DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank and PIDD1

DIOPT Version :9

Sequence 1:NP_001162819.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:XP_005253062.1 Gene:PIDD1 / 55367 HGNCID:16491 Length:934 Species:Homo sapiens


Alignment Length:1063 Identity:244/1063 - (22%)
Similarity:388/1063 - (36%) Gaps:288/1063 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   567 LHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQC 631
            |||..    |..:|:|     .::|        |.::|| .:|.::|..|........|.|:   
Human    51 LHLCV----QQPLQLL-----QVEF--------LRLSTH-EDPQLLEATLAQLPQSLSCLRS--- 94

  Fly   632 AIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPL-HLAAQGGNVDMVQLLLEYGVISAAAKNGL 695
               :..|.......:.....||..|:  .:|.|.| |||    ::|:....||           .
Human    95 ---LVLKGGQRRDTLGACLRGALTNL--PAGLSGLAHLA----HLDLSFNSLE-----------T 139

  Fly   696 TPLHVAAQEGHVLVSQILLEHGANISER---------------TRNGYTPLHMAAHYGHLDLVKF 745
            .|..|....|   :..:||.|.. :||.               |.|....|..|  .|.|..:: 
Human   140 LPACVLQMRG---LGALLLSHNC-LSELPEALGALPALTFLTVTHNRLQTLPPA--LGALSTLQ- 197

  Fly   746 FIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLL-RHKANPNALTKDGNTALHIASNLGYVTVM 809
                  .:::|.|:..|...:....|.::.:||.. |.::.|.:|..                 :
Human   198 ------RLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAG-----------------L 239

  Fly   810 ESLKIVTSTSVINSNIGAIEEKLKVMTPELMQETLLSDSDDESCDDLLDHNHYKYMATDDLKANY 874
            .||:::    |::||:      |..:..:|.:..||:..|       |..|..:.:..:.|.|.:
Human   240 RSLRLL----VLHSNL------LASVPADLARLPLLTRLD-------LRDNQLRDLPPELLDAPF 287

  Fly   875 GQDQKN-FDTTNTDHDLTDVSVLNKKEILPNEMSCIELTEIGHKPDNVVIARSQVHLGFLVSFLV 938
            .:.|.| ....:.|...:.|:.|     :| ||..:.||                  ..|.||.|
Human   288 VRLQGNPLGEASPDAPSSPVAAL-----IP-EMPRLFLT------------------SDLDSFPV 328

  Fly   939 DARGGSMRGYRHNGVRIIVPPKACAEPTRITCRYVKPQRVVNPP----PLMEGEALVSRILEMSP 999
            ..:|.|:.  ...|||:..|..|.|.|  ||.||    |::.|.    ||...:||:|.:||:.|
Human   329 TPQGCSVT--LACGVRLQFPAGATATP--ITIRY----RLLLPEPGLVPLGPHDALLSHVLELQP 385

  Fly  1000 VDGMFLSPITLEVPHYGTLRKNEREIIILRSDNGESWREHNLYKDIIGEDINQTEEFHSDRIVRI 1064
            ....|...:.|.:.......:..||::: |:.|..||.:...|   :.|:..|....|.      
Human   386 HGVAFQQDVGLWLLFTPPQARRCREVVV-RTRNDNSWGDLETY---LEEEAPQRLWAHC------ 440

  Fly  1065 VTQNVPHF--FAVVSRVRQEVHVIGPDGGTVFSTAVPQVKAIFPPHALTKKIRVGLQAQSVDLVE 1127
               .||||  |.||||......::.|:|..:.|:..|.||.||||.|..:..||.:|...:...|
Human   441 ---QVPHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRE 502

  Fly  1128 CSKLLGQ-GVAVSPVVTV-EPRRRKFHKAITLSIPAPKACTNSMVNACYGNGNSSSPTLRLLCSI 1190
            ...|||: ..||||::.: :.....|.:.:|:.:|.|...|...::         ...|.||   
Human   503 LQALLGEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSGITGLSLD---------RSRLHLL--- 555

  Fly  1191 SGGQTRATWEDVTG--------------------STPLSFVRD----SVTFTTTVSARFWL-IDC 1230
            ......|||:|:|.                    |.|.||:..    .....|..|.|:|| ...
Human   556 YWAPPAATWDDITAQVVLELTHLYARFQVTHFSWSVPPSFLSPPPPVCTALLTPSSPRYWLWYTT 620

  Fly  1231 RNIIDAGRMATELYSHLAKVPFYVKFVIFAKRISQTEAKFSVFCMTDDKEDKTLEQ-QEYFKEVA 1294
            :|.:  |.:|.:.:..|..  ..|..:...:|....:....  |:..:|.|.||.: .|.::...
Human   621 KNCV--GGLARKAWERLRL--HRVNLIALQRRRDPEQVLLQ--CLPRNKVDATLRRLLERYRGPE 679

