DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ank and Ankrd61

DIOPT Version :9

Sequence 1:NP_001162819.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_080008.1 Gene:Ankrd61 / 66729 MGIID:1913979 Length:421 Species:Mus musculus


Alignment Length:444 Identity:109/444 - (24%)
Similarity:186/444 - (41%) Gaps:83/444 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   338 HMAAQGEHDEAAHLLLDNKAPVDEVTVDYLTALH-------VAAHCGHVKVAKLLLDYKANPNAR 395
            ::..:|..|    |:.|....|:|   ...|.||       :...|..:|.  ||.::..|    
Mouse     3 NITKRGSRD----LVADGATLVEE---SLATTLHSKLYEAIIKEDCNTIKT--LLRNHPVN---- 54

  Fly   396 ALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADL 460
                 .||.|.....|.:::           :.....:.|:|:|:.......::.||||.|..::
Mouse    55 -----QPLTILANSTRYRLL-----------SQQTQPIFPIHLAAEYRKPQSLLCLLQHGADPEV 103

  Fly   461 PTIRGETPLHLAARANQADIIRILLRSAKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINA 525
            ...:|.|.|||......|........|.::..|..:.|.        ..:..:.:|..|||::||
Mouse   104 RDAQGFTTLHLMLLNWPASSTTWSKPSTQIQKILMDIQN--------NAVLCLCILCDHGAQVNA 160

  Fly   526 Q--SNDKYSALHIAAKEGQENIVQVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGAS 588
            :  :::|:||||:|...|...::..|.:|||:.||..:...||||:|.....:|:::.|:..||:
Mouse   161 RVDNSNKHSALHLAIIHGTYPVLSFLAQNGAQVNATNESSMTPLHMAADILNKNMIETLIAFGAN 225

  Fly   589 ID---FQGKNDVTPLHVATHYN--------NPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYL 642
            ::   ....|....|.|.|..:        ....:.|||.||:..|.....||.|:|.||.....
Mouse   226 VNCAISSTGNTALKLAVCTASSKVGRLLAAGVGCIRLLLNNGAQVNAQDHEGQTALHEACFGGRE 290

  Fly   643 EIAMQLLQHGADVNIISKSGFSPLHLAAQ-GGNVD----MVQLLLEYGVISAAAKNGLTPLHVAA 702
            .|...||:..|:|||::::|.||:::..| ..|:.    :.:||.....:..:.|.|:.|..:..
Mouse   291 AIISLLLEFEANVNILTRNGESPIYMYLQRSSNIRDRSLLARLLYRTYPLRLSNKQGILPAGIML 355

  Fly   703 QEGHVLVSQILLEHGANISERTRNGYTPLHMAA--------HYGHLDLVKFFIE 748
            .|     .|:|.|....:|::      ||.:.|        .||  :..||.:|
Mouse   356 PE-----YQLLRETLVKLSKK------PLTLEAICKRSIRNVYG--EKYKFHLE 396

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_001162819.1 ANK 67..192 CDD:238125
ANK repeat 72..103 CDD:293786
Ank_2 77..167 CDD:289560
ANK repeat 105..136 CDD:293786
ANK repeat 138..169 CDD:293786
ANK 204..320 CDD:238125
ANK repeat 204..231 CDD:293786
Ank_2 205..295 CDD:289560
ANK repeat 233..264 CDD:293786
ANK repeat 266..295 CDD:293786
ANK 294..419 CDD:238125 18/87 (21%)
ANK repeat 299..330 CDD:293786
Ank_4 300..353 CDD:290365 3/14 (21%)
ANK repeat 332..363 CDD:293786 6/24 (25%)
Ank_2 337..428 CDD:289560 18/96 (19%)
ANK 360..485 CDD:238125 27/131 (21%)
ANK repeat 365..395 CDD:293786 8/36 (22%)
ANK repeat 398..427 CDD:293786 4/28 (14%)
ANK repeat 431..462 CDD:293786 8/30 (27%)
Ank_2 436..526 CDD:289560 21/89 (24%)
ANK repeat 464..494 CDD:293786 7/29 (24%)
ANK 491..616 CDD:238125 35/137 (26%)
ANK repeat 496..527 CDD:293786 7/32 (22%)
Ank_2 501..592 CDD:289560 28/95 (29%)
ANK repeat 529..560 CDD:293786 13/30 (43%)
ANK 557..682 CDD:238125 40/140 (29%)
ANK repeat 562..590 CDD:293786 9/27 (33%)
Ank_5 582..636 CDD:290568 17/64 (27%)
ANK repeat 595..625 CDD:293786 10/37 (27%)
ANK repeat 628..657 CDD:293786 11/28 (39%)
Ank_2 633..723 CDD:289560 25/94 (27%)
ANK repeat 661..691 CDD:293786 7/34 (21%)
ANK 692..812 CDD:238125 16/65 (25%)
ANK repeat 693..724 CDD:293786 7/30 (23%)
Ank_2 698..788 CDD:289560 13/59 (22%)
ANK repeat 726..755 CDD:293786 8/31 (26%)
ANK repeat 759..788 CDD:293786
ZU5 930..1034 CDD:128514
Death_ank 1439..1521 CDD:260029
Ankrd61NP_080008.1 ANK 1 27..57 7/40 (18%)
ANK <32..114 CDD:238125 20/103 (19%)
ANK 2 74..103 8/28 (29%)
ANK 78..220 CDD:238125 42/149 (28%)
ANK repeat 78..105 CDD:293786 8/26 (31%)
Ank_2 79..197 CDD:289560 35/125 (28%)
ANK repeat 107..164 CDD:293786 15/64 (23%)
ANK 3 107..146 9/46 (20%)
ANK 164..297 CDD:238125 39/132 (30%)
ANK 4 166..195 11/28 (39%)
ANK repeat 168..197 CDD:293786 12/28 (43%)
Ank_2 171..274 CDD:289560 29/102 (28%)
ANK repeat 199..274 CDD:293786 19/74 (26%)
ANK 5 199..228 9/28 (32%)
ANK 6 233..272 9/38 (24%)
Ank_5 262..316 CDD:290568 22/53 (42%)
ANK repeat 276..305 CDD:293786 11/28 (39%)
ANK 7 276..305 11/28 (39%)
ANK 8 309..342 7/32 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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