DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank and Ank2

DIOPT Version :10

Sequence 1:NP_787122.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster


Alignment Length:1552 Identity:871/1552 - (56%)
Similarity:1114/1552 - (71%) Gaps:119/1552 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 KNGIIKQNDATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVDICCELL 93
            :||  .|.|...|||||||:|::::|::.|.  ...|||:.|||||||||||:|||::.:..|||
  Fly     4 ENG--AQGDGNTSFLRAARAGNLERVLEHLK--NNIDINTSNANGLNALHLASKDGHIHVVSELL 64

  Fly    94 RRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPLYMAAQENHDNCCRTL 158
            |||..:|:|||||||||||||||||.:|:..|:.:||:|||||.|||||||||||||||...|.|
  Fly    65 RRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLL 129

  Fly   159 LANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAKLLLQH 223
            |:||||.||:||||||||||||||||||:||||||:|.|||||||||||||||:||.||.|||.:
  Fly   130 LSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDN 194

  Fly   224 DPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLC 288
            |.|.|:.|||||||||||:||||.:||.||:...|||||.|||||:|||||.||||.::.:|||.
  Fly   195 DHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLE 259

  Fly   289 RGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLL 353
            :|..|:|.|||||||||||:||||.:|:..||::.|||..||||||:.|||||||||.:||.:||
  Fly   260 KGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILL 324

  Fly   354 DNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELL 418
            .::|||||||||||||||||||||||:|||||||..|:.|||||||||||||||||||:|:||||
  Fly   325 YHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELL 389

  Fly   419 IKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIRI 483
            ::|||:|.|||||||||||||:||||:|||||||||:||.|:||:||||||||||||||.|||||
  Fly   390 LRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRI 454

  Fly   484 LLRS-AKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQ 547
            |||: |:|||.|||.|||||:||||||::|:||||||||:::|.:.|.|:||||||||||:.:..
  Fly   455 LLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAA 519

  Fly   548 VLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIV 612
            ||:||||..:|.||||||||||..|||...|.|:|||..|.:|.||||.|||||||.||||..:.
  Fly   520 VLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVA 584

  Fly   613 ELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDM 677
            .|||:.|:||:..|:||...:|||.:||.::||..||::||..|..||:||:||||::|.|:.::
  Fly   585 LLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEI 649

  Fly   678 VQLLLEY-GVISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLD 741
            ..||:|: ..::..|||||||:|:.|||.:|.|::||.::||||...|:.||||||:|:|:|..:
  Fly   650 SNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQAN 714

  Fly   742 LVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLGYV 806
            :|:|.::|.|:::.:::||||||||.|||||..|:||||.||||.||.|.:|.|.||||..|||:
  Fly   715 MVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLGYI 779

  Fly   807 TVMESLKIVTSTSVINSNIGAIEEKLKVMTPELMQETLLSDSDDESCDD-LLDHNHYKYMATDDL 870
            :|::|||.:|......:.....|||.:|:.||.|.|:.:|||::|..:| :|....|:|:..|::
  Fly   780 SVLDSLKTITKEDETAAAPSQAEEKYRVVAPEAMHESFMSDSEEEGGEDNMLSDQPYRYLTVDEM 844

  Fly   871 KANYGQDQKNFDTTNTD----HDLTDVS--------VLNKKEILPNEMSCIELTEI-GHKP---- 918
            | :.|.|....|.|..:    :.:|..:        .:.::.|.|::      |:: |..|    
  Fly   845 K-SLGDDSLPIDVTRDERMDSNRMTQSAEYASGVPPTIGEEVISPHK------TQVYGSSPKATV 902

  Fly   919 DNVVIARSQ-----VHLG-------FLVSFLVDARGGSMRGYRHNGVRIIVPPKACAEPTRITCR 971
            |.|.||...     .|:|       ||||||||||||:|||.||:|||:|:|.::..:|||:|||
  Fly   903 DGVYIANGSGHDEPPHVGRKLSWKSFLVSFLVDARGGAMRGCRHSGVRMIIPSRSTCQPTRVTCR 967

  Fly   972 YVKPQRVVNPPPLMEGEALVSRILEMSPVDGMFLSPITLEVPHYGTLRKNEREIIILRSDNGESW 1036
            ||||||.::||.|||||||.||:||:.|....|:.|:.:||||:.:||..|||||||||||||:|
  Fly   968 YVKPQRTMHPPQLMEGEALASRVLELGPCSTKFIGPVVMEVPHFASLRGKEREIIILRSDNGETW 1032

