DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank and AVO2

DIOPT Version :9

Sequence 1:NP_001162819.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_013784.1 Gene:AVO2 / 855090 SGDID:S000004672 Length:426 Species:Saccharomyces cerevisiae


Alignment Length:475 Identity:102/475 - (21%)
Similarity:178/475 - (37%) Gaps:139/475 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   495 REGQTPLHVASRLGNINIIMLLLQHGAEI--NAQSNDKYSALHIAAKEGQENIVQVLLENGAENN 557
            :|....|..|...||:.|:..||:...::  |..|.:.:|:||.|:..|:..|...|::.|.:.:
Yeast     3 KEPSVRLREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKH 67

  Fly   558 AVTK--KGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGS 620
            .:.|  ||.|.:|||...|.:..:.:|||                      ..|..:        
Yeast    68 ELIKTFKGNTCVHLALMKGHEQTLHLLLQ----------------------QFPRFI-------- 102

  Fly   621 SPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYG 685
              |....||:..|||||..:|.:....|:..|||:.::..:|.:|||:..:.|::..:::||..|
Yeast   103 --NHRGENGRAPIHIACMNDYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEG 165

  Fly   686 VIS----AAAKNGLTPLHVAA--QEGHVLVSQILLE-------HGANISERTRNGYTPLHMAAHY 737
            .:|    ...|....|:.||.  :.|:: .|::|.|       .||  .::..:..||:..|   
Yeast   166 EVSLDDNVRDKGNWKPIDVAQTFEVGNI-YSKVLKEVKKKGPPLGA--GKKPSSFRTPILNA--- 224

  Fly   738 GHLDLVKFFIENDADIEMSSNIGY------TPL---------HQAAQQG---HIMIINLLLRHKA 784
                  |...|:.....:|.|..|      :||         |..:..|   ...|.|.:.    
Yeast   225 ------KATFEDGPSPVLSMNSPYSLYSNNSPLPVLPRRISTHTTSGNGGNRRSSITNPVF---- 279

  Fly   785 NP-------NALTKDGNTALHIASNLGYV-----------TVMESLKIVTSTSVINSNIGAIEEK 831
            ||       ::.:...|::..:..|...|           .|.||::...:.:..::||..|.  
Yeast   280 NPRKPTLSTDSFSSSSNSSSRLRVNSINVKTPVGVSPKKELVSESVRHSATPTSPHNNIALIN-- 342

  Fly   832 LKVMTPELMQETLLSDSDDESCD-------------------DLLDHNHYKYMATDDLKANYGQD 877
             :.:.|....:.:..||...:.:                   |..|.|..||    .:|.|.|:.
Yeast   343 -RYLLPNKSNDNVRGDSQTATINDDGGGGNGGDATIGMGLRKDPDDENENKY----KIKVNNGEP 402

  Fly   878 QKNFDTTNTDHDLTDVSVLN 897
            ::.            ||:||
Yeast   403 RRR------------VSLLN 410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_001162819.1 ANK 67..192 CDD:238125
ANK repeat 72..103 CDD:293786
Ank_2 77..167 CDD:289560
ANK repeat 105..136 CDD:293786
ANK repeat 138..169 CDD:293786
ANK 204..320 CDD:238125
ANK repeat 204..231 CDD:293786
Ank_2 205..295 CDD:289560
ANK repeat 233..264 CDD:293786
ANK repeat 266..295 CDD:293786
ANK 294..419 CDD:238125
ANK repeat 299..330 CDD:293786
Ank_4 300..353 CDD:290365
ANK repeat 332..363 CDD:293786
Ank_2 337..428 CDD:289560
ANK 360..485 CDD:238125
ANK repeat 365..395 CDD:293786
ANK repeat 398..427 CDD:293786
ANK repeat 431..462 CDD:293786
Ank_2 436..526 CDD:289560 9/32 (28%)
ANK repeat 464..494 CDD:293786
ANK 491..616 CDD:238125 30/124 (24%)
ANK repeat 496..527 CDD:293786 9/32 (28%)
Ank_2 501..592 CDD:289560 28/94 (30%)
ANK repeat 529..560 CDD:293786 8/30 (27%)
ANK 557..682 CDD:238125 30/126 (24%)
ANK repeat 562..590 CDD:293786 10/27 (37%)
Ank_5 582..636 CDD:290568 9/53 (17%)
ANK repeat 595..625 CDD:293786 2/29 (7%)
ANK repeat 628..657 CDD:293786 12/28 (43%)
Ank_2 633..723 CDD:289560 29/102 (28%)
ANK repeat 661..691 CDD:293786 9/33 (27%)
ANK 692..812 CDD:238125 31/164 (19%)
ANK repeat 693..724 CDD:293786 9/39 (23%)
Ank_2 698..788 CDD:289560 24/123 (20%)
ANK repeat 726..755 CDD:293786 5/28 (18%)
ANK repeat 759..788 CDD:293786 9/53 (17%)
ZU5 930..1034 CDD:128514
Death_ank 1439..1521 CDD:260029
AVO2NP_013784.1 Ank_4 9..60 CDD:372654 15/50 (30%)
ANK repeat 9..37 CDD:293786 8/27 (30%)
ANKYR 37..>185 CDD:223738 45/179 (25%)
ANK repeat 39..72 CDD:293786 8/32 (25%)
ANK repeat 75..106 CDD:293786 11/62 (18%)
ANK repeat 108..139 CDD:293786 12/30 (40%)
ANK repeat 141..165 CDD:293786 7/23 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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