DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank and TNKS2

DIOPT Version :9

Sequence 1:NP_001162819.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:XP_005270242.2 Gene:TNKS2 / 80351 HGNCID:15677 Length:1190 Species:Homo sapiens


Alignment Length:1189 Identity:311/1189 - (26%)
Similarity:483/1189 - (40%) Gaps:243/1189 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 ATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNA--LHLAAKD----------------- 83
            |......|.|:||:::|...:   ....:||.:..|..:  ||.||.:                 
Human    24 AARELFEACRNGDVERVKRLV---TPEKVNSRDTAGRKSTPLHFAAGNRGQRPLASLQTPPAQPG 85

  Fly    84 ----GYVDICCELLRRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPLY 144
                |..|:...||:.|..:......|...||.|...|..:|:|.|:.:.|:.|.:....:|||:
Human    86 PTGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLH 150

  Fly   145 MAAQENHDNCCRTLLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAA 209
            .||.:...:.|..||.:||.|::...||.|.|.:|     |.....:|..:.: |..|  |..|.
Human   151 EAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA-----DPSAKAVLTGEYK-KDEL--LESAR 207

  Fly   210 KKNDVNAAKLLLQHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVA 274
            ..|:.....||...:.|.........||||:||.|..|.|..|||.:.|||:...|.::.|||.|
Human   208 SGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNA 272

  Fly   275 CKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNA-PILTKTKNGLSALH 338
            |.:|...:..||:..||.::|......||||.|:....|||...||...| |.|....| .||:.
Human   273 CSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN-KSAID 336

  Fly   339 MAAQGE------HDEAAHLLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARAL 397
            :|...:      ::...|.||......|...:....:|.             ::::| :|.... 
Human   337 LAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLE-------------MVNFK-HPQTHE- 386

  Fly   398 NGFTPLHIACKK---NRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASAD 459
               |.||.|...   .|.::.|||::.||||...|:..||||||||.....::|..:::||    
Human   387 ---TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHE---- 444

  Fly   460 LPTIRGETPLHLAARANQADIIRILLRSAKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEIN 524
                                        |||:|:...|||.||.|:..|::....|||.:|.:.|
Human   445 ----------------------------AKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPN 481

  Fly   525 AQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTKKGF------------------------- 564
            ..|...::||.:    |.|| ||.||::...|....|:..                         
Human   482 IISLQGFTALQM----GNEN-VQQLLQDLVHNLPNCKRTLLSDEMPSIKLGSIFQIEKLCTVQSV 541

  Fly   565 ----------TPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNG 619
                      ||||.|..|.:.:||:.|||:||.:..:.|..:.|||.|..|.:..:.|||:|:|
Human   542 NCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHG 606

  Fly   620 SSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEY 684
            :..|:........:|.|..|...||...|||||||....::.|.:||.| .:.|:.|:..||...
Human   607 AVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLLRGD 670

  Fly   685 GVISAAAKNGL-----------------------TPLHVAAQEGHVLVSQILLEHGANISERTRN 726
            ..:..|||.|.                       ||||:||...::.|::.||:|||:::.:.:.
Human   671 AALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 735

  Fly   727 GYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTK 791
            |..|||.||.|||:|:....|:.:|.:..:....:||||:|||:|...:..|||.|.|:|....:
Human   736 GLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQ 800

  Fly   792 DGNTALHIASN------LGYVTVMESLKIVTSTSVINSNIGAIEEKLKVMTPELMQETLLSDSDD 850
            :|.|.|.:.|.      |.......:|.......|:|.          |.:|....:.|.|....
Human   801 EGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNG----------VRSPGATADALSSGPSS 855

  Fly   851 ESCDDLLDHNHYKYMATDDLKANYGQDQKNFDTTNTDHDLTDVSVLNKKEILPNEMSCIELTE-- 913
            .|......       :.|:|..::.:......::.|:    ..|.|.|||:...:.|..:...  
Human   856 PSSLSAAS-------SLDNLSGSFSELSSVVSSSGTE----GASSLEKKEVPGVDFSITQFVRNL 909

  Fly   914 -IGHKPDNVVIARSQVHLGFLVSF---LVDARGGSMRGYRHNGVRIIVPPKACAEPTRITCRYVK 974
             :.|..|  :..|.|:.|..||..   .:...|.:..|:||..::.:.             |.:.
Human   910 GLEHLMD--IFEREQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVE-------------RLIS 959

  Fly   975 PQRVVNPPPLMEGEALVSRILEMSPVDGMFLSPITLEVPHYGTLRK-----------NEREII-I 1027
            .|:.:||...:......:.::::||.|..|.|   :|.....|:|:           |...|: |
Human   960 GQQGLNPYLTLNTSGSGTILIDLSPDDKEFQS---VEEEMQSTVREHRDGGHAGGIFNRYNILKI 1021