  Fly  1037 REH------NLYKDII-----GEDINQTEEFHSDRIVRIVTQNVPHFFAVVSRVRQEVHVIGPDG 1090
            |||      .:..|::     .|:|.|.||...:.:.|.||.:.|.:||||||:|||||.|||:|
  Fly  1033 REHTIDNSEEIIHDVLQQCFEPEEIAQLEEQAGNHVCRFVTYDFPQYFAVVSRIRQEVHAIGPEG 1097

  Fly  1091 GTVFSTAVPQVKAIFPPHALTKKIRVGLQAQSVDLVECSKLLGQGVAVSPVVTVEPRRRKFHKAI 1155
            |.|.||.||||:|:||..||||||:||||||.||....:||||:||||||:||||||||||||||
  Fly  1098 GMVSSTVVPQVQAVFPQGALTKKIKVGLQAQPVDPDLTAKLLGRGVAVSPIVTVEPRRRKFHKAI 1162

  Fly  1156 TLSIPAPKACTNSMVNACYGNGNSSSPTLRLLCSISGGQTRATWEDVTGSTPLSFVRDSVTFTTT 1220
            |||:|||||.:..|:|...||    :|||||||||:||.:||.||||||||||:||.|.|:||||
  Fly  1163 TLSMPAPKAHSQGMINQYSGN----TPTLRLLCSITGGPSRAQWEDVTGSTPLTFVNDCVSFTTT 1223

  Fly  1221 VSARFWLIDCRNIIDAGRMATELYSHLAKVPFYVKFVIFAKRISQTEAKFSVFCMTDDKEDKTLE 1285
            |||||||:|||||.||.:||||||..:..|||..|||:|||::...|||..|||||||:||||||
  Fly  1224 VSARFWLMDCRNISDATKMATELYKEVIHVPFIAKFVVFAKKVEPFEAKLRVFCMTDDREDKTLE 1288

  Fly  1286 QQEYFKEVAKSRDIEVLQNQIVYLEFAGNIVPILKKGEQLYTKFQPFCENRLSFSAHIKDQEFPH 1350
            :.|.:.|||||||:|||:.:..|:|.|||:||:.|.|:||..:|:.|.||||.|:..:|||   |
  Fly  1289 KHELYTEVAKSRDVEVLEGKPQYIEMAGNLVPVTKSGDQLQVQFKAFRENRLPFTVRVKDQ---H 1350

  Fly  1351 ----GRICFMTYPMVGPDEVPLKPLCTLNI----------SVDFKTITNHLERDNLHSLNDCINA 1401
                ||..||..|.|...|.|.:|:|.|||          :..|........|.::.||:...|.
  Fly  1351 ADIVGRTLFMKEPKVAKGEPPQQPICILNIVLPEAVIPDSTTAFSDRVTSAYRTSMFSLSKHQND 1415

  Fly  1402 HGKLNHNENIVFGVKEQQVKKIDITKACIMSSDIKLIHEADVILDDICSHLGSDWPLLANVLGVS 1466
            |                            ...||:::        |:.:.||.||..||..:|::
  Fly  1416 H----------------------------YIGDIRIV--------DLSNLLGKDWIQLAPEIGIN 1444

  Fly  1467 QADIDLVKTEFLLNDSV-KQSMAMLQLWLE--HGGILTGNVLAEALYKIGRSDIVEK 1520
            ..:||.:..:  ..||: :|:.:|::|:.:  :..||:   |..||..|||.||::|
  Fly  1445 GEEIDEIINQ--NTDSIARQAQSMIRLYKDKPNYDILS---LETALKNIGRDDIMKK 1496

