DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ank and Tnks2

DIOPT Version :9

Sequence 1:NP_001162819.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_001157107.1 Gene:Tnks2 / 74493 MGIID:1921743 Length:1166 Species:Mus musculus


Alignment Length:1157 Identity:314/1157 - (27%)
Similarity:496/1157 - (42%) Gaps:166/1157 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 CAINGMALDNKNGIIKQNDATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNA--LHLAA 81
            ||..|.|..:......:..|...| .|.|:||:::|...:   ....:||.:..|..:  ||.||
Mouse     6 CAGGGAACASAGAEAVEPSARELF-EACRNGDVERVKRLV---TPEKVNSRDTAGRKSTPLHFAA 66

  Fly    82 KDGYVDICCELLRRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPLYMA 146
            ..|..|:...||:.|..:......|...||.|...|..:|:|.|:.:.|:.|.:....:|||:.|
Mouse    67 GFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLQHGADPNARDNWNYTPLHEA 131

  Fly   147 AQENHDNCCRTLLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKK 211
            |.:...:.|..||.:||.|::...||.|.|.:|     |.....:|..|.: |..|  |..|...
Mouse   132 AIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA-----DPSAKAVLTGDYK-KDEL--LESARSG 188

  Fly   212 NDVNAAKLLLQHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACK 276
            |:.....||...:.|.........||||:||.|..|.|..|||::.|||:...|.::.|||.||.
Mouse   189 NEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLHHGADVHAKDKGDLVPLHNACS 253

  Fly   277 WGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNA-PILTKTKNGLSALHMA 340
            :|...:..||:..||.::|......||||.|:....:||...||...| |.|....| .||:.:|
Mouse   254 YGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRIEVCSLLLSYGADPTLLNCHN-KSAIDLA 317

  Fly   341 AQGE------HDEAAHLLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNG 399
            ...:      ::...|.||......|...:....:|.             ::::| :|....   
Mouse   318 PTAQLKERLSYEFKGHSLLQAAREADVTRIKKHLSLE-------------MVNFK-HPQTHE--- 365

  Fly   400 FTPLHIACKK---NRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLP 461
             |.||.|...   .|.::.|||::.|||....|:..||||||||.....::|..:::|||..:..
Mouse   366 -TALHCAAASPYPKRKQICELLLRKGANTNEKTKEFLTPLHVASENAHNDVVEVVVKHEAKVNAL 429

  Fly   462 TIRGETPLHLAARANQADIIRILLR-SAKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINA 525
            ...|:|.||.||........|:||. ....:.|:.:|.|.|    ::||.| :..|||.||.:..
Mouse   430 DSLGQTSLHRAAHCGHLQTCRLLLSYGCDPNIISLQGFTAL----QMGNEN-VQQLLQEGASLGH 489

  Fly   526 QSNDKYSALHIAAKEGQENIVQVLLENGAEN-NAVTKKGFTPLHLACKYGKQNVVQILLQNGASI 589
            ...|:  .|..|||.|....|:.|....:.| ..:..:..||||.|..|.:.:||:.|||:||.:
Mouse   490 SEADR--QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552

  Fly   590 DFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGAD 654
            ..:.|..:.|||.|..|.:..:.|||:|:|:..|:........:|.|..|...||...|||||||
Mouse   553 HAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGAD 617

  Fly   655 VNIISKSGFSPLHLAAQGGNVDMVQLLLEYGVISAAAKNGL-----------------------T 696
            ....::.|.:||.| .:.|:.|:..||.....:..|||.|.                       |
Mouse   618 PTKKNRDGNTPLDL-VKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHST 681

  Fly   697 PLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGY 761
            |||:||...::.|::.||:|||:::.:.:.|..|||.||.|||:|:....|:.:|.:..:....:
Mouse   682 PLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAF 746

