DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank and ANKDD1B

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_016865303.1	Gene:	ANKDD1B / 728780	HGNCID:	32525	Length:	563	Species:	Homo sapiens

Alignment Length:	412	Identity:	109/412 - (26%)
Similarity:	193/412 - (46%)	Gaps:	43/412 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 GEHDEAA---HLLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLH 404
            ||.|.|.   .|||.|:           .:...||...::.:.:.|.:.|.|.|.......|.||
Human    53 GEEDTAVAGHELLLPNE-----------RSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALH 106

  Fly   405 IACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGE--- 466
            .|..:|.:..|:.|:||.|.:....:.|||.:|:|::.|.:.:::.|:  :|.||.   |.:
Human   107 FAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLV--KAGADQ---RAKNQV 166

  Fly   467 ----TPLH--LAARANQADIIRILLRSAKVDAIAREGQTPLHVASRLGNINIIMLLLQ--HGAEI 523
                ||..  |.....:.:::|.|..|....:: ::|.:.||.|::..::.|:..|:|  |..::
Human   167 GMWVTPGQKLLPHHCRREEVLRSLSISPTPGSL-QDGMSALHFATQSNHVRIVEYLIQDLHLKDL 230

  Fly   524 NAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGAS 588
            |...........:||:.|...:::.|.......:...|.|.|.||||.|:|....||:||.....
Human   231 NQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGHSPAVQVLLAQWQD 295

  Fly   589 IDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGA 653
            |:...:.:::.|.:||...:.|:|..||......:......:..:|:....|::.:...||....
Human   296 INEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQH 360

  Fly   654 DVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILL--- 714
            |::|:::...:|||:||..|||::|:.||:.|. :.|..|.|.|.|.||::..|.||..:|:
Human   361 DIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAE 425

  Fly   715 -------EHGANISERTRNGYT 729
                   ||..:|.:.: .|:|
Human   426 RYYAWREEHHESIRDPS-TGFT 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125
		ANK repeat	72..103	CDD:293786
		Ank_2	77..167	CDD:289560
		ANK repeat	105..136	CDD:293786
		ANK repeat	138..169	CDD:293786
		ANK	204..320	CDD:238125
		ANK repeat	204..231	CDD:293786
		Ank_2	205..295	CDD:289560
		ANK repeat	233..264	CDD:293786
		ANK repeat	266..295	CDD:293786
		ANK	294..419	CDD:238125	20/78 (26%)
		ANK repeat	299..330	CDD:293786
		Ank_4	300..353	CDD:290365	5/12 (42%)
		ANK repeat	332..363	CDD:293786	8/22 (36%)
		Ank_2	337..428	CDD:289560	24/87 (28%)
		ANK	360..485	CDD:238125	31/133 (23%)
		ANK repeat	365..395	CDD:293786	6/29 (21%)
		ANK repeat	398..427	CDD:293786	10/28 (36%)
		ANK repeat	431..462	CDD:293786	10/30 (33%)
		Ank_2	436..526	CDD:289560	23/100 (23%)
		ANK repeat	464..494	CDD:293786	7/38 (18%)
		ANK	491..616	CDD:238125	32/126 (25%)
		ANK repeat	496..527	CDD:293786	9/32 (28%)
		Ank_2	501..592	CDD:289560	26/92 (28%)
		ANK repeat	529..560	CDD:293786	4/30 (13%)
		ANK	557..682	CDD:238125	36/124 (29%)
		ANK repeat	562..590	CDD:293786	12/27 (44%)
		Ank_5	582..636	CDD:290568	11/53 (21%)
		ANK repeat	595..625	CDD:293786	7/29 (24%)
		ANK repeat	628..657	CDD:293786	5/28 (18%)
		Ank_2	633..723	CDD:289560	32/100 (32%)
		ANK repeat	661..691	CDD:293786	13/30 (43%)
		ANK	692..812	CDD:238125	15/48 (31%)
		ANK repeat	693..724	CDD:293786	12/40 (30%)
		Ank_2	698..788	CDD:289560	12/42 (29%)
		ANK repeat	726..755	CDD:293786	2/4 (50%)
		ANK repeat	759..788	CDD:293786
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
ANKDD1B	XP_016865303.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810