DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank and ANKEF1

DIOPT Version :9

Sequence 1:NP_001162819.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_071379.3 Gene:ANKEF1 / 63926 HGNCID:15803 Length:776 Species:Homo sapiens


Alignment Length:801 Identity:188/801 - (23%)
Similarity:314/801 - (39%) Gaps:183/801 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 MALDNKNGIIKQNDATISFLRAARSGDIKKVMDFLDCGEISDINSCN-ANGLNALHLAAKDGYVD 87
            |||.:|.   .:|......|:..|:.|.|::......|....||... .|||:|||||:....:|
Human     1 MALADKR---LENLQIYKVLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSNDID 62

  Fly    88 ICCELLRRGIKIDNATKKGNTALHIASLAGQHDVINQLIL------------------------- 127
            :...||..|...|...:.|.|....|:..| |::..:::.                         
Human    63 MVSFLLDLGAHPDVQDRMGCTPTMRAAELG-HELSMEILAKAKADMTIVDNEGKGVLFYCILPTK 126

  Fly   128 -----------YNANVNVQSLNGFTPLYM-AAQENHD--NCCRTLLANGANP-SLSTEDGFTPLA 177
                       :.|:||..:..| .|::: |.::.||  :.|.|.|..|||| ::::..|.|.|.
Human   127 RHYRCALIALEHGADVNNSTYEG-KPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALM 190

  Fly   178 VAMQQGHDKIVAVLLENDVRGKV------RLPALHIAAKKNDVNAAKLLLQHDPNADIVSKSGFT 236
            .|.::|..:||..:||..  |:|      |..|.|.|||....:..|||..::.:..::|.:|.|
Human   191 EASREGVVEIVRGILERG--GEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNT 253

  Fly   237 PLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKIDAATRDGL 301
            |||.||..|..|....:.....|:.:....:.||..||.:.|              ..||:::  
Human   254 PLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGG--------------FKAASKE-- 302

  Fly   302 TPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHD---EAAHLLLDNKAPVD--- 360
              :..|.|     :...|.:..|    |..|.|.||.:     ||   |....|.:..|.:|   
Human   303 --IRRAER-----IANKLARPGA----KNPNPLWALRL-----HDWSVEREAFLREAFAVLDRGD 351

  Fly   361 ------------EVTVDYLTA--------LHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHI 405
                        |...||.::        ||.....|.|.:.:.....:....:..|..:.|.  
Human   352 GSISKNDFVMVLEERQDYASSEQLAAIAHLHEKTRGGGVNINEFFKGTRYLNKSFVLGSYGPK-- 414

  Fly   406 ACKKNRIKMVELLIKHGANIGATTESG--LTPLHVASFMGCINIVIYLLQHEASADLPTIRGETP 468
              ||.:            .:|...:.|  :.||.:     |: |..|..........|....||.
Human   415 --KKEK------------GMGKKGKKGKFVLPLPI-----CV-IPEYAFPRRQDGGPPYYMIETY 459

  Fly   469 LHL--AARAN---------QADIIRILLRSAKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAE 522
            .::  ::|.|         |.|.:..:..|.||       .:.:::.::.|::..:....:.|..
Human   460 KNVTDSSRFNRDHPPEHPIQDDSVWYIDDSEKV-------FSNINIITKAGDLASLKKAFESGIP 517

  Fly   523 INAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGA 587
            ::.:.|...:.|..|...|..::|:.|||.||..||.....:||||.||..|:|::|::|:::||
Human   518 VDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGA 582

  Fly   588 SIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEI-AMQLLQH 651
            .||....|:.|||:.|........|:.||..|:...|..|.|..|:.:|  |.|.:. .:.|::.
Human   583 LIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVA--KAYADYRIIDLIKE 645

  Fly   652 GADVNIISKS------GFSPLHLAAQGGNVDMVQLLLE--YGVISAAAKNGLTPLHVAAQEGHVL 708
            ..| |:...:      |.:|..|..:|..:...:.||.  |||.:.:...       ..|:|:|:
Human   646 KLD-NLPKPAENQKLKGKTPPILKTEGPEIKKEEELLSSIYGVPTTSEGK-------KVQKGNVV 702

