1074	Species:	Homo sapiens

Alignment Length:	981	Identity:	283/981 - (28%)
Similarity:	430/981 - (43%)	Gaps:	135/981 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NKNGIIKQNDATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVDICCEL 92
            |.|...|::...:.:  ||..|.:..|...::.|  :::...:..|...||.||.:|.:::...|
Human   165 NINAFDKKDRRALHW--AAYMGHLDVVALLINHG--AEVTCKDKKGYTPLHAAASNGQINVVKHL 225

  Fly    93 LRRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPLYMAAQENHDNCCRT 157
            |..|::||.....||||||||...||..|:|:||.|.||||..:.||||||:.||...|...|..
Human   226 LNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLE 290

  Fly   158 LLA-NGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAKLLL 221
            ||. |||:.::.::||.:|                             ||:.|.......::.|:
Human   291 LLVNNGADVNIQSKDGKSP-----------------------------LHMTAVHGRFTRSQTLI 326

  Fly   222 QHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLL 286
            |:....|.|.|.|.||||:||.||:..:...|:.:.||......|::.|||:|........|..|
Human   327 QNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMFPLHLAALNAHSDCCRKL 391

  Fly   287 LCRGAK------------------IDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNG 333
            |..|.|                  ||...:.|.|.||.|:..|:||.||.|....|....|.|.|
Human   392 LSSGQKYSIVSLFSNEHVLSAGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 456

  Fly   334 LSALHMAAQGEHDEAAHLLLDNKAPVDEVTVDY-LTALHVAAHCGHVKVAKLLLDYKANPNARAL 397
            .:.||.||...|......|:...|.|:| |.|: .||||.|| ...:...|.:|. .|:.|:..|
Human   457 RTPLHYAAANCHFHCIETLVTTGANVNE-TDDWGRTALHYAA-ASDMDRNKTILG-NAHDNSEEL 518

  Fly   398 NGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMG---CINIVIYLLQHEASAD 459
            .....|.   :|.....:|.|:::.||.....:.|...:|.|:..|   |:.:   ||:...|..
Human   519 ERARELK---EKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLEL---LLERTNSGF 577

  Fly   460 LPTIRGET--PLHLAARANQADIIRILLRS-AKVDAIAREGQTPLHVASRLGNINIIMLLLQHGA 521
            ..:..|.|  ||||||.......:.:||:| ..:|....:|:|.|.:|:..|:...:..|:..||
Human   578 EESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINQGA 642

  Fly   522 EINAQSN-DKYSALHIAAKEGQENIVQVLLENGAENNAV---TKKGFTPLHLACKYGKQNVVQIL 582
            .|..:.| .|.:.||.:...|....:::|||......||   ..||.|||.||..||..:.|.:|
Human   643 SIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLL 707

  Fly   583 LQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCA-RNGQCAIHIACKKNYLEIAM 646
            |:..|::|.......|.||......:...|::||:...| .||. ..|:..:|.|..:.:.....
Human   708 LEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS-ILCKDSRGRTPLHYAAARGHATWLS 771

  Fly   647 QLLQHG---ADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGVISAAAKNGLTPLHVAAQEGHVL 708
            :|||..   .|.......|::|||.|...||.:.:::|||.........|..||||.|....|..
Human   772 ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGN 836

  Fly   709 VSQILLEHGA----NISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQ 769
            .:.:||  ||    .:|.|...|.||||.||...|::.::..:.:.|.:....|.|.|.|..||:
Human   837 CASLLL--GAIDSSIVSCRDDKGRTPLHAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAE 899

  Fly   770 QGHIMIINLLLRH-KANPNALTKDGNTALHIASNLGY----VTVMESLKIVTSTSVINSNIGAIE 829
            .|....:::|:.. :|:.....||.||.||:|.:.|:    :.:::.::   ..|:||....|::
Human   900 NGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQ---DESLINEKNNALQ 961

  Fly   830 --------EKLKVMTPELMQETLLSDSDDESCDDLLDHN-HYKYMATDDLKANYGQDQKNFDTTN 885
                    ..|||:..||:.:        .:|...:|.| |...:|....|
Human   962 TPLHVAARNGLKVVVEELLAK--------GACVLAVDENGHTPALACAPNK-------------- 1004

