DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank and caiap

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001020663.1	Gene:	caiap / 557416	ZFINID:	ZDB-GENE-041014-19	Length:	744	Species:	Danio rerio

Alignment Length:	730	Identity:	198/730 - (27%)
Similarity:	312/730 - (42%)	Gaps:	143/730 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 GQHDVINQLILYNANVNVQSL------NGFTPLYMAAQENHDNCCRTLLANGANPSLSTEDGFTP 175
            |..|...|||.|....:.|.|      ....|...|.:.|::...:.:|.:.:|
Zfish   104 GIRDARRQLIGYLLEKDKQGLVKNSKPERIHPKSTANEPNNEPLNKQILKSESN----------- 157

  Fly   176 LAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAKLLLQHDPNADIVSKSGFTPLHI 240
                   .||.|:..:...|      |..|....|:.|||:             |..|..|.||.
Zfish   158 -------HHDAILEAISSGD------LYLLQELTKELDVNS-------------VLSSNDTLLHH 196

  Fly   241 AAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLH 305
            ||.||...|...||...|.::...|...|.||.|.:.|..::...|...||.|.|..:...||||
Zfish   197 AAEYGKEAIVYFLLRQGAKLDLKDKEGRTALHRAAQRGHTAVAVALAKAGADIHATDQTSKTPLH 261

  Fly   306 CASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAPVDEVTVDYLTAL 370
            .|:::||...:|.|:.:....|   ||..:.|||||..::...|.:||.|.|.||.......|||
Zfish   262 LAAQNGHEGCVKALVHEEKKSL---KNQTTVLHMAAIEDNATLAEVLLRNGALVDAQDGQRKTAL 323

  Fly   371 HVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTP 435
            |.|...|:.|.|.:||...|..::|.::.      |.:.||..::.|.::|
Zfish   324 HHAVRHGNEKTAAVLLKAGAQVDSRIVDA------AFQLNRKSLLSLFLQH-------------- 368

  Fly   436 LHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIRILLRSAK--VDAIAREGQ 498
                             .||:                  .:|.:|...|.::.:  :||
Zfish   369 -----------------VHES------------------MSQTEINAALFKAVQRNLDA------ 392

  Fly   499 TPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTKKG 563
                         ::..|::|||::|:.:...|:.:.:||:.|.....:||:...|:.:......
Zfish   393 -------------VVAALIEHGADVNSCNELGYTPVLLAAELGNGEAFKVLVSKKAKLDERLPNQ 444

  Fly   564 FTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARN 628
            .:.||||.:.|...:.||||..|...:..|..|.||||::..:|.|:::.|||:.|:..|...::
Zfish   445 MSSLHLAVQSGSIQIAQILLHKGIDPNISGPKDQTPLHLSASHNQPAMMALLLRVGAQLNPVTQD 509

  Fly   629 GQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGVIS-AAAK 692
            |...:|:|.:..:.|...|||:..|||:...|.|.:.||.||:.|.|.::|.||..|..| |:.:
Zfish   510 GFTPLHLASQNGHTEAVAQLLEAKADVHAKDKQGRTALHWAAEQGEVAIIQSLLAAGAYSNASER 574

  Fly   693 NGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSS 757
            ...||||:||.|||......||...|.:..:..:|.:|||.||..|.        |....:.::|
Zfish   575 EKKTPLHLAAAEGHTKAVSALLAGKAKVGAKDMDGCSPLHYAARNGK--------ERAGSVLLAS 631

  Fly   758 ----NIG------YTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLGYVTVMESL 812
                |:.      .|.||.||:.||..::.:||.:||..|||..:.:|.||.|...|::..::
Zfish   632 SKSKNVDDKNVWRRTALHLAAEHGHEALVGILLENKAKINALDNNKDTPLHCACKTGHLGTVQ-- 694