  Fly   762 TPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASN------LGYVTVMESLKIVTSTSV 820
            ||||:|||:|...:..|||.|.|:|....::|.|.|.:.|.      |.......:|.......|
Mouse   747 TPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPTCYKPQV 811

  Fly   821 INS--NIGAIEEKLK--VMTPELMQETLLSDSDDESCDDLLDHNHYKYMATDDLKANYGQDQKNF 881
            ::.  ..||..:.|.  ..:|..:......|:...|..:|     ...:::...:...|..:|  
Mouse   812 LSGVRGPGATADALSSGPSSPSSLSAASSLDNLSGSFSEL-----SAVVSSSAAEGATGLQRK-- 869

  Fly   882 DTTNTDHDLT----DVSVLNKKEILPNEMSCIE-LTEIGHKPDNVVIARSQVHLGFLVSFLVDAR 941
            :.:..|..:|    ::.:.:..:|...|...:: |.|:|||....:                   
Mouse   870 EDSGIDFSITQFIRNLGLEHLMDIFEREQITLDVLVEMGHKELKEI------------------- 915

  Fly   942 GGSMRGYRHNGVRIIVPPKACAEPTRITCRYVKPQRVVNPPPLMEGEALVSRILEMSPVDGMFLS 1006
            |.:..|:||..::.:.             |.:..|:.:||...:......:.::::||.|..|.|
Mouse   916 GINAYGHRHKLIKGVE-------------RLISGQQGLNPYLTLNNSGSGTILIDLSPDDKEFQS 967

  Fly  1007 PITLEVPHYGTLRK-----------NEREII-ILRSDNGESWREH-NLYKDIIGEDINQTEE--- 1055
               :|.....|:|:           |...|: |.:..|.:.|..: :..|::..|:.|...|   
Mouse   968 ---VEEEMQSTVREHRDGGHAGGVFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERML 1029

  Fly  1056 FHSDRIVR-IVTQNVPHFFAVV--------------SRVRQEVHVIGPDGGT 1092
            ||....|. |:.:......|.:              |:..|.|:.||  |||
Mouse  1030 FHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIG--GGT 1079

