DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank and mask

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001247280.1	Gene:	mask / 50070	FlyBaseID:	FBgn0043884	Length:	4010	Species:	Drosophila melanogaster

Alignment Length:	1016	Identity:	251/1016 - (24%)
Similarity:	399/1016 - (39%)	Gaps:	243/1016 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 NALHLAAKD-GYVDICCELLRRGIKIDNATKKGNTAL------------HIASLAGQHDVINQLI 126
            ||.::.:|| .::......|..|.....|......||            .:.::.|....:|..:
  Fly   266 NAPNMTSKDSAHLKFATTTLLMGAAAAAADSNAGAALGGSGAGGSGSSSSVGAVGGARMALNPAV 330

  Fly   127 -LYNANVNV-QSLNGFTPLYMAAQENHD-------------------NCCRTLLANGANPSLSTE 170
             :.||.|.: |.|........|:..|..                   |...:.|.|...|...|:
  Fly   331 DMANAAVLLKQKLKDAAAAASASASNRSATSSMSSTASSLSSSAGIVNAISSALQNIITPDTDTD 395

  Fly   171 DGFTPLAVA--MQQGHDKIVAVLL---------------ENDV-----RGKVRLPALHIAAKKND 213
            ..|.|..|.  :.:..::.|:.:|               |:|.     .|:||........:..|
  Fly   396 TEFYPQPVTTDLSESEEESVSEILLAFLCLRPDLLDDIPESDPDSCPHEGEVREDEDETEEESED 460

  Fly   214 VNAAK-----------LLLQ-----------HDPNADIVSKSGFTPLHIAAHYGNVDIATLL--- 253
            .:.::           .:||           .|...|....|.|  |..|.:..:.:|:.||
  Fly   461 SDESEGEEEEEDEEEIDVLQDNDADDEEIDDEDEEEDAPEVSSF--LLDANNKRSSNISALLEAA 523

  Fly   254 LNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCA---------SR 309
            .|.||.|...|.|.|.                          .|:..||.:.||         ||
  Fly   524 ANEKAPVLRHATHAID--------------------------ETKQALTKMRCASSPRDKNGFSR 562

  Fly   310 S-------GHVEVIKHLLQQNAPIL----TKTKNGLSALHMAAQGEHDEAAHLLLD-NKAPVDEV 362
            |       ..|..:|.||.:....|    ..|.:|.|.|.||....:.|.|.:||. :.|.|::.
  Fly   563 SLVAACTDNDVNTVKRLLCKGNVNLNDAAASTDDGESLLSMACSAGYYELAQVLLAMSAAQVEDK 627

  Fly   363 TVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGA 427
            .....|.|..||..||:.:.||||::.|:.||....|.|||..||...::.:|::|:|||||:..
  Fly   628 GQKDSTPLMEAASAGHLDIVKLLLNHNADVNAHCATGNTPLMFACAGGQVDVVKVLLKHGANVEE 692

  Fly   428 TTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIR-GETPLHLAARANQADIIRILLRSA--- 488
            ..|:|.|||..|:..|.:.:...||:|.|..:..:.. .|:.|.||......|::|.||::.
  Fly   693 QNENGHTPLMEAASAGHVEVAKVLLEHGAGINTHSNEFKESALTLACYKGHLDMVRFLLQAGADQ 757

  Fly   489 --KVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLE 551
              |.|    |..|.|..||..|::.:..|||..||::|..::...|.|.:||..|...:..:|:|
  Fly   758 EHKTD----EMHTALMEASMDGHVEVARLLLDSGAQVNMPTDSFESPLTLAACGGHVELATLLIE 818

  Fly   552 NGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLL 616
            .||....|..:|:|||..|.:.|.:.:|.:||..||:|:            ||
  Fly   819 RGANIEEVNDEGYTPLMEAAREGHEEMVALLLSKGANIN------------AT------------ 859

  Fly   617 KNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLL 681
                    .....:.|:.:||...::|:|..|::.||::.:   ...:||..|:|.|:.|:|..|
  Fly   860 --------TEETQETALTLACCGGFMEVAAFLIKEGANLEL---GASTPLMEASQEGHTDLVSFL 913

  Fly   682 LEYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKF 745
            |:... :.|..:.|.|.|..|.:.||...:.:||.:||.:...:..|.|||..|...|||..|||
  Fly   914 LKKKANVHAETQTGDTALTHACENGHTDAAGVLLSYGAELEHESEGGRTPLMKACRAGHLCTVKF 978

  Fly   746 FIENDADI--EMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLGYVTV 808
            .|:..|::  :.:|| .:|.|..|...||..::.|||::.|:|....||.:|.|..||..|:..|
  Fly   979 LIQKGANVNKQTTSN-DHTALSLACAGGHQSVVELLLKNNADPFHKLKDNSTMLIEASKGGHTRV 1042

  Fly   809 MESL----KIVTSTSVINSNI----------GAIEEKLKVMTPELM------------------- 840
            :|.|    .|..:.:..::|:          |..:.:.|:|..:|.
  Fly  1043 VELLFRYPNISPTENAASANVTQAAPTSNQPGPNQMRQKIMKQQLQHQLQQLNAPPGLHELSEAA 1107

  Fly   841 ---------QETLLSDSDDES------CDDLLDHNHYKYMATDDLKANYGQDQKNFDTTNTDHDL 890
                     |:...|..:..|      ..|.||....:..||..:.|..|.     .||.::..:
  Fly  1108 RASNQQHFHQQQFSSAGNGSSNIVAMGTGDFLDAGELQLTATAGMSAGAGT-----STTGSETGM 1167

