DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ank and ANKDD1A

DIOPT Version :9

Sequence 1:NP_001162819.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_874362.3 Gene:ANKDD1A / 348094 HGNCID:28002 Length:522 Species:Homo sapiens


Alignment Length:556 Identity:145/556 - (26%)
Similarity:250/556 - (44%) Gaps:90/556 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   299 DGLTP----LHCASRSGHVEVIKHLLQQNAPILTKTKN--GLSALHMAAQGEHDEAAHLLLDNKA 357
            |||.|    ||.|:|..:|..::.|:.:.  :.|:.:|  |..|||.||...|::|..|||:::|
Human    10 DGLLPLERQLHEAARQNNVGRMQELIGRR--VNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEA 72

  Fly   358 PVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHG 422
            .|||  .|.:.||                     ..||...|...|.::.....::::::|:..|
Human    73 AVDE--EDAVGAL---------------------TEARLCFGMNALLLSAWFGHLRILQILVNSG 114

  Fly   423 ANIGATTESGLTPLHVASFMGCINIVIYLLQ--HEASADLPTIRGETPLHLAARANQADIIRILL 485
            |.|...::.|||.||.|:..|.:.::.::::  .:.:.|.....|.|..|.||...|.|.:..|:
Human   115 AKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLV 179

  Fly   486 RSAKVDAIA-REGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVL 549
            .|.....:. :||.|.||:|:..|::.::..|:..|.::..|:.:..:|||.||.....:.||:|
Human   180 GSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLL 244

  Fly   550 LENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGAS---IDFQGKNDVTPLHVATHYNNPSI 611
            |..|:..||:|:|..:.||.|...|.::|.::|:..|..   :|.||   .:|||:|..:|.|::
Human   245 LRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQG---ASPLHLAVRHNFPAL 306

  Fly   612 VELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVD 676
            |.||:.:.|..|......|..:|:|.:..:.:||..||..|.|:|:..|.|.:.|.:|.:..:|.
Human   307 VRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVS 371

  Fly   677 MVQLLLEYGVISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPL-HMAAHY--- 737
            :|.::::........|:     |.:...|..|  ....:|    .:.|:...:.| .:|:.|   
Human   372 LVDMIIKADRFYRWEKD-----HPSDPSGKSL--SFKQDH----RQETQQLRSVLWRLASRYLQP 425

  Fly   738 --------------GHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKA---- 784
                          .|:|.          ||..    :|......:.||.|:  |:..|..    
Human   426 REWKKLAYSWEFTEAHVDA----------IEQQ----WTGTRSYQEHGHRML--LIWLHGVATAG 474

  Fly   785 -NPNALTKDGNTALHIASNLGYVTVMESLKIVTSTS 819
             ||:....:|..|:......|:.|:..|....||.|
Human   475 ENPSKALFEGLVAIGRRDLAGWSTMARSQLTATSAS 510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_001162819.1 ANK 67..192 CDD:238125
ANK repeat 72..103 CDD:293786
Ank_2 77..167 CDD:289560
ANK repeat 105..136 CDD:293786
ANK repeat 138..169 CDD:293786
ANK 204..320 CDD:238125 9/24 (38%)
ANK repeat 204..231 CDD:293786
Ank_2 205..295 CDD:289560
ANK repeat 233..264 CDD:293786
ANK repeat 266..295 CDD:293786
ANK 294..419 CDD:238125 34/125 (27%)
ANK repeat 299..330 CDD:293786 11/34 (32%)
Ank_4 300..353 CDD:290365 20/58 (34%)
ANK repeat 332..363 CDD:293786 16/32 (50%)
Ank_2 337..428 CDD:289560 24/90 (27%)
ANK 360..485 CDD:238125 28/126 (22%)
ANK repeat 365..395 CDD:293786 3/29 (10%)
ANK repeat 398..427 CDD:293786 6/28 (21%)
ANK repeat 431..462 CDD:293786 8/32 (25%)
Ank_2 436..526 CDD:289560 23/92 (25%)
ANK repeat 464..494 CDD:293786 9/29 (31%)
ANK 491..616 CDD:238125 42/128 (33%)
ANK repeat 496..527 CDD:293786 9/30 (30%)
Ank_2 501..592 CDD:289560 29/93 (31%)
ANK repeat 529..560 CDD:293786 12/30 (40%)
ANK 557..682 CDD:238125 41/127 (32%)
ANK repeat 562..590 CDD:293786 8/30 (27%)
Ank_5 582..636 CDD:290568 18/56 (32%)
ANK repeat 595..625 CDD:293786 11/29 (38%)
ANK repeat 628..657 CDD:293786 9/28 (32%)
Ank_2 633..723 CDD:289560 20/89 (22%)
ANK repeat 661..691 CDD:293786 5/29 (17%)
ANK 692..812 CDD:238125 25/142 (18%)
ANK repeat 693..724 CDD:293786 4/30 (13%)
Ank_2 698..788 CDD:289560 20/112 (18%)
ANK repeat 726..755 CDD:293786 6/46 (13%)
ANK repeat 759..788 CDD:293786 8/33 (24%)
ZU5 930..1034 CDD:128514
Death_ank 1439..1521 CDD:260029
ANKDD1ANP_874362.3 ANK 1 14..43 8/30 (27%)
Ank_2 19..118 CDD:289560 33/123 (27%)
ANK repeat 19..45 CDD:293786 7/27 (26%)
ANK 43..179 CDD:238125 42/158 (27%)
ANK 2 47..76 13/28 (46%)
ANK repeat 48..78 CDD:293786 15/31 (48%)
ANK repeat 90..121 CDD:293786 6/30 (20%)
ANK 3 90..119 6/28 (21%)
Ank_2 95..189 CDD:289560 22/93 (24%)
ANK 122..245 CDD:238125 34/122 (28%)
ANK repeat 123..156 CDD:293786 8/32 (25%)
ANK 4 123..152 7/28 (25%)
ANK 5 158..187 9/28 (32%)
ANK repeat 159..189 CDD:293786 9/29 (31%)
Ank_2 163..253 CDD:289560 27/89 (30%)
ANK 186..311 CDD:238125 42/127 (33%)
ANK repeat 191..222 CDD:293786 9/30 (30%)
ANK 6 191..220 9/28 (32%)
ANK repeat 224..253 CDD:293786 10/28 (36%)
ANK 7 224..253 10/28 (36%)
ANK 252..377 CDD:238125 41/127 (32%)
ANK 8 257..286 8/28 (29%)
ANK repeat 260..288 CDD:293786 7/27 (26%)
Ank_2 262..354 CDD:289560 31/94 (33%)
ANK repeat 290..321 CDD:293786 13/33 (39%)
ANK 9 290..319 12/31 (39%)
ANK repeat 323..354 CDD:293786 10/30 (33%)
ANK 10 323..352 9/28 (32%)
ANK 11 356..385 5/28 (18%)
Death 426..494 CDD:260017 14/83 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.