DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank and Tnks

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster

Alignment Length:	1351	Identity:	342/1351 - (25%)
Similarity:	548/1351 - (40%)	Gaps:	301/1351 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SETCAINGMALDNKNGIIKQNDATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNA--LH 78
            |.:.||..:.||    .:..||.......|.::|:|.||...:   ....:|:.:..|..:  ||
  Fly     5 SRSRAILSVNLD----AVMANDPLRELFEACKTGEIAKVKKLI---TPQTVNARDTAGRKSTPLH 62

  Fly    79 LAAKDGYVDICCELLRRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPL 143
            .||..|..::...||..|..|....:.|...||.....|..:|:..|:...|:.|......:|||
  Fly    63 FAAGYGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPL 127

  Fly   144 YMAAQENHDNCCRTLLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIA 208
            :.||.:...:.|..||.:|||.::...:..|||.:|     |:....:|..:.|....|.|....
  Fly   128 HEAASKGKVDVCLALLQHGANHTIRNSEQKTPLELA-----DEATRPVLTGEYRKDELLEAARSG 187

  Fly   209 AKKNDVNAAKLLLQHDP-NADIVSKSG--FTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITP 270
            |:.      :||....| |.:..:..|  .||||:||.|..:.|..:||.|.|||:...|..:.|
  Fly   188 AED------RLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVP 246

  Fly   271 LHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLS 335
            ||.||.:|...:..||:..||.::|......||||.|:....|||...||.:.|.......:..|
  Fly   247 LHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKS 311

  Fly   336 ALHMAAQGEHDE------AAHLLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNA 394
            |:..|...|..|      ..|.|||.....|                  |..||.|:..:.....
  Fly   312 AIDAAPTRELRERIAFEYKGHCLLDACRKCD------------------VSRAKKLVCAEIVNFV 358

  Fly   395 RALNGFTPLHIACKK---NRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEA 456
            ....|.||||:|...   .|.:::|||.:.|:.:....::.|||||:|:.:...:.:..||:..|
  Fly   359 HPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGA 423

  Fly   457 SADLPTIRGETPLHLAARANQADIIRILLR-SAKVDAIAREGQTPLHVAS--------------- 505
            ..:.....|:||||..||..||  :|:||. :|..:.::.||.|...:||
  Fly   424 KVNALDSLGQTPLHRCARDEQA--VRLLLSYAADTNIVSLEGLTAAQLASDSVLKLLKNPPDSET 486

  Fly   506 ------RLGNINII-MLLLQHGAEINAQSND-KYSA-LHIAAKEGQENIVQVLLENGAENNAVTK 561
                  :.|:::.: .::|.:...:|.:..| ::|. ||.||...:..:||.|||:|||..|..|
  Fly   487 HLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEVYAADK 551

  Fly   562 KGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCA 626
            .|..|||.||.||...|.::|:::||:::.......||||.|.......|.:||||:|:.|....
  Fly   552 GGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKKN 616

  Fly   627 RNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGVIS--- 688
            |:|.....:. |::..::| :||:           |.|.|..||:.||:..||.|:....|:
  Fly   617 RDGATPADLV-KESDHDVA-ELLR-----------GPSALLDAAKKGNLARVQRLVTPESINCRD 668

  Fly   689 AAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDADI 753
            |..:|. ||||:||...:...::.|||:||:::.:.:.|..|||.|:.|||||:....|::...:
  Fly   669 AQGRNS-TPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVV 732

  Fly   754 EMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHI--------------ASNLG 804
            ..:...|:||||:|||:|...:.:|||.|.|:.....::|.|.:.:              |::|.
  Fly   733 NATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELATADDVKCLLQDAMATSLS 797

  Fly   805 YVTVMESLKIVTSTS------------VINSNIGAIEEK--------------LKVMTP-ELMQE 842
            ...:..|.:.:||:|            ..:|:..||...              |.|..| .|...
  Fly   798 QQALSASTQSLTSSSPAPDATAAAAPGTSSSSSSAILSPTTETVLLPTGASMILSVPVPLPLSSS 862