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_787122.1 ANKYR 20..337 CDD:440430 209/307 (68%)
ANK repeat 72..103 CDD:293786 19/30 (63%)
ANK repeat 105..136 CDD:293786 21/30 (70%)
ANK repeat 138..169 CDD:293786 24/30 (80%)
ANK repeat 204..231 CDD:293786 18/26 (69%)
ANKYR 217..502 CDD:440430 213/285 (75%)
ANK repeat 233..264 CDD:293786 22/30 (73%)
ANK repeat 266..295 CDD:293786 17/28 (61%)
ANK repeat 299..330 CDD:293786 19/30 (63%)
ANK repeat 332..363 CDD:293786 21/30 (70%)
ANK repeat 365..395 CDD:293786 24/29 (83%)
ANK repeat 398..427 CDD:293786 23/28 (82%)
ANK repeat 431..462 CDD:293786 25/30 (83%)
ANK repeat 464..494 CDD:293786 26/30 (87%)
ANK repeat 496..527 CDD:293786 22/30 (73%)
ANKYR 510..797 CDD:440430 158/287 (55%)
ANK repeat 529..560 CDD:293786 19/30 (63%)
ANK repeat 562..590 CDD:293786 17/27 (63%)
ANK repeat 595..625 CDD:293786 18/29 (62%)
ANK repeat 628..657 CDD:293786 13/28 (46%)
ANK repeat 661..691 CDD:293786 11/30 (37%)
ANK repeat 693..724 CDD:293786 17/30 (57%)
ANK repeat 726..755 CDD:293786 13/28 (46%)
ANK repeat 759..788 CDD:293786 22/28 (79%)
ZU5 930..1034 CDD:128514 68/110 (62%)
UPA_2 1250..1378 CDD:375346 71/141 (50%)
Death_ank 1439..1521 CDD:260029 26/85 (31%)
Ank2NP_001189070.1 ANKYR 10..308 CDD:440430 206/299 (69%)
ANK repeat 10..41 CDD:293786 14/32 (44%)
ANK repeat 43..74 CDD:293786 19/30 (63%)
ANK repeat 76..107 CDD:293786 21/30 (70%)
ANK repeat 109..134 CDD:293786 19/24 (79%)
ANK repeat 175..202 CDD:293786 18/26 (69%)
ANKYR 190..473 CDD:440430 211/282 (75%)
ANK repeat 204..235 CDD:293786 22/30 (73%)
ANK repeat 237..268 CDD:293786 18/30 (60%)
ANK repeat 270..300 CDD:293786 19/29 (66%)
ANK repeat 303..367 CDD:293786 49/63 (78%)
ANK repeat 369..400 CDD:293786 24/30 (80%)
ANKYR 383..671 CDD:440430 184/287 (64%)
ANK repeat 402..433 CDD:293786 25/30 (83%)
ANK repeat 435..466 CDD:293786 26/30 (87%)
ANK repeat 468..497 CDD:293786 21/28 (75%)
ANK repeat 501..530 CDD:293786 18/28 (64%)
ANK repeat 535..565 CDD:293786 17/29 (59%)
ANK repeat 567..598 CDD:293786 18/30 (60%)
PHA03100 599..>773 CDD:476869 89/173 (51%)
ANK repeat 600..630 CDD:293786 14/29 (48%)
ANK repeat 633..662 CDD:293786 11/28 (39%)
ANK repeat 666..697 CDD:293786 17/30 (57%)
ANK repeat 699..730 CDD:293786 13/30 (43%)
ANK repeat 732..762 CDD:293786 23/29 (79%)
ZU5 930..1027 CDD:459941 62/96 (65%)
UPA_2 1253..1384 CDD:375346 71/133 (53%)
Death_ank 1417..1497 CDD:260029 28/93 (30%)
PTZ00121 <1443..2235 CDD:173412 18/59 (31%)
PTZ00449 <3292..3611 CDD:185628
PTZ00449 <4400..4857 CDD:185628
PTZ00449 <4908..5267 CDD:185628
PTZ00108 <5179..5374 CDD:240271
PTZ00108 <6034..6230 CDD:240271
PTZ00449 <6620..6979 CDD:185628
PTZ00108 <7119..7314 CDD:240271
PTZ00108 <7347..7544 CDD:240271
PTZ00108 <7651..7848 CDD:240271
PTZ00449 <7804..8119 CDD:185628
PTZ00108 <8183..8381 CDD:240271
PTZ00449 <8430..8745 CDD:185628
PTZ00449 <8784..9125 CDD:185628
PTZ00449 <9028..9353 CDD:185628
PHA03307 9225..>9575 CDD:223039
PHA03307 9903..>10259 CDD:223039
PTZ00108 <10177..10451 CDD:240271
Blue background indicates that the domain is not in the aligned region.

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