back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank and hace1

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_012818577.2	Gene:	hace1 / 734146	XenbaseID:	XB-GENE-5757512	Length:	1012	Species:	Xenopus tropicalis

Alignment Length:	1020	Identity:	202/1020 - (19%)
Similarity:	342/1020 - (33%)	Gaps:	357/1020 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   426 GATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHL---AARANQADIIRILLRS 487
            |.:...||..:..|  |..:|.:...|:...:.:||. ..||.::.   ...|:|...:..||.:
Frog    59 GLSQYPGLPRMERA--MEQLNRLTRSLRRARTVELPE-DNETAVYTLMPMVMADQHRSVLELLSN 120

  Fly   488 AKVD---AIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVL 549
            :|.|   |..|..::.||:|:..|::..::|||:.||:.|.|.....:.||:||:.||:..:..|
Frog   121 SKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKRGADPNYQDISGCTPLHLAARNGQKKCMSKL 185

  Fly   550 LENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVEL 614
            ||..|:.|....:|.|.:|.....|:..::..|:|                    |..|..:.:.
Frog   186 LEYNADVNICNNEGLTAIHWLAVNGRTELLHDLVQ--------------------HVTNVDVEDA 230

  Fly   615 LLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQ 679
            :             ||.|:|:||:..:....:.||..|||:|..:.||.:||:.|...|..|..|
Frog   231 M-------------GQTALHVACQNGHKTTVLCLLDSGADINRPNVSGATPLYFACSHGQRDTAQ 282

  Fly   680 LLLEYGVISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVK 744
            :||..|......|||:|||.:..|.|:.....||::|                      |..|.:
Frog   283 ILLLRGAKYLPDKNGVTPLDLCVQGGYGETCDILIQH----------------------HPRLFQ 325

  Fly   745 FFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLGYVTVM 809
            ..|:...:.::..|.....|...:||..:..:.:|   .......|.:|:..|.|:|:  |...|
Frog   326 TLIQMTQNEDLRENTLRQVLEHLSQQSEVQYLKIL---TGLAEVATTNGHKLLSISSS--YEAQM 385

  Fly   810 ES-LKIV-----------TSTSVINS-----------------NIGAIEEKLKVMTPELMQETLL 845
            :| |:||           :|.:..|.                 |:..:..|:.:....|...||:
Frog   386 KSLLRIVRIFCHVFRIGPSSPNNGNDMGYNGNKTPRNQVFKVRNVYDVFRKINIKEMNLPNHTLI 450

  Fly   846 SDSDDESCD-DLLDHNHYKYM---ATD------D--------LKANYGQDQKNF---------DT 883
            ..:..|... :||.|:..:::   ||:      |        ||.|. .||::.         ::
Frog   451 YQATSEQDPLELLWHSLDEWLVLIATELTKNKRDSSNIACILLKQNQ-LDQQDISLAHQSAIGES 514

  Fly   884 TNTDH--------DLTDVSVLNKKEILPNEMSCIELT---------------------------- 912
            .:.||        |....|...|:|.:.:....|.:|
Frog   515 GSYDHLSSSTRAEDFESCSAAGKQEPVADGQDVISMTANRLSAVIQAFYMCCSCQMPQGMTSPRF 579

  Fly   913 -EIGHKPDNVV---IARSQV----HLGFLVSFLVDARGGSMRGYRHNGVRIIVPPKACAEPTRIT 969
             |...|.|:|:   :.|:..    |..||:.                          |.|   :.
Frog   580 IEFVCKHDDVLKCFVTRNPKIIFDHFHFLLE--------------------------CPE---LM 615

  Fly   970 CRYVKPQRVVNPPPLMEG-EALVSRILEMSPVDGMFLSPITLEVPHYGTLRKNEREIIILRSDN- 1032
            .|::   .::...|..|. |.....:|...|...|...|:            ||.:|:::..|:
Frog   616 SRFM---HIIKAQPFKERCEWFYEHLLAGQPDSDMVHRPV------------NENDILLVHRDSI 665

  Fly  1033 ------------------GESWREHNLYKDIIGEDINQTEEFHSDRIVRIVTQNVPHFFAVVSRV 1079
                              |.:.|.|.             ||.....:||       .:|.::|.
Frog   666 FRSSCEVVFKSNCEKLKQGIAVRFHG-------------EEGMGQGVVR-------EWFDILSS- 709

  Fly  1080 RQEVHVIGPD--------GGTVFSTAVPQVKAIFPPHALTKKIRVGLQAQSVDLVECSKLLGQGV 1136
                .:|.||        .||.|.   |...:...|..|......|            ::||..:
Frog   710 ----EIINPDYALFTQSADGTTFQ---PNSNSSVNPDHLNYFRFAG------------EILGLAL 755

  Fly  1137 AVSPVVTVEPRRRKFHKAITLSIPAPKACTNSMVNACYGNGNSSSPTLRLLCSISGGQTRATWED 1201
            ....:|.:. ..|.|:|.| |.||         ||                           ::|
Frog   756 YHRQLVNIY-FTRSFYKHI-LGIP---------VN---------------------------YQD 782

  Fly  1202 VTGSTPLSFVRDSVTFTTTVSARFWLIDCRNIIDAG-----RMATELYSHLAKVPFYVKFVIFAK 1261
            |....|        .:...:.   |::| .:|.|.|     .:.|:::..:.:||.
Frog   783 VASIDP--------EYAKNLQ---WILD-NDISDLGLELTFSVETDVFGAMEEVPL--------- 826

  Fly  1262 RISQTEAKFSVFCMTDDKEDKTLEQQEYFKEVAKSRDIEVLQNQI 1306
                .....|:....::|       .||.:.|.:.|....:|.||
Frog   827 ----KPGGASILVTQENK-------AEYVQLVTELRMTRAIQPQI 860

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.