  Fly  1295 KSRDIEVLQNQIVYLEFAGNIVPILKKGEQLYTKFQPFCENRLSFSAHIKDQEFPHGRICFMTYP 1359
            .|..:|:.:                  ||:.:..|    |..:...|...|  ...|||||:.|.
Human   680 PSDTVEMFE------------------GEEFFAAF----ERGIDVDADRPD--CVEGRICFVFYS 720

  Fly  1360 MVGPDEVPLKPLCTLNISVDFKTITNHLERDNLHSLNDCINAHGKLNHNENIV-FGVKEQ----- 1418
                   .||     |:...:.|.|  |:|       :.....|:::.....| ..|.|:     
Human   721 -------HLK-----NVKEVYVTTT--LDR-------EAQAVRGQVSFYRGAVPVRVPEEAEAAR 764

  Fly  1419 QVKKIDITKACIMSS-DIKL--------------IHEADVILDD-------------ICSHLGSD 1455
            |.|..|   |..|:: .|||              :..|.:.|.|             :...||.|
Human   765 QRKGAD---ALWMATLPIKLPRLRGSEGPRRGAGLSLAPLNLGDAETGFLTQSNLLSVAGRLGLD 826

  Fly  1456 WPLLANVLGVSQADIDLVKTEFLLNDSVKQSMAMLQLWLEHGGILTGNV--LAEALYKIGRSDIV 1518
            ||.:|..||||..::..::.|| .:|..:|...||..|.|......|.|  |.:||.:..|.|:.
Human   827 WPAVALHLGVSYREVQRIRHEF-RDDLDEQIRHMLFSWAERQAGQPGAVGLLVQALEQSDRQDVA 890

  Fly  1519 EKSFKNAEFGTHQPEKVLPTAGI 1541
            |:.....|.|..:.:..:...|:
Human   891 EEVRAVLELGRRKYQDSIRRMGL 913

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_001162819.1 ANK 67..192 CDD:238125
ANK repeat 72..103 CDD:293786
Ank_2 77..167 CDD:289560
ANK repeat 105..136 CDD:293786
ANK repeat 138..169 CDD:293786
ANK 204..320 CDD:238125
ANK repeat 204..231 CDD:293786
Ank_2 205..295 CDD:289560
ANK repeat 233..264 CDD:293786
ANK repeat 266..295 CDD:293786
ANK 294..419 CDD:238125
ANK repeat 299..330 CDD:293786
Ank_4 300..353 CDD:290365
ANK repeat 332..363 CDD:293786
Ank_2 337..428 CDD:289560
ANK 360..485 CDD:238125
ANK repeat 365..395 CDD:293786
ANK repeat 398..427 CDD:293786
ANK repeat 431..462 CDD:293786
Ank_2 436..526 CDD:289560
ANK repeat 464..494 CDD:293786
ANK 491..616 CDD:238125 12/48 (25%)
ANK repeat 496..527 CDD:293786
Ank_2 501..592 CDD:289560 6/24 (25%)
ANK repeat 529..560 CDD:293786
ANK 557..682 CDD:238125 26/115 (23%)
ANK repeat 562..590 CDD:293786 6/22 (27%)
Ank_5 582..636 CDD:290568 10/53 (19%)
ANK repeat 595..625 CDD:293786 6/29 (21%)
ANK repeat 628..657 CDD:293786 3/28 (11%)
Ank_2 633..723 CDD:289560 20/90 (22%)
ANK repeat 661..691 CDD:293786 9/30 (30%)
ANK 692..812 CDD:238125 23/135 (17%)
ANK repeat 693..724 CDD:293786 8/45 (18%)
Ank_2 698..788 CDD:289560 21/105 (20%)
ANK repeat 726..755 CDD:293786 5/28 (18%)
ANK repeat 759..788 CDD:293786 6/29 (21%)
ZU5 930..1034 CDD:128514 33/107 (31%)
Death_ank 1439..1521 CDD:260029 29/96 (30%)
PIDD1XP_005253062.1 leucine-rich repeat 39..63 CDD:275380 6/20 (30%)
leucine-rich repeat 64..91 CDD:275380 7/35 (20%)
LRR_RI <117..>279 CDD:238064 44/225 (20%)
LRR_8 126..183 CDD:290566 16/75 (21%)
leucine-rich repeat 127..152 CDD:275380 8/42 (19%)
leucine-rich repeat 153..172 CDD:275380 5/19 (26%)
leucine-rich repeat 173..195 CDD:275380 6/23 (26%)
LRR_8 194..252 CDD:290566 14/91 (15%)
leucine-rich repeat 196..218 CDD:275380 3/28 (11%)
leucine-rich repeat 219..241 CDD:275380 5/38 (13%)
LRR_8 240..295 CDD:290566 16/71 (23%)
leucine-rich repeat 242..264 CDD:275380 6/31 (19%)
leucine-rich repeat 265..286 CDD:275380 5/27 (19%)
ZU5 325..398 CDD:295340 28/80 (35%)
Peptidase_S68 421..453 CDD:287439 12/43 (28%)
ZU5 465..537 CDD:295340 23/71 (32%)
Death_PIDD 812..897 CDD:260049 26/85 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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