DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ank and Asb3

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_038948182.1	Gene:	Asb3 / 364227	RGDID:	1308462	Length:	536	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	116/434 - (26%)
Similarity:	194/434 - (44%)	Gaps:	90/434 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 IATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHV 313
            ::||:  .|.|.........:.:.:|.:.|.:.:...||.:|..:|.|...|..|:|.|:....|
  Rat     5 VSTLI--KKMDFTEAYSDTCSTVGLAAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAV 67

  Fly   314 EVIKHLLQQNAP---ILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAPVDEVTVDYLTALHVAAH 375
            |.::.|:..::.   |.|||..|..|||:|...
  Rat    68 ECLQMLIHTDSSENYIKTKTFEGFCALHLAVSQ-------------------------------- 100

  Fly   376 CGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANI-GATTESGLTPLHVA 439
             ||.||.::||:..|:||...|...|||.:|.:..:|.:::||::||||: |:.:..|...||.|
  Rat   101 -GHWKVTQILLEAGADPNTTTLEETTPLFLAVESGQIDVLKLLLQHGANVNGSHSMCGWNSLHQA 164

  Fly   440 SFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIRILLRSAKVDAIARE--GQTPLH 502
            ||.|                                 .|:.|::||:.. .|...::  |.|||.
  Rat   165 SFQG---------------------------------NAEAIKLLLKQG-ADRECQDDFGITPLF 195

  Fly   503 VASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTKKG--FT 565
            ||::.|.:..:.:|:..||.:|.|:.||.:.|.|||:||....|::||.|||:.:....:.  ..
  Rat   196 VAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSNGADPDLYCNEDNWQL 260

  Fly   566 PLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPN--LCARN 628
            |:|.|.:.|.:..:.:|:.........|.:.|:|::.|........:|.||:||.||:  :|...
  Rat   261 PIHAAAQMGHRKTLDLLIPLTNRACDSGPDKVSPVYSAVFGGREECLETLLQNGYSPDAQMCLVF 325

  Fly   629 G-QCAIHIACKKN--YLEIAMQLLQHGADVNIISKSGFSPLHLA 669
            | ...:.:|.:|:  :..:...||::||.:|        .||||
  Rat   326 GFSSPLCMALQKDCEFSGVVNILLKYGAQLN--------ELHLA 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125
		ANK repeat	72..103	CDD:293786
		Ank_2	77..167	CDD:289560
		ANK repeat	105..136	CDD:293786
		ANK repeat	138..169	CDD:293786
		ANK	204..320	CDD:238125	17/70 (24%)
		ANK repeat	204..231	CDD:293786
		Ank_2	205..295	CDD:289560	9/45 (20%)
		ANK repeat	233..264	CDD:293786	4/14 (29%)
		ANK repeat	266..295	CDD:293786	5/28 (18%)
		ANK	294..419	CDD:238125	34/127 (27%)
		ANK repeat	299..330	CDD:293786	9/33 (27%)
		Ank_4	300..353	CDD:290365	16/55 (29%)
		ANK repeat	332..363	CDD:293786	5/30 (17%)
		Ank_2	337..428	CDD:289560	25/91 (27%)
		ANK	360..485	CDD:238125	31/125 (25%)
		ANK repeat	365..395	CDD:293786	9/29 (31%)
		ANK repeat	398..427	CDD:293786	11/29 (38%)
		ANK repeat	431..462	CDD:293786	7/30 (23%)
		Ank_2	436..526	CDD:289560	22/91 (24%)
		ANK repeat	464..494	CDD:293786	5/29 (17%)
		ANK	491..616	CDD:238125	37/128 (29%)
		ANK repeat	496..527	CDD:293786	11/32 (34%)
		Ank_2	501..592	CDD:289560	28/92 (30%)
		ANK repeat	529..560	CDD:293786	14/30 (47%)
		ANK	557..682	CDD:238125	29/120 (24%)
		ANK repeat	562..590	CDD:293786	5/29 (17%)
		Ank_5	582..636	CDD:290568	14/56 (25%)
		ANK repeat	595..625	CDD:293786	10/31 (32%)
		ANK repeat	628..657	CDD:293786	7/31 (23%)
		Ank_2	633..723	CDD:289560	11/39 (28%)
		ANK repeat	661..691	CDD:293786	4/9 (44%)
		ANK	692..812	CDD:238125
		ANK repeat	693..724	CDD:293786
		Ank_2	698..788	CDD:289560
		ANK repeat	726..755	CDD:293786
		ANK repeat	759..788	CDD:293786
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
Asb3	XP_038948182.1	Ank_4	28..74	CDD:372654	13/45 (29%)
		ANK repeat	53..87	CDD:293786	9/33 (27%)
		PHA02874	63..>356	CDD:165205	96/359 (27%)
		ANK repeat	89..120	CDD:293786	14/63 (22%)
		ANK repeat	157..187	CDD:293786	12/63 (19%)
		Ank_2	161..251	CDD:403870	37/123 (30%)
		ANK repeat	189..220	CDD:293786	11/30 (37%)
		ANK repeat	222..251	CDD:293786	14/28 (50%)
		ANK repeat	256..290	CDD:293786	6/33 (18%)
		ANK repeat	292..320	CDD:293786	10/27 (37%)
		ANK repeat	325..357	CDD:293786	8/39 (21%)
		SOCS_ASB3	469..519	CDD:239692
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24133
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010