DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank and ANKRD53

DIOPT Version :9

Sequence 1:NP_001162819.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_001108588.1 Gene:ANKRD53 / 79998 HGNCID:25691 Length:530 Species:Homo sapiens


Alignment Length:446 Identity:101/446 - (22%)
Similarity:161/446 - (36%) Gaps:140/446 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   662 GFSPLHLAAQGGNVDMVQLLL-EYGV-ISAAAKNGLTPLHVAAQEGHVLVS----QILLEHGANI 720
            ||:.:|.|||.|.:..:|:|: ||.. :.....|..||||:.....:..|:    ..|||.||::
Human   140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADL 204

  Fly   721 SERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKAN 785
            :.:|.||.||||:||..|.||.||..:::.|::.....:||.|:....          :..|:|.
Human   205 NAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCK----------IWNHRAC 259

  Fly   786 PNALTKDGNTALHIASNLGYVTVMESLKIVTSTSVINSNIGAIE--EKLKVMTPELMQETLLSDS 848
            ...| ||   |:.......:...|..:|:..|...:..:...||  ::.|::....:::.|    
Human   260 ARFL-KD---AMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEYQKEHKILREAAIRKWL---- 316

  Fly   849 DDESCDDLLDHNHYKYMATDDLKANYGQ----------DQKNFDTTNTDHDLTDVSVLNKKEILP 903
                        |.|......|.:|..|          :|:....:.:.|...|.          
Human   317 ------------HGKLHPGHSLVSNTKQARATALSKTPEQRESQRSRSFHPSVDA---------- 359

  Fly   904 NEMSCI-ELTEIGH---------------------KPDNVVIARSQ-VHLGF---------LVSF 936
             .:.|| :.||:..                     :|....|:.|| :.||.         ..||
Human   360 -RLQCIPQPTEMPKPIYRKPTVKRPTMWNVSNNPARPPTTQISHSQGIRLGVHPDPTPEHDFSSF 423

  Fly   937 LVDARGGSMRGYRHNGVRIIVPPKACAEPTRITCRYVKPQRVVNPPPLMEGEALVSRIL------ 995
            |      .:|...|.|.|:                :......|.|.|.:..|.|: |:|      
Human   424 L------EVRPDGHGGARL----------------HTVDGHWVAPVPRLPFEVLL-RMLYPRVWP 465

  Fly   996 -EMSPVDGMFLSPITL-EVP---HYG-------TLRKNERE------IIILRSDNG 1033
             .|....|.:  ||:: |||   |.|       ||..|.|:      :..:||..|
Human   466 YRMKVPQGFY--PISMREVPRKRHLGDNTFWTDTLAMNLRDTFDEAFLAAVRSHQG 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_001162819.1 ANK 67..192 CDD:238125
ANK repeat 72..103 CDD:293786
Ank_2 77..167 CDD:289560
ANK repeat 105..136 CDD:293786
ANK repeat 138..169 CDD:293786
ANK 204..320 CDD:238125
ANK repeat 204..231 CDD:293786
Ank_2 205..295 CDD:289560
ANK repeat 233..264 CDD:293786
ANK repeat 266..295 CDD:293786
ANK 294..419 CDD:238125
ANK repeat 299..330 CDD:293786
Ank_4 300..353 CDD:290365
ANK repeat 332..363 CDD:293786
Ank_2 337..428 CDD:289560
ANK 360..485 CDD:238125
ANK repeat 365..395 CDD:293786
ANK repeat 398..427 CDD:293786
ANK repeat 431..462 CDD:293786
Ank_2 436..526 CDD:289560
ANK repeat 464..494 CDD:293786
ANK 491..616 CDD:238125
ANK repeat 496..527 CDD:293786
Ank_2 501..592 CDD:289560
ANK repeat 529..560 CDD:293786
ANK 557..682 CDD:238125 8/19 (42%)
ANK repeat 562..590 CDD:293786
Ank_5 582..636 CDD:290568
ANK repeat 595..625 CDD:293786
ANK repeat 628..657 CDD:293786
Ank_2 633..723 CDD:289560 22/66 (33%)
ANK repeat 661..691 CDD:293786 11/30 (37%)
ANK 692..812 CDD:238125 36/123 (29%)
ANK repeat 693..724 CDD:293786 11/34 (32%)
Ank_2 698..788 CDD:289560 28/93 (30%)
ANK repeat 726..755 CDD:293786 14/28 (50%)
ANK repeat 759..788 CDD:293786 5/28 (18%)
ZU5 930..1034 CDD:128514 32/137 (23%)
Death_ank 1439..1521 CDD:260029
ANKRD53NP_001108588.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..99
Ank_4 112..160 CDD:290365 8/19 (42%)
ANK 136..263 CDD:238125 42/132 (32%)
ANK 1 139..169 11/28 (39%)
ANK repeat 140..171 CDD:293786 11/30 (37%)
Ank_2 144..241 CDD:289560 35/96 (36%)
ANK repeat 173..208 CDD:293786 11/34 (32%)
ANK 2 173..206 11/32 (34%)
ANK repeat 210..241 CDD:293786 14/30 (47%)
ANK 3 210..239 14/28 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..360 6/47 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 383..402 2/18 (11%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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