DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank and Ankrd65

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001102897.1	Gene:	Ankrd65 / 680734	RGDID:	1588232	Length:	365	Species:	Rattus norvegicus

Alignment Length:	400	Identity:	121/400 - (30%)
Similarity:	172/400 - (43%)	Gaps:	101/400 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 ITP-----LHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPIL 327
            :||     |..|..||..||...||.:||.::.....|.||||.|...||..:::.|||:.|
  Rat    29 LTPQGWSTLFQAVWWGAPSLVMQLLRQGASVEERDHTGRTPLHLAVMRGHAPLVRLLLQRGA--- 90

  Fly   328 TKTKNGLSALHMAAQGEHDEAAHLLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANP 392
                       :|...:|...                   |.||.||..||..||
  Rat    91 -----------LAGAVDHTGR-------------------TPLHEAAWHGHSNVA---------- 115

  Fly   393 NARALNGFTPLHIACKKNRIKMVELLIKHGANIGA-TTESGLTPLHVASFMG-CINIVIYLLQHE 455
                                   |||::.||:..| .:::||||||.|:.:| .:.:..:....:
  Rat   116 -----------------------ELLLRRGASAAAPCSQTGLTPLHGAAALGRTLLVTCFTAAPD 157

  Fly   456 ASADLPTIRGETPLHLAARANQ---------------------------ADIIRILLR-SAKVDA 492
            :..|:..|||.|..|.||...|                           |..:|:||. .|||||
  Rat   158 SVPDVKDIRGWTATHWAAACGQLPVLELLTAGGSVDLDGALLVSAVAGSASALRLLLTLGAKVDA 222

  Fly   493 IAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENN 557
            :...|.|.|.:|:.||:...|.:||.|||:.|.:..:..||||.||..|....:|:|:..|.:.:
  Rat   223 LDSTGATALGLAAGLGHHQEIEVLLGHGADPNIRDRNNRSALHRAASGGCLRAIQLLVAKGTDVD 287

  Fly   558 AVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSP 622
            |....|.||||.|.:.|.:.||..||..||.:|..|....||||:|....:.:|:||||..|::|
  Rat   288 ARDSLGLTPLHYAARGGHREVVSHLLDRGAHVDAAGWLHKTPLHLAVECGHTTILELLLSRGANP 352

  Fly   623 NLCARNGQCA 632
            :|..:.|:.|
  Rat   353 SLRTQWGEVA 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125
		ANK repeat	72..103	CDD:293786
		Ank_2	77..167	CDD:289560
		ANK repeat	105..136	CDD:293786
		ANK repeat	138..169	CDD:293786
		ANK	204..320	CDD:238125	20/56 (36%)
		ANK repeat	204..231	CDD:293786
		Ank_2	205..295	CDD:289560	12/31 (39%)
		ANK repeat	233..264	CDD:293786
		ANK repeat	266..295	CDD:293786	12/31 (39%)
		ANK	294..419	CDD:238125	25/124 (20%)
		ANK repeat	299..330	CDD:293786	12/30 (40%)
		Ank_4	300..353	CDD:290365	14/52 (27%)
		ANK repeat	332..363	CDD:293786	2/30 (7%)
		Ank_2	337..428	CDD:289560	17/91 (19%)
		ANK	360..485	CDD:238125	34/153 (22%)
		ANK repeat	365..395	CDD:293786	9/29 (31%)
		ANK repeat	398..427	CDD:293786	5/28 (18%)
		ANK repeat	431..462	CDD:293786	9/31 (29%)
		Ank_2	436..526	CDD:289560	35/118 (30%)
		ANK repeat	464..494	CDD:293786	16/57 (28%)
		ANK	491..616	CDD:238125	49/124 (40%)
		ANK repeat	496..527	CDD:293786	13/30 (43%)
		Ank_2	501..592	CDD:289560	36/90 (40%)
		ANK repeat	529..560	CDD:293786	11/30 (37%)
		ANK	557..682	CDD:238125	30/75 (40%)
		ANK repeat	562..590	CDD:293786	13/27 (48%)
		Ank_5	582..636	CDD:290568	20/50 (40%)
		ANK repeat	595..625	CDD:293786	12/29 (41%)
		ANK repeat	628..657	CDD:293786	1/4 (25%)
		Ank_2	633..723	CDD:289560	120/399 (30%)
		ANK repeat	661..691	CDD:293786
		ANK	692..812	CDD:238125
		ANK repeat	693..724	CDD:293786
		Ank_2	698..788	CDD:289560
		ANK repeat	726..755	CDD:293786
		ANK repeat	759..788	CDD:293786
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
Ankrd65	NP_001102897.1	ANK	33..149	CDD:238125	47/181 (26%)
		ANK repeat	33..63	CDD:293786	10/29 (34%)
		Ank_2	37..123	CDD:289560	36/151 (24%)
		ANK repeat	65..96	CDD:293786	13/44 (30%)
		ANK repeat	98..123	CDD:293786	12/76 (16%)
		ANK repeat	197..224	CDD:293786	9/26 (35%)
		Ank_2	198..290	CDD:289560	33/91 (36%)
		ANK	221..346	CDD:238125	49/124 (40%)
		ANK repeat	227..257	CDD:293786	13/29 (45%)
		ANK repeat	259..290	CDD:293786	11/30 (37%)
		Ank_2	264..355	CDD:289560	36/90 (40%)
		ANK repeat	292..323	CDD:293786	14/30 (47%)
		ANK repeat	325..355	CDD:293786	12/29 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810