DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ank and Ankrd61

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001037762.1	Gene:	Ankrd61 / 689907	RGDID:	1586393	Length:	418	Species:	Rattus norvegicus

Alignment Length:	425	Identity:	111/425 - (26%)
Similarity:	176/425 - (41%)	Gaps:	138/425 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 LHLAARANQADIIRILLRSAKVDA-------------IAREGQT--PLHVASRLGNINIIMLLLQ 518
            |:.|......|.||.|||:..|:.             ::::.|.  |:|:|:.......::.|||
  Rat    32 LYEAIIKEDCDTIRTLLRNHPVNQPLTLLASSTGYRFLSQQTQPIFPIHLAAEYRKPQSLLCLLQ 96

  Fly   519 HGAEINAQSNDKYSALHI---------------------AAKEGQENIV---QVLLENGAENNAV 559
            |||:...:.....:.||:                     ...:.|.|.|   ::|.::||:.||.
  Rat    97 HGADPEVRDAQGLTTLHLMLLNWPVTSTTWTKPSTRIQKILTDIQNNAVLCLRILCDHGAQVNAR 161

  Fly   560 TKKG--FTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSP 622
            ....  .:|||||..||...|:..|.||||.::...::.:||||:|....|.:::|.|
  Rat   162 VDNSNKHSPLHLAITYGTYPVLSFLAQNGAQVNAINESSMTPLHMAADILNKNMIETL------- 219

  Fly   623 NLCARNGQCAIHIACKKNYLEIAMQLLQHGADVN-IISKSGFSPLHLAAQGGNVDMVQLLLEYGV 686
                        |||              ||:|| .||.:|.:.|.||                |
  Rat   220 ------------IAC--------------GANVNCAISSTGNTALKLA----------------V 242

  Fly   687 ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDA 751
            .:|::|.|..   :||..|.:   ::||.|||.:                            |..
  Rat   243 CTASSKAGRL---LAAGVGCI---RLLLNHGAQV----------------------------NAQ 273

  Fly   752 DIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHI----ASNLGYVTVMESL 812
            |.|     |.|.||:|...|..:||||||..:||.|.||::|.:.:::    :||:..||::..|
  Rat   274 DHE-----GQTALHEACFGGREVIINLLLEFEANVNILTRNGESPIYMYLQRSSNIRDVTLLARL 333

  Fly   813 KIVTSTSVINSNIGAIEEKLKVMTPE--LMQETLL 845
            ...|....:::..||:  ...:|.||  |::|||:
  Rat   334 LYRTYPLRLSNKQGAL--PAGIMLPEFHLLRETLI 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125
		ANK repeat	72..103	CDD:293786
		Ank_2	77..167	CDD:289560
		ANK repeat	105..136	CDD:293786
		ANK repeat	138..169	CDD:293786
		ANK	204..320	CDD:238125
		ANK repeat	204..231	CDD:293786
		Ank_2	205..295	CDD:289560
		ANK repeat	233..264	CDD:293786
		ANK repeat	266..295	CDD:293786
		ANK	294..419	CDD:238125
		ANK repeat	299..330	CDD:293786
		Ank_4	300..353	CDD:290365
		ANK repeat	332..363	CDD:293786
		Ank_2	337..428	CDD:289560
		ANK	360..485	CDD:238125	5/15 (33%)
		ANK repeat	365..395	CDD:293786
		ANK repeat	398..427	CDD:293786
		ANK repeat	431..462	CDD:293786
		Ank_2	436..526	CDD:289560	19/71 (27%)
		ANK repeat	464..494	CDD:293786	9/37 (24%)
		ANK	491..616	CDD:238125	40/165 (24%)
		ANK repeat	496..527	CDD:293786	10/32 (31%)
		Ank_2	501..592	CDD:289560	31/116 (27%)
		ANK repeat	529..560	CDD:293786	10/54 (19%)
		ANK	557..682	CDD:238125	36/127 (28%)
		ANK repeat	562..590	CDD:293786	13/29 (45%)
		Ank_5	582..636	CDD:290568	13/53 (25%)
		ANK repeat	595..625	CDD:293786	8/29 (28%)
		ANK repeat	628..657	CDD:293786	7/29 (24%)
		Ank_2	633..723	CDD:289560	25/90 (28%)
		ANK repeat	661..691	CDD:293786	6/29 (21%)
		ANK	692..812	CDD:238125	35/123 (28%)
		ANK repeat	693..724	CDD:293786	9/30 (30%)
		Ank_2	698..788	CDD:289560	25/89 (28%)
		ANK repeat	726..755	CDD:293786	2/28 (7%)
		ANK repeat	759..788	CDD:293786	14/28 (50%)
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
Ankrd61	NP_001037762.1	ANK 1	27..57		9/24 (38%)
		ANK	29..114	CDD:238125	20/81 (25%)
		ANK 2	74..103		10/28 (36%)
		ANK	78..220	CDD:238125	40/160 (25%)
		ANK repeat	78..105	CDD:293786	9/26 (35%)
		Ank_2	79..197	CDD:289560	31/117 (26%)
		ANK repeat	107..164	CDD:293786	10/56 (18%)
		ANK 3	131..160		6/28 (21%)
		ANK	164..297	CDD:238125	59/220 (27%)
		ANK 4	166..195		13/28 (46%)
		ANK repeat	168..197	CDD:293786	13/28 (46%)
		Ank_2	171..274	CDD:289560	46/185 (25%)
		ANK repeat	199..274	CDD:293786	34/157 (22%)
		ANK 5	199..228		14/61 (23%)
		ANK 6	233..272		16/88 (18%)
		Ank_5	263..316	CDD:290568	26/85 (31%)
		ANK repeat	276..305	CDD:293786	15/33 (45%)
		ANK 7	276..305		15/33 (45%)
		ANK 8	309..342		7/32 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900