  Fly   709 VSQILLEHGANISERTRNGYT 729
                      :::....:|||
Human   703 ----------HLNSLITSGYT 713

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_001162819.1 ANK 67..192 CDD:238125 41/165 (25%)
ANK repeat 72..103 CDD:293786 13/30 (43%)
Ank_2 77..167 CDD:289560 29/129 (22%)
ANK repeat 105..136 CDD:293786 8/66 (12%)
ANK repeat 138..169 CDD:293786 12/34 (35%)
ANK 204..320 CDD:238125 28/115 (24%)
ANK repeat 204..231 CDD:293786 8/26 (31%)
Ank_2 205..295 CDD:289560 23/89 (26%)
ANK repeat 233..264 CDD:293786 10/30 (33%)
ANK repeat 266..295 CDD:293786 5/28 (18%)
ANK 294..419 CDD:238125 28/150 (19%)
ANK repeat 299..330 CDD:293786 4/30 (13%)
Ank_4 300..353 CDD:290365 12/55 (22%)
ANK repeat 332..363 CDD:293786 11/48 (23%)
Ank_2 337..428 CDD:289560 19/116 (16%)
ANK 360..485 CDD:238125 26/160 (16%)
ANK repeat 365..395 CDD:293786 6/37 (16%)
ANK repeat 398..427 CDD:293786 3/28 (11%)
ANK repeat 431..462 CDD:293786 6/32 (19%)
Ank_2 436..526 CDD:289560 16/100 (16%)
ANK repeat 464..494 CDD:293786 9/40 (23%)
ANK 491..616 CDD:238125 34/124 (27%)
ANK repeat 496..527 CDD:293786 2/30 (7%)
Ank_2 501..592 CDD:289560 28/90 (31%)
ANK repeat 529..560 CDD:293786 11/30 (37%)
ANK 557..682 CDD:238125 39/131 (30%)
ANK repeat 562..590 CDD:293786 12/27 (44%)
Ank_5 582..636 CDD:290568 18/53 (34%)
ANK repeat 595..625 CDD:293786 9/29 (31%)
ANK repeat 628..657 CDD:293786 7/29 (24%)
Ank_2 633..723 CDD:289560 18/98 (18%)
ANK repeat 661..691 CDD:293786 9/37 (24%)
ANK 692..812 CDD:238125 6/38 (16%)
ANK repeat 693..724 CDD:293786 3/30 (10%)
Ank_2 698..788 CDD:289560 6/32 (19%)
ANK repeat 726..755 CDD:293786 3/4 (75%)
ANK repeat 759..788 CDD:293786
ZU5 930..1034 CDD:128514
Death_ank 1439..1521 CDD:260029
ANKEF1NP_071379.3 Ank 47..79 CDD:278452 13/31 (42%)
ANK repeat 47..78 CDD:293786 13/30 (43%)
ANK 1 47..76 12/28 (43%)
Ank_2 52..143 CDD:289560 15/91 (16%)
ANK repeat 80..111 CDD:293786 5/31 (16%)
ANK repeat 113..143 CDD:293786 1/29 (3%)
ANK 143..270 CDD:238125 43/129 (33%)
ANK 2 184..213 11/30 (37%)
ANK repeat 185..215 CDD:293786 11/31 (35%)
Ank_2 189..277 CDD:289560 28/89 (31%)
ANK repeat 217..248 CDD:293786 9/30 (30%)
ANK 3 217..246 9/28 (32%)
ANK repeat 250..281 CDD:293786 10/30 (33%)
ANK 4 250..279 10/28 (36%)
Ank_2 255..>312 CDD:289560 16/79 (20%)
EFh 340..395 CDD:298682 10/54 (19%)
Ank_4 501..545 CDD:290365 7/43 (16%)
ANK 519..643 CDD:238125 42/125 (34%)
ANK 5 524..553 9/28 (32%)
ANK repeat 527..555 CDD:293786 11/27 (41%)
Ank_2 529..621 CDD:289560 35/91 (38%)
ANK repeat 557..588 CDD:293786 14/30 (47%)
ANK 6 557..586 13/28 (46%)
ANK repeat 590..621 CDD:293786 10/30 (33%)
ANK 7 590..619 9/28 (32%)
ANK 8 623..652 8/31 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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