  Fly   886 TDHDLTDVSVLNKKEILP----NEMSCIELTEIGHKPDNVVIARSQV-HLGFLVSFLVDARGGSM 945
               |:.|...|....::|    :.|..:....:  |.||  ::|:.: :||.:|| |.....||.
Human  1005 ---DVADCLALILATMMPFSPSSTMMAVNFVCL--KKDN--LSRTTLSNLGSMVS-LCSNNVGSE 1061

  Fly   946 RGYRHN 951
            .||..|
Human  1062 DGYNEN 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125	48/125 (38%)
		ANK repeat	72..103	CDD:293786	11/30 (37%)
		Ank_2	77..167	CDD:289560	44/90 (49%)
		ANK repeat	105..136	CDD:293786	19/30 (63%)
		ANK repeat	138..169	CDD:293786	15/31 (48%)
		ANK	204..320	CDD:238125	42/133 (32%)
		ANK repeat	204..231	CDD:293786	6/26 (23%)
		Ank_2	205..295	CDD:289560	31/107 (29%)
		ANK repeat	233..264	CDD:293786	12/30 (40%)
		ANK repeat	266..295	CDD:293786	11/46 (24%)
		ANK	294..419	CDD:238125	41/125 (33%)
		ANK repeat	299..330	CDD:293786	12/30 (40%)
		Ank_4	300..353	CDD:290365	20/52 (38%)
		ANK repeat	332..363	CDD:293786	10/30 (33%)
		Ank_2	337..428	CDD:289560	28/91 (31%)
		ANK	360..485	CDD:238125	36/130 (28%)
		ANK repeat	365..395	CDD:293786	11/30 (37%)
		ANK repeat	398..427	CDD:293786	6/28 (21%)
		ANK repeat	431..462	CDD:293786	8/33 (24%)
		Ank_2	436..526	CDD:289560	28/95 (29%)
		ANK repeat	464..494	CDD:293786	12/32 (38%)
		ANK	491..616	CDD:238125	38/128 (30%)
		ANK repeat	496..527	CDD:293786	9/30 (30%)
		Ank_2	501..592	CDD:289560	31/94 (33%)
		ANK repeat	529..560	CDD:293786	9/33 (27%)
		ANK	557..682	CDD:238125	39/131 (30%)
		ANK repeat	562..590	CDD:293786	13/27 (48%)
		Ank_5	582..636	CDD:290568	15/54 (28%)
		ANK repeat	595..625	CDD:293786	7/29 (24%)
		ANK repeat	628..657	CDD:293786	7/31 (23%)
		Ank_2	633..723	CDD:289560	28/96 (29%)
		ANK repeat	661..691	CDD:293786	10/29 (34%)
		ANK	692..812	CDD:238125	39/128 (30%)
		ANK repeat	693..724	CDD:293786	12/34 (35%)
		Ank_2	698..788	CDD:289560	28/94 (30%)
		ANK repeat	726..755	CDD:293786	9/28 (32%)
		ANK repeat	759..788	CDD:293786	8/29 (28%)
		ZU5	930..1034	CDD:128514	10/22 (45%)
		Death_ank	1439..1521	CDD:260029
ANKRD44	NP_001354424.1	ANK 1	7..36
		ANK 2	40..69
		ANK 3	73..102
		ANK 4	106..135
		ANK 5	139..168		1/2 (50%)
		ANK 6	172..201		5/32 (16%)
		ANK 7	205..234		10/28 (36%)
		ANK 8	238..267		18/28 (64%)
		ANK 9	271..301		15/29 (52%)
		ANK 10	305..334		8/57 (14%)
		ANK 11	338..367		12/28 (43%)
		ANK 13	422..451		12/28 (43%)
		ANK 14	455..484		9/28 (32%)
		ANK 15	488..516		10/29 (34%)
		ANK 16	549..579		8/32 (25%)
		ANK 17	584..613		10/28 (36%)
		ANK 18	617..646		9/28 (32%)
		ANK 19	651..680		7/28 (25%)
		ANK 20	687..716		13/28 (46%)
		ANK 21	720..749		7/29 (24%)
		ANK 22	753..782		6/28 (21%)
		ANK 23	789..818		10/28 (36%)
		ANK 24	821..850		11/30 (37%)
		ANK 25	856..885		9/28 (32%)
		ANK 26	889..919		8/29 (28%)
		ANK 27	923..952		7/31 (23%)
		ANK 28	959..988		7/36 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710