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_001162819.1 ANK 67..192 CDD:238125 39/126 (31%)
ANK repeat 72..103 CDD:293786 10/32 (31%)
Ank_2 77..167 CDD:289560 30/89 (34%)
ANK repeat 105..136 CDD:293786 10/30 (33%)
ANK repeat 138..169 CDD:293786 11/30 (37%)
ANK 204..320 CDD:238125 40/115 (35%)
ANK repeat 204..231 CDD:293786 6/26 (23%)
Ank_2 205..295 CDD:289560 32/89 (36%)
ANK repeat 233..264 CDD:293786 15/30 (50%)
ANK repeat 266..295 CDD:293786 10/28 (36%)
ANK 294..419 CDD:238125 31/134 (23%)
ANK repeat 299..330 CDD:293786 12/31 (39%)
Ank_4 300..353 CDD:290365 17/59 (29%)
ANK repeat 332..363 CDD:293786 8/36 (22%)
Ank_2 337..428 CDD:289560 19/99 (19%)
ANK 360..485 CDD:238125 35/127 (28%)
ANK repeat 365..395 CDD:293786 3/29 (10%)
ANK repeat 398..427 CDD:293786 11/31 (35%)
ANK repeat 431..462 CDD:293786 12/30 (40%)
Ank_2 436..526 CDD:289560 30/90 (33%)
ANK repeat 464..494 CDD:293786 9/30 (30%)
ANK 491..616 CDD:238125 42/125 (34%)
ANK repeat 496..527 CDD:293786 11/30 (37%)
Ank_2 501..592 CDD:289560 31/91 (34%)
ANK repeat 529..560 CDD:293786 9/31 (29%)
ANK 557..682 CDD:238125 44/124 (35%)
ANK repeat 562..590 CDD:293786 13/27 (48%)
Ank_5 582..636 CDD:290568 18/53 (34%)
ANK repeat 595..625 CDD:293786 11/29 (38%)
ANK repeat 628..657 CDD:293786 12/28 (43%)
Ank_2 633..723 CDD:289560 36/112 (32%)
ANK repeat 661..691 CDD:293786 8/29 (28%)
ANK 692..812 CDD:238125 45/148 (30%)
ANK repeat 693..724 CDD:293786 13/53 (25%)
Ank_2 698..788 CDD:289560 36/89 (40%)
ANK repeat 726..755 CDD:293786 12/28 (43%)
ANK repeat 759..788 CDD:293786 14/28 (50%)
ZU5 930..1034 CDD:128514 20/115 (17%)
Death_ank 1439..1521 CDD:260029
Tnks2NP_001157107.1 ANK 1 23..52 8/32 (25%)
Ank_4 28..78 CDD:290365 15/53 (28%)
ANK 50..164 CDD:238125 37/113 (33%)
ANK 2 57..86 9/28 (32%)
ANK repeat 60..88 CDD:293786 9/27 (33%)
Ank_2 62..154 CDD:289560 30/91 (33%)
ANK repeat 90..121 CDD:293786 10/30 (33%)
ANK 3 90..119 9/28 (32%)
ANK repeat 123..154 CDD:293786 11/30 (37%)
ANK 4 123..152 11/28 (39%)
ANK 203..317 CDD:238125 43/114 (38%)
ANK 5 210..239 15/28 (54%)
ANK repeat 213..241 CDD:293786 15/27 (56%)
Ank_2 215..307 CDD:289560 37/91 (41%)
ANK repeat 243..274 CDD:293786 11/30 (37%)
ANK 6 243..272 10/28 (36%)
ANK repeat 276..307 CDD:293786 12/30 (40%)
ANK 7 276..305 11/28 (39%)
ANK 8 363..395 11/35 (31%)
ANK repeat 365..397 CDD:293786 11/35 (31%)
Ank_2 368..461 CDD:289560 32/92 (35%)
ANK 394..579 CDD:238125 64/191 (34%)
ANK repeat 399..430 CDD:293786 12/30 (40%)
ANK 9 399..428 12/28 (43%)
ANK 10 432..461 9/28 (32%)
ANK repeat 433..521 CDD:293786 30/94 (32%)
Ank_2 437..556 CDD:289560 41/125 (33%)
ANK 11 463..489 11/30 (37%)
ANK 518..643 CDD:238125 44/125 (35%)
ANK 12 525..554 13/28 (46%)
ANK repeat 528..556 CDD:293786 13/27 (48%)
Ank_2 530..622 CDD:289560 35/91 (38%)
HIF1AN-binding. /evidence=ECO:0000250|UniProtKB:Q9H2K2 545..553 5/7 (71%)
ANK repeat 558..589 CDD:293786 11/30 (37%)
ANK 13 558..587 10/28 (36%)
ANK repeat 591..622 CDD:293786 12/30 (40%)
ANK 14 591..620 12/28 (43%)
ANK 15 624..652 8/28 (29%)
ANK repeat 644..674 CDD:293786 4/29 (14%)
ANK 671..787 CDD:238125 41/115 (36%)
ANK 16 678..707 12/28 (43%)
ANK repeat 681..709 CDD:293786 12/27 (44%)
Ank_2 683..775 CDD:289560 36/91 (40%)
ANK repeat 711..742 CDD:293786 12/30 (40%)
ANK 17 711..740 12/28 (43%)
ANK repeat 744..775 CDD:293786 14/30 (47%)
ANK 18 744..773 14/28 (50%)
SAM_tankyrase1,2 871..936 CDD:188923 14/96 (15%)
SAM 877..933 CDD:197735 12/87 (14%)
tankyrase_like 938..1160 CDD:238718 32/147 (22%)
PARP 952..1155 CDD:279038 30/133 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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