  Fly   843 TLLS--------DSDDESCDDLLDHNHYKYMATDDLKANYGQDQKNFDT-TNTDHDLTDVSVLNK 898
            |.:|        .::..|.||||                     .:.|| ||....|:...:.:.
  Fly   863 TRISPAQGAEANGAEGSSSDDLL---------------------PDADTITNVSGFLSSQQLHHL 906

  Fly   899 KEILPNEMSCIE-LTEIGHKPDNVVIARSQVHLGFLVSFLVDARGGSMRGYRHNGVRIIVPPKAC 962
            .|:...|...:: |.|:||  |::    .||             |.|..|:||   :|:   |..
  Fly   907 IELFEREQITLDILAEMGH--DDL----KQV-------------GVSAYGFRH---KIL---KGI 946

  Fly   963 AEPTRITCRYVKPQRVVNPPPLMEGEALVSRILEMSPVDGMFLSPITLEVPHYGTLRKNEREIII 1027
            |:....|             .:.....|.:.::::.|.|..|   :.:|.....|:|::.
  Fly   947 AQLRSTT-------------GIGNNVNLCTLLVDLLPDDKEF---VAVEEEMQATIREHR----- 990

  Fly  1028 LRSDNGES--------------------WREH-NLYKDIIGEDINQTEE---FHSDRIVRIVTQ- 1067
               |||::                    |..: :..::|..|:..|:.|   ||....:..:.|
  Fly   991 ---DNGQAGGYFTRYNIIRVQKVQNRKLWERYAHRRQEIAEENFLQSNERMLFHGSPFINAIVQR 1052

  Fly  1068 --NVPH-----------FFAV-VSRVRQEVHVIGPDGGTVFSTAVPQVKAIFPPHALTKKIRVG- 1117
              :..|           :||. .|:..|.|:.||  ||....:...:...:.|...|..::.:|
  Fly  1053 GFDERHAYIGGMFGAGIYFAEHSSKSNQYVYGIG--GGIGCPSHKDKSCYVCPRQLLLCRVALGK 1115

  Fly  1118 --LQAQSVDLVEC----SKLLGQ----GVAVSPVVTVEPRRRKFHKAITLSIPAPKACTNSMVNA 1172
              ||..::.:...    ..::|:    |:..:..|.....:......||..|..|
  Fly  1116 SFLQYSAMKMAHAPPGHHSVVGRPSAGGLHFAEYVVYRGEQSYPEYLITYQIVKP---------- 1170

