DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank and ankef1a

DIOPT Version :9

Sequence 1:NP_001162819.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_001020714.1 Gene:ankef1a / 566413 ZFINID:ZDB-GENE-041001-196 Length:779 Species:Danio rerio


Alignment Length:652 Identity:159/652 - (24%)
Similarity:259/652 - (39%) Gaps:95/652 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 LRAARSGD---IKKVM-----DFLDCGEISDINSCNANGLNALHLAAKDGYVDICCELLRRGIKI 99
            |:..:.||   |:|::     |.::..|..|     .||:  |||||.....|:...|:.:|.:.
Zfish    19 LQCIQDGDKTYIEKLISMGVDDLINLTEPRD-----GNGV--LHLAAVTNKPDMLEFLVDQGARP 76

  Fly   100 DNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPLY--MAAQENHDNCCRTLLANG 162
            |...:.|.|.|.:|:..|...:::.|...||::.:..:.|...|:  :...:.|..|.:.:|...
Zfish    77 DVQDRSGRTPLMLAAELGYDGIVSLLAKKNADMKLVDIEGKGVLFYCLHPTKRHMRCLQVVLNGN 141

  Fly   163 ANPSLSTEDGFTPLAVAMQQGHD--KIVAVLLE--------NDVRGKVRLPALHIAAKKNDVNAA 217
            |:.:..:|.|.....:|.:|..|  .:...:||        |...|:.   ||..||:...:...
Zfish   142 ADVNNVSEAGIPVFLLACEQAQDCEGMCLSILERGADPNATNQETGRT---ALMEAARAGALELV 203

  Fly   218 KLLLQHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSL 282
            :.:|:...|.:.:.|..|...|.||..|..:|..:|...:|||..|.....||||.|...|....
Zfish   204 RAILKKGGNVNALDKKRFHAAHFAAEKGFFEIIKVLSAYRADVGGVTTEGDTPLHFAASGGYTDC 268

  Fly   283 CTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSA-----LH-MAA 341
            |..|..||.......::||.|...|...||...:|.|.:........:|.|.:.     || .:.
Zfish   269 CRFLAQRGCNPKLKNQEGLLPRQIAKDCGHKATVKELKKAERLHGKSSKGGTNGPWALMLHDWSH 333

  Fly   342 QGEHD-----EAA----------------HLLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLL 385
            :.|::     |:|                .:|.:..||:|:|.:..|.........|.:.:...|
Zfish   334 ENENELRSAFESATDGFIGVEFVPKGTFVSVLKELHAPLDDVQIHILLLALDKRREGFININDFL 398

  Fly   386 LDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLT-PLHVASFM------- 442
            ...|..|....:..:.|     ||          |..|..|.|.:|... ||.:.:..       
Zfish   399 RGLKYLPKTYVMASYGP-----KK----------KKAAKAGKTKKSKFNLPLPICTVPQDLIHRR 448

  Fly   443 ---GCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIRILLRSAKVDAIAREGQTPLHVA 504
               |..:.:|...||...    |.|.:.. |...|..:.|....:....|:       ...|:..
Zfish   449 DDGGPPHFMIESWQHATD----TQRYDRD-HRPERPIEDDTAWYIDEPEKI-------YINLNYC 501

  Fly   505 SRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTKKGFTPLHL 569
            .:.|:|..:.|.|.....::.:.....:.|..|...|...:.:.||:|||:.||..:..:||||.
Zfish   502 VKTGDIESLRLALSQKVPVDVKDRFYKTPLMAACASGNYEMAKFLLDNGADVNACDQFKWTPLHH 566

  Fly   570 ACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIH 634
            ||..|:.:::|:||:.|||:|....|..|||..|.....||.||.|:|.|:..|...:..|..:.
Zfish   567 ACHAGQLDIIQLLLEAGASVDRPALNGATPLMRAIESCRPSCVEYLIKAGAKINAVNKTEQNCLD 631

  Fly   635 IA 636
            :|
Zfish   632 VA 633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_001162819.1 ANK 67..192 CDD:238125 30/128 (23%)
ANK repeat 72..103 CDD:293786 11/30 (37%)
Ank_2 77..167 CDD:289560 23/91 (25%)
ANK repeat 105..136 CDD:293786 8/30 (27%)
ANK repeat 138..169 CDD:293786 6/32 (19%)
ANK 204..320 CDD:238125 35/115 (30%)
ANK repeat 204..231 CDD:293786 6/26 (23%)
Ank_2 205..295 CDD:289560 27/89 (30%)
ANK repeat 233..264 CDD:293786 10/30 (33%)
ANK repeat 266..295 CDD:293786 10/28 (36%)
ANK 294..419 CDD:238125 28/151 (19%)
ANK repeat 299..330 CDD:293786 8/30 (27%)
Ank_4 300..353 CDD:290365 15/79 (19%)
ANK repeat 332..363 CDD:293786 10/57 (18%)
Ank_2 337..428 CDD:289560 21/112 (19%)
ANK 360..485 CDD:238125 26/135 (19%)
ANK repeat 365..395 CDD:293786 5/29 (17%)
ANK repeat 398..427 CDD:293786 5/28 (18%)
ANK repeat 431..462 CDD:293786 7/41 (17%)
Ank_2 436..526 CDD:289560 16/99 (16%)
ANK repeat 464..494 CDD:293786 5/29 (17%)
ANK 491..616 CDD:238125 38/124 (31%)
ANK repeat 496..527 CDD:293786 5/30 (17%)
Ank_2 501..592 CDD:289560 29/90 (32%)
ANK repeat 529..560 CDD:293786 10/30 (33%)
ANK 557..682 CDD:238125 31/80 (39%)
ANK repeat 562..590 CDD:293786 13/27 (48%)
Ank_5 582..636 CDD:290568 20/53 (38%)
ANK repeat 595..625 CDD:293786 13/29 (45%)
ANK repeat 628..657 CDD:293786 2/9 (22%)
Ank_2 633..723 CDD:289560 1/4 (25%)
ANK repeat 661..691 CDD:293786
ANK 692..812 CDD:238125
ANK repeat 693..724 CDD:293786
Ank_2 698..788 CDD:289560
ANK repeat 726..755 CDD:293786
ANK repeat 759..788 CDD:293786
ZU5 930..1034 CDD:128514
Death_ank 1439..1521 CDD:260029
ankef1aNP_001020714.1 Ank_2 18..113 CDD:372319 27/100 (27%)
ANK repeat 18..46 CDD:293786 6/26 (23%)
ANK repeat 49..80 CDD:293786 12/37 (32%)
ANK repeat 82..183 CDD:293786 21/100 (21%)
PHA02874 85..>293 CDD:165205 53/210 (25%)
ANK repeat 187..217 CDD:293786 7/32 (22%)
Ank_2 191..283 CDD:372319 27/91 (30%)
ANK repeat 219..250 CDD:293786 10/30 (33%)
ANK repeat 252..283 CDD:293786 10/30 (33%)
ANK repeat 498..524 CDD:293786 5/25 (20%)
PHA02874 <508..>739 CDD:165205 41/126 (33%)
ANK repeat 529..557 CDD:293786 10/27 (37%)
Ank_2 531..623 CDD:372319 37/91 (41%)
ANK repeat 559..590 CDD:293786 14/30 (47%)
ANK repeat 592..623 CDD:293786 13/30 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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