DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank and ankdd1a

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001092718.1	Gene:	ankdd1a / 569271	ZFINID:	ZDB-GENE-070615-8	Length:	489	Species:	Danio rerio

Alignment Length:	382	Identity:	104/382 - (27%)
Similarity:	191/382 - (50%)	Gaps:	36/382 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 HCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAPVDEVTVDYLTA 369
            |.|::....|.::.|:.:...|..|.|....|||.||....::|..||||:...||::....:.|
Zfish    20 HDAAKRNDTERMQELISRGVDIKVKNKMDRKALHWAAGAGSEQALRLLLDHDMDVDDMDSFGMNA 84

  Fly   370 LHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLT 434
            |.:||..||:.:.|                                 :|:..||.:....::||.
Zfish    85 LLLAAWFGHLTILK---------------------------------ILVSTGAKLTTENKNGLN 116

  Fly   435 PLHVASFMGCINIVIYLLQHEASADLPTIR--GETPLHLAARANQADIIRILLRSAKVDAIA-RE 496
            .||.|:..|.|.|:.|:::...:..|..:.  |:|..||||.....:::..|:.......:. :.
Zfish   117 LLHCAAQRGHITILEYIMEDLENVQLNKVENSGKTAFHLAAEHGHLEVVEFLIGMGCAHNLKDKH 181

  Fly   497 GQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTK 561
            |.|.||:|::.|:.:::..:::.|..|:.::.|..:|||:|::.|....:::|||.|...|.:|.
Zfish   182 GNTALHLAAKQGHSDVLQKIMETGENIDERNIDGMTALHLASEGGHYECIRLLLEAGCNVNELTD 246

  Fly   562 KGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCA 626
            ...|.|||..::...:.|::|:|.|.::|......|:.||:|...|:..||:.|::.|...::..
Zfish   247 SKRTALHLVAQHASASEVRLLIQAGINLDSVDTQHVSALHLAVLNNSTEIVKDLIEAGCDLDIFD 311

  Fly   627 RNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLE 683
            ...|.|:|||.:...|.||..:|..|.::|::.|.|.|.|.:||:|.:|::|.::::
Zfish   312 NRLQTALHIAAEHGRLNIAETILISGVNLNLLDKQGKSSLDVAARGNHVNVVDMIIK 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125
		ANK repeat	72..103	CDD:293786
		Ank_2	77..167	CDD:289560
		ANK repeat	105..136	CDD:293786
		ANK repeat	138..169	CDD:293786
		ANK	204..320	CDD:238125	3/14 (21%)
		ANK repeat	204..231	CDD:293786
		Ank_2	205..295	CDD:289560
		ANK repeat	233..264	CDD:293786
		ANK repeat	266..295	CDD:293786
		ANK	294..419	CDD:238125	26/113 (23%)
		ANK repeat	299..330	CDD:293786	5/24 (21%)
		Ank_4	300..353	CDD:290365	14/47 (30%)
		ANK repeat	332..363	CDD:293786	12/30 (40%)
		Ank_2	337..428	CDD:289560	21/90 (23%)
		ANK	360..485	CDD:238125	27/126 (21%)
		ANK repeat	365..395	CDD:293786	7/29 (24%)
		ANK repeat	398..427	CDD:293786	3/28 (11%)
		ANK repeat	431..462	CDD:293786	10/30 (33%)
		Ank_2	436..526	CDD:289560	23/92 (25%)
		ANK repeat	464..494	CDD:293786	7/31 (23%)
		ANK	491..616	CDD:238125	36/125 (29%)
		ANK repeat	496..527	CDD:293786	8/30 (27%)
		Ank_2	501..592	CDD:289560	27/90 (30%)
		ANK repeat	529..560	CDD:293786	11/30 (37%)
		ANK	557..682	CDD:238125	40/124 (32%)
		ANK repeat	562..590	CDD:293786	8/27 (30%)
		Ank_5	582..636	CDD:290568	16/53 (30%)
		ANK repeat	595..625	CDD:293786	9/29 (31%)
		ANK repeat	628..657	CDD:293786	10/28 (36%)
		Ank_2	633..723	CDD:289560	18/51 (35%)
		ANK repeat	661..691	CDD:293786	8/23 (35%)
		ANK	692..812	CDD:238125
		ANK repeat	693..724	CDD:293786
		Ank_2	698..788	CDD:289560
		ANK repeat	726..755	CDD:293786
		ANK repeat	759..788	CDD:293786
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
ankdd1a	NP_001092718.1	ANK	19..134	CDD:238125	38/146 (26%)
		Ank_2	19..111	CDD:289560	29/123 (24%)
		ANK repeat	19..45	CDD:293786	5/24 (21%)
		ANK repeat	47..78	CDD:293786	12/30 (40%)
		ANK	79..202	CDD:238125	33/155 (21%)
		ANK repeat	80..111	CDD:293786	10/63 (16%)
		Ank_2	85..179	CDD:289560	26/126 (21%)
		ANK repeat	113..146	CDD:293786	10/32 (31%)
		ANK	143..268	CDD:238125	32/124 (26%)
		ANK repeat	148..179	CDD:293786	7/30 (23%)
		Ank_2	153..242	CDD:289560	23/88 (26%)
		ANK repeat	181..212	CDD:293786	8/30 (27%)
		ANK	209..334	CDD:238125	38/124 (31%)
		ANK repeat	214..242	CDD:293786	10/27 (37%)
		ANK repeat	247..278	CDD:293786	9/30 (30%)
		Ank_2	252..344	CDD:289560	28/91 (31%)
		ANK repeat	280..311	CDD:293786	9/30 (30%)
		ANK repeat	313..344	CDD:293786	11/30 (37%)
		DD	402..474	CDD:301326
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000