DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ank and ANKMY1

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_016859764.1	Gene:	ANKMY1 / 51281	HGNCID:	20987	Length:	1131	Species:	Homo sapiens

Alignment Length:	660	Identity:	147/660 - (22%)
Similarity:	251/660 - (38%)	Gaps:	168/660 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 NGFTP----------LYMAAQE-NHDNCCRTLLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVL 191
            :||.|          :.:.|:| ||:..||.|..|.|:..::...|:|.||.|....|:.||.:|
Human   337 SGFAPCGPKEQLSMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLL 401

  Fly   192 LE--NDV-----RGKVRLP---ALHIAAKKNDVNAAKLLL---QHDPNADIVS--KSGFTPLHIA 241
            |:  .||     .|...|.   .||..|:....|.|:..:   |..|...:|.  .|.|...::.
Human   402 LDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLE 466

  Fly   242 AHYGNVDI------------ATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKID 294
            :.|..|::            |.|||           ..::..|....:.....|      |..||
Human   467 SLYYEVNVPSQGSYELRPPPAPLLL-----------PRVSGSHEGGHFQDTGQC------GGSID 514

  Fly   295 --AATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKA 357
              :::..|.:||...| .||||                 :||..:    .|..|..:....:.|.
Human   515 HRSSSLKGDSPLVKGS-LGHVE-----------------SGLEDV----LGNTDRGSLCSAETKF 557

  Fly   358 PVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIAC----KKNRIKMVELL 418
            ..:....|:...|..|......:...||.....:|...:.:..|...:|.    ::.|.:.::||
Human   558 ESNVCVCDFSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLL 622

  Fly   419 IKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIRI 483
            ::.||:..               :.|:.:.:                   |.||.:|...|.:|:
Human   623 LRRGADPN---------------LCCVPMQV-------------------LFLAVKAGDVDGVRL 653

  Fly   484 LLRSAKVDAIAREGQ----TPLHVASRL---GNINIIMLLLQHGAEINAQSNDKYSALHIAAKEG 541
            ||.......|....|    ||||:|:.|   ..:.|:.|||....:::|:::|:....    |.|
Human   654 LLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTY----KPG 714

  Fly   542 QENIVQVLLENGAE----------NNAVTKK-GFTPLHLACKYGKQN-----VVQILLQNGASID 590
            :.:::...|:...|          :.|:.:: |.|.||:||:....|     :|::||.:||:.:
Human   715 KLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGANPN 779

  Fly   591 FQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNG-QCAIHIACKKNY---------LEIA 645
            ...... :||.::....|..:|:.||..|:.|||....| ..|:.:||...|         |.:.
Human   780 LLWSGH-SPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALI 843

  Fly   646 MQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGVISAAAKNGLT--PLH--VAAQEGH 706
            .:|:.||||:       ..|:.|  :.|..:.|...::||.........:.  |.|  :.|:...
Human   844 DRLISHGADI-------LKPVML--RQGEKEAVGTAVDYGYFRFFQDRRIARCPFHTLMPAERET 899

  Fly   707 VLVSQILLEH 716
            .|..:.|||:
Human   900 FLARKRLLEY 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125	20/64 (31%)
		ANK repeat	72..103	CDD:293786
		Ank_2	77..167	CDD:289560	12/39 (31%)
		ANK repeat	105..136	CDD:293786
		ANK repeat	138..169	CDD:293786	12/41 (29%)
		ANK	204..320	CDD:238125	29/134 (22%)
		ANK repeat	204..231	CDD:293786	7/29 (24%)
		Ank_2	205..295	CDD:289560	21/108 (19%)
		ANK repeat	233..264	CDD:293786	8/42 (19%)
		ANK repeat	266..295	CDD:293786	5/30 (17%)
		ANK	294..419	CDD:238125	24/130 (18%)
		ANK repeat	299..330	CDD:293786	8/30 (27%)
		Ank_4	300..353	CDD:290365	12/52 (23%)
		ANK repeat	332..363	CDD:293786	5/30 (17%)
		Ank_2	337..428	CDD:289560	16/94 (17%)
		ANK	360..485	CDD:238125	20/128 (16%)
		ANK repeat	365..395	CDD:293786	6/29 (21%)
		ANK repeat	398..427	CDD:293786	7/32 (22%)
		ANK repeat	431..462	CDD:293786	1/30 (3%)
		Ank_2	436..526	CDD:289560	21/96 (22%)
		ANK repeat	464..494	CDD:293786	8/29 (28%)
		ANK	491..616	CDD:238125	35/147 (24%)
		ANK repeat	496..527	CDD:293786	12/37 (32%)
		Ank_2	501..592	CDD:289560	27/109 (25%)
		ANK repeat	529..560	CDD:293786	6/40 (15%)
		ANK	557..682	CDD:238125	38/140 (27%)
		ANK repeat	562..590	CDD:293786	12/33 (36%)
		Ank_5	582..636	CDD:290568	16/54 (30%)
		ANK repeat	595..625	CDD:293786	9/29 (31%)
		ANK repeat	628..657	CDD:293786	11/38 (29%)
		Ank_2	633..723	CDD:289560	22/97 (23%)
		ANK repeat	661..691	CDD:293786	6/29 (21%)
		ANK	692..812	CDD:238125	7/29 (24%)
		ANK repeat	693..724	CDD:293786	7/28 (25%)
		Ank_2	698..788	CDD:289560	6/21 (29%)
		ANK repeat	726..755	CDD:293786
		ANK repeat	759..788	CDD:293786
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
ANKMY1	XP_016859764.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910