  Fly  1173 CYGNGNSSSPTLRLLCSISGGQTRATWEDVTGSTPLSFVRDSVTFTTTVSA 1223
                 :.||         ||.:... |....||||          |||..|
  Fly  1171 -----DDSS---------SGTEDTRXWMPSVGSTP----------TTTSPA 1197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125	35/126 (28%)
		ANK repeat	72..103	CDD:293786	10/32 (31%)
		Ank_2	77..167	CDD:289560	28/89 (31%)
		ANK repeat	105..136	CDD:293786	8/30 (27%)
		ANK repeat	138..169	CDD:293786	11/30 (37%)
		ANK	204..320	CDD:238125	41/118 (35%)
		ANK repeat	204..231	CDD:293786	6/27 (22%)
		Ank_2	205..295	CDD:289560	31/92 (34%)
		ANK repeat	233..264	CDD:293786	15/32 (47%)
		ANK repeat	266..295	CDD:293786	10/28 (36%)
		ANK	294..419	CDD:238125	35/133 (26%)
		ANK repeat	299..330	CDD:293786	11/30 (37%)
		Ank_4	300..353	CDD:290365	17/58 (29%)
		ANK repeat	332..363	CDD:293786	10/36 (28%)
		Ank_2	337..428	CDD:289560	23/99 (23%)
		ANK	360..485	CDD:238125	35/127 (28%)
		ANK repeat	365..395	CDD:293786	4/29 (14%)
		ANK repeat	398..427	CDD:293786	11/31 (35%)
		ANK repeat	431..462	CDD:293786	9/30 (30%)
		Ank_2	436..526	CDD:289560	27/112 (24%)
		ANK repeat	464..494	CDD:293786	13/30 (43%)
		ANK	491..616	CDD:238125	43/148 (29%)
		ANK repeat	496..527	CDD:293786	8/52 (15%)
		Ank_2	501..592	CDD:289560	33/114 (29%)
		ANK repeat	529..560	CDD:293786	15/32 (47%)
		ANK	557..682	CDD:238125	41/124 (33%)
		ANK repeat	562..590	CDD:293786	12/27 (44%)
		Ank_5	582..636	CDD:290568	17/53 (32%)
		ANK repeat	595..625	CDD:293786	12/29 (41%)
		ANK repeat	628..657	CDD:293786	5/28 (18%)
		Ank_2	633..723	CDD:289560	28/92 (30%)
		ANK repeat	661..691	CDD:293786	12/32 (38%)
		ANK	692..812	CDD:238125	41/133 (31%)
		ANK repeat	693..724	CDD:293786	12/30 (40%)
		Ank_2	698..788	CDD:289560	34/89 (38%)
		ANK repeat	726..755	CDD:293786	11/28 (39%)
		ANK repeat	759..788	CDD:293786	14/28 (50%)
		ZU5	930..1034	CDD:128514	18/103 (17%)
		Death_ank	1439..1521	CDD:260029
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	33/113 (29%)
		ANK repeat	59..87	CDD:293786	9/27 (33%)
		Ank_2	61..153	CDD:289560	28/91 (31%)
		ANK repeat	89..120	CDD:293786	8/30 (27%)
		ANK repeat	122..153	CDD:293786	11/30 (37%)
		ANK	202..316	CDD:238125	40/113 (35%)
		ANK repeat	212..240	CDD:293786	14/27 (52%)
		Ank_2	214..306	CDD:289560	35/91 (38%)
		ANK repeat	242..273	CDD:293786	11/30 (37%)
		ANK repeat	275..306	CDD:293786	11/30 (37%)
		ANK	361..478	CDD:238125	38/118 (32%)
		ANK repeat	363..396	CDD:293786	11/32 (34%)
		Ank_2	367..459	CDD:289560	30/93 (32%)
		ANK	393..573	CDD:238125	55/181 (30%)
		ANK repeat	398..429	CDD:293786	9/30 (30%)
		ANK repeat	431..459	CDD:293786	13/29 (45%)
		ANK repeat	483..515	CDD:293786	3/31 (10%)
		Ank_4	486..540	CDD:290365	11/53 (21%)
		ANK	512..637	CDD:238125	45/126 (36%)
		ANK repeat	522..550	CDD:293786	13/27 (48%)
		Ank_2	524..616	CDD:289560	38/91 (42%)
		ANK repeat	552..583	CDD:293786	12/30 (40%)
		ANK repeat	585..610	CDD:293786	10/24 (42%)
		ANK repeat	638..668	CDD:293786	11/40 (28%)
		Ank_4	641..693	CDD:290365	18/52 (35%)
		ANK	665..779	CDD:238125	40/114 (35%)
		ANK repeat	672..703	CDD:293786	12/31 (39%)
		Ank_2	677..769	CDD:289560	34/91 (37%)
		ANK repeat	705..736	CDD:293786	11/30 (37%)
		ANK repeat	738..769	CDD:293786	14/30 (47%)
		SAM_tankyrase1,2	887..952	CDD:188923	22/89 (25%)
		SAM	890..952	CDD:197735	21/86 (24%)
		tankyrase_like	948..1170	CDD:238718	40/247 (16%)
		PARP	961..1165	CDD:279038	37/216 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3248
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.810