DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ank and nompC

DIOPT Version :9

Sequence 1:NP_001162819.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_523483.2 Gene:nompC / 33768 FlyBaseID:FBgn0016920 Length:1761 Species:Drosophila melanogaster


Alignment Length:1055 Identity:285/1055 - (27%)
Similarity:471/1055 - (44%) Gaps:165/1055 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 ISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVDICCELLRRGIKIDNATK 104
            |..|.|..||:.....:.|.......:.:..|||..||||||:...||:...|:..|..:|....
  Fly   235 IPLLLAVESGNQSMCRELLAAQTAEQLKATTANGDTALHLAARRRDVDMVRILVDYGTNVDTQNG 299

  Fly   105 KGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPLYMAAQENHDNCCRTLLANGANPSL-- 167
            :|.|.||||:..|...::.......|:.::......||:::||:..|.:... :||:....|:  
  Fly   300 EGQTPLHIAAAEGDEALLKYFYGVRASASIADNQDRTPMHLAAENGHAHVIE-ILADKFKASIFE 363

  Fly   168 STEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLP------ALHIAAKKNDVNAAKLLLQHDPN 226
            .|:||.|.:.:|...||.:...:|.:..|  .:.:|      ::|.||..........|||....
  Fly   364 RTKDGSTLMHIASLNGHAECATMLFKKGV--YLHMPNKDGARSIHTAAAYGHTGIINTLLQKGEK 426

  Fly   227 ADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNY-VAKHNITPLHVACKWGKLSLCTLLLCR- 289
            .|:.:...:|.||||.......:...||...|||:. ..|...||||:|.:......|.|:|.: 
  Fly   427 VDVTTNDNYTALHIAVESAKPAVVETLLGFGADVHVRGGKLRETPLHIAARVKDGDRCALMLLKS 491

  Fly   290 GAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLD 354
            ||..:..|.|.|||:|.|:|.|::..:..||:.....|.|:..|.:.||||.:..|.:....|::
  Fly   