  Fly  1028 LRSDNGESWREH-NLYKDIIGEDINQTEE---FHSDRIVR-IVTQNVPHFFAVV----------- 1076
            .:..|.:.|..: :..|::..|:.|...|   ||....|. |:.:......|.:           
Human  1022 QKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFA 1086

  Fly  1077 ---SRVRQEVHVIGPDGGT 1092
               |:..|.|:.||  |||
Human  1087 ENSSKSNQYVYGIG--GGT 1103

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_001162819.1 ANK 67..192 CDD:238125 39/147 (27%)
ANK repeat 72..103 CDD:293786 10/53 (19%)
Ank_2 77..167 CDD:289560 30/110 (27%)
ANK repeat 105..136 CDD:293786 10/30 (33%)
ANK repeat 138..169 CDD:293786 11/30 (37%)
ANK 204..320 CDD:238125 41/115 (36%)
ANK repeat 204..231 CDD:293786 6/26 (23%)
Ank_2 205..295 CDD:289560 32/89 (36%)
ANK repeat 233..264 CDD:293786 15/30 (50%)
ANK repeat 266..295 CDD:293786 10/28 (36%)
ANK 294..419 CDD:238125 32/134 (24%)
ANK repeat 299..330 CDD:293786 13/31 (42%)
Ank_4 300..353 CDD:290365 18/59 (31%)
ANK repeat 332..363 CDD:293786 8/36 (22%)
Ank_2 337..428 CDD:289560 20/99 (20%)
ANK 360..485 CDD:238125 28/127 (22%)
ANK repeat 365..395 CDD:293786 3/29 (10%)
ANK repeat 398..427 CDD:293786 12/31 (39%)
ANK repeat 431..462 CDD:293786 11/30 (37%)
Ank_2 436..526 CDD:289560 24/89 (27%)
ANK repeat 464..494 CDD:293786 4/29 (14%)
ANK 491..616 CDD:238125 46/159 (29%)
ANK repeat 496..527 CDD:293786 12/30 (40%)
Ank_2 501..592 CDD:289560 34/125 (27%)
ANK repeat 529..560 CDD:293786 10/30 (33%)
ANK 557..682 CDD:238125 45/159 (28%)
ANK repeat 562..590 CDD:293786 13/62 (21%)
Ank_5 582..636 CDD:290568 18/53 (34%)
ANK repeat 595..625 CDD:293786 11/29 (38%)
ANK repeat 628..657 CDD:293786 12/28 (43%)
Ank_2 633..723 CDD:289560 36/112 (32%)
ANK repeat 661..691 CDD:293786 8/29 (28%)
ANK 692..812 CDD:238125 45/148 (30%)
ANK repeat 693..724 CDD:293786 13/53 (25%)
Ank_2 698..788 CDD:289560 36/89 (40%)
ANK repeat 726..755 CDD:293786 12/28 (43%)
ANK repeat 759..788 CDD:293786 14/28 (50%)
ZU5 930..1034 CDD:128514 23/118 (19%)
Death_ank 1439..1521 CDD:260029
TNKS2XP_005270242.2 Ank_2 28..142 CDD:372319 27/116 (23%)
ANK repeat 60..109 CDD:293786 9/48 (19%)
PHA02876 <94..>479 CDD:165207 129/443 (29%)
ANK repeat 111..142 CDD:293786 10/30 (33%)
ANK repeat 144..175 CDD:293786 11/30 (37%)
ANK repeat 234..262 CDD:293786 15/27 (56%)
ANK repeat 264..295 CDD:293786 11/30 (37%)
ANK repeat 297..328 CDD:293786 13/30 (43%)
ANK repeat 386..418 CDD:293786 12/35 (34%)
ANK repeat 420..451 CDD:293786 15/62 (24%)
ANK repeat 453..482 CDD:293786 11/28 (39%)
PHA03095 540..>826 CDD:222980 92/286 (32%)
ANK repeat 552..580 CDD:293786 13/27 (48%)
ANK repeat 582..613 CDD:293786 11/30 (37%)
ANK repeat 615..646 CDD:293786 12/30 (40%)
ANK repeat 668..698 CDD:293786 4/29 (14%)
ANK repeat 705..733 CDD:293786 12/27 (44%)
ANK repeat 735..766 CDD:293786 12/30 (40%)
ANK repeat 768..799 CDD:293786 14/30 (47%)
SAM_tankyrase1,2 895..960 CDD:188923 13/79 (16%)
tankyrase_like 962..1184 CDD:238718 32/147 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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