  Fly   891 TDVSVLNKKEILPNEMSCIELTEIGHKPDNVVIARSQV-HL 930
            .:.          .|:..|:||.:|.:....:||:|:: ||
  Fly  1168 EEY----------GEVGGIDLTTLGAQQQEGLIAKSRLFHL 1198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125	27/152 (18%)
		ANK repeat	72..103	CDD:293786	6/28 (21%)
		Ank_2	77..167	CDD:289560	20/123 (16%)
		ANK repeat	105..136	CDD:293786	7/44 (16%)
		ANK repeat	138..169	CDD:293786	6/49 (12%)
		ANK	204..320	CDD:238125	29/156 (19%)
		ANK repeat	204..231	CDD:293786	5/48 (10%)
		Ank_2	205..295	CDD:289560	19/114 (17%)
		ANK repeat	233..264	CDD:293786	11/33 (33%)
		ANK repeat	266..295	CDD:293786	2/28 (7%)
		ANK	294..419	CDD:238125	45/145 (31%)
		ANK repeat	299..330	CDD:293786	12/50 (24%)
		Ank_4	300..353	CDD:290365	20/72 (28%)
		ANK repeat	332..363	CDD:293786	11/31 (35%)
		Ank_2	337..428	CDD:289560	35/91 (38%)
		ANK	360..485	CDD:238125	43/125 (34%)
		ANK repeat	365..395	CDD:293786	12/29 (41%)
		ANK repeat	398..427	CDD:293786	13/28 (46%)
		ANK repeat	431..462	CDD:293786	10/30 (33%)
		Ank_2	436..526	CDD:289560	29/95 (31%)
		ANK repeat	464..494	CDD:293786	10/35 (29%)
		ANK	491..616	CDD:238125	37/124 (30%)
		ANK repeat	496..527	CDD:293786	12/30 (40%)
		Ank_2	501..592	CDD:289560	32/90 (36%)
		ANK repeat	529..560	CDD:293786	9/30 (30%)
		ANK	557..682	CDD:238125	30/124 (24%)
		ANK repeat	562..590	CDD:293786	11/27 (41%)
		Ank_5	582..636	CDD:290568	8/53 (15%)
		ANK repeat	595..625	CDD:293786	2/29 (7%)
		ANK repeat	628..657	CDD:293786	8/28 (29%)
		Ank_2	633..723	CDD:289560	27/90 (30%)
		ANK repeat	661..691	CDD:293786	10/30 (33%)
		ANK	692..812	CDD:238125	44/121 (36%)
		ANK repeat	693..724	CDD:293786	10/30 (33%)
		Ank_2	698..788	CDD:289560	33/91 (36%)
		ANK repeat	726..755	CDD:293786	13/30 (43%)
		ANK repeat	759..788	CDD:293786	10/28 (36%)
		ZU5	930..1034	CDD:128514	1/1 (100%)
		Death_ank	1439..1521	CDD:260029
mask	NP_001247280.1	ANK	555..684	CDD:238125	40/128 (31%)
		Ank_2	564..659	CDD:289560	28/94 (30%)
		ANK repeat	596..628	CDD:293786	11/31 (35%)
		ANK	633..751	CDD:238125	43/117 (37%)
		ANK repeat	633..661	CDD:293786	13/27 (48%)
		Ank_2	635..724	CDD:289560	36/88 (41%)
		ANK repeat	663..694	CDD:293786	13/30 (43%)
		ANK repeat	696..724	CDD:293786	10/27 (37%)
		Ank_5	716..771	CDD:290568	17/58 (29%)
		ANK	726..850	CDD:238125	39/127 (31%)
		ANK repeat	730..760	CDD:293786	8/29 (28%)
		ANK repeat	765..794	CDD:293786	11/28 (39%)
		Ank_2	768..859	CDD:289560	32/102 (31%)
		ANK repeat	796..827	CDD:293786	9/30 (30%)
		ANK repeat	829..858	CDD:293786	12/40 (30%)
		ANK repeat	862..894	CDD:293786	8/34 (24%)
		ANK	896..1014	CDD:238125	41/118 (35%)
		ANK repeat	896..923	CDD:293786	9/26 (35%)
		Ank_2	898..989	CDD:289560	32/90 (36%)
		ANK repeat	927..957	CDD:293786	10/29 (34%)
		ANK repeat	959..991	CDD:293786	13/31 (42%)
		ANK	989..>1049	CDD:238125	22/60 (37%)
		ANK repeat	993..1023	CDD:293786	11/30 (37%)
		Ank_4	995..1046	CDD:290365	19/50 (38%)
		ANK	2321..2349	CDD:197603
		ANK repeat	2323..2352	CDD:293786
		Ank_2	2326..2419	CDD:289560
		ANK	2350..2477	CDD:238125
		ANK repeat	2354..2386	CDD:293786
		ANK repeat	2390..2419	CDD:293786
		Ank_2	2393..2486	CDD:289560
		ANK repeat	2421..2452	CDD:293786
		ANK repeat	2456..2486	CDD:293786
		ANK	2457..2579	CDD:238125
		Ank_2	2461..2552	CDD:289560
		ANK repeat	2492..2521	CDD:293786
		ANK	2519..2645	CDD:238125
		ANK repeat	2523..2589	CDD:293786
		Ank_2	2528..2622	CDD:289560
		ANK repeat	2560..2587	CDD:293786
		ANK repeat	2591..2622	CDD:293786
		KH-I	3049..3110	CDD:238053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3248
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910