  Fly   813 KIVTSTSVINSNIGA 827
            :::..|:...:|:.|
Zfish   695 RLINWTNGERANLQA 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125	16/80 (20%)
		ANK repeat	72..103	CDD:293786
		Ank_2	77..167	CDD:289560	13/55 (24%)
		ANK repeat	105..136	CDD:293786	6/18 (33%)
		ANK repeat	138..169	CDD:293786	5/30 (17%)
		ANK	204..320	CDD:238125	37/115 (32%)
		ANK repeat	204..231	CDD:293786	5/26 (19%)
		Ank_2	205..295	CDD:289560	28/89 (31%)
		ANK repeat	233..264	CDD:293786	12/30 (40%)
		ANK repeat	266..295	CDD:293786	9/28 (32%)
		ANK	294..419	CDD:238125	41/124 (33%)
		ANK repeat	299..330	CDD:293786	10/30 (33%)
		Ank_4	300..353	CDD:290365	18/52 (35%)
		ANK repeat	332..363	CDD:293786	13/30 (43%)
		Ank_2	337..428	CDD:289560	29/90 (32%)
		ANK	360..485	CDD:238125	22/124 (18%)
		ANK repeat	365..395	CDD:293786	11/29 (38%)
		ANK repeat	398..427	CDD:293786	5/28 (18%)
		ANK repeat	431..462	CDD:293786	2/30 (7%)
		Ank_2	436..526	CDD:289560	12/91 (13%)
		ANK repeat	464..494	CDD:293786	5/31 (16%)
		ANK	491..616	CDD:238125	33/124 (27%)
		ANK repeat	496..527	CDD:293786	5/30 (17%)
		Ank_2	501..592	CDD:289560	22/90 (24%)
		ANK repeat	529..560	CDD:293786	7/30 (23%)
		ANK	557..682	CDD:238125	42/124 (34%)
		ANK repeat	562..590	CDD:293786	10/27 (37%)
		Ank_5	582..636	CDD:290568	18/53 (34%)
		ANK repeat	595..625	CDD:293786	12/29 (41%)
		ANK repeat	628..657	CDD:293786	10/28 (36%)
		Ank_2	633..723	CDD:289560	35/90 (39%)
		ANK repeat	661..691	CDD:293786	13/30 (43%)
		ANK	692..812	CDD:238125	41/129 (32%)
		ANK repeat	693..724	CDD:293786	12/30 (40%)
		Ank_2	698..788	CDD:289560	31/99 (31%)
		ANK repeat	726..755	CDD:293786	8/28 (29%)
		ANK repeat	759..788	CDD:293786	11/34 (32%)
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
caiap	NP_001020663.1	CARD	15..94	CDD:260018
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..146		3/18 (17%)
		ANK 1. /evidence=ECO:0000255	157..185		10/51 (20%)
		ANK repeat	159..187	CDD:293786	10/46 (22%)
		PHA03095	160..>577	CDD:222980	140/512 (27%)
		ANK 2. /evidence=ECO:0000255	189..218		12/28 (43%)
		ANK repeat	191..220	CDD:293786	11/28 (39%)
		ANK repeat	222..253	CDD:293786	10/30 (33%)
		ANK 3. /evidence=ECO:0000255	222..251		9/28 (32%)
		ANK 4. /evidence=ECO:0000255	255..285		10/32 (31%)
		ANK 5. /evidence=ECO:0000255	287..314		11/26 (42%)
		ANK repeat	318..348	CDD:293786	11/29 (38%)
		ANK 6. /evidence=ECO:0000255	318..347		11/28 (39%)
		ANK 7. /evidence=ECO:0000255	377..406		8/47 (17%)
		ANK repeat	379..408	CDD:293786	8/47 (17%)
		ANK repeat	410..441	CDD:293786	7/30 (23%)
		ANK 8. /evidence=ECO:0000255	410..439		7/28 (25%)
		ANK 9. /evidence=ECO:0000255	443..472		10/28 (36%)
		ANK repeat	446..474	CDD:293786	10/27 (37%)
		PHA03095	463..>698	CDD:222980	81/244 (33%)
		ANK 10. /evidence=ECO:0000255	476..505		11/28 (39%)
		ANK repeat	478..507	CDD:293786	11/28 (39%)
		ANK repeat	509..540	CDD:293786	10/30 (33%)
		ANK 11. /evidence=ECO:0000255	509..538		10/28 (36%)
		ANK repeat	542..573	CDD:293786	13/30 (43%)
		ANK 12. /evidence=ECO:0000255	542..571		12/28 (43%)
		ANK repeat	575..606	CDD:293786	12/30 (40%)
		ANK 13. /evidence=ECO:0000255	575..604		12/28 (43%)
		ANK repeat	608..639	CDD:293786	10/38 (26%)
		ANK 14. /evidence=ECO:0000255	608..637		9/36 (25%)
		ANK repeat	641..674	CDD:293786	13/32 (41%)
		ANK 15. /evidence=ECO:0000255	643..672		11/28 (39%)
		ANK repeat	676..711	CDD:293786	8/36 (22%)
		ANK 16. /evidence=ECO:0000255	676..705		6/30 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593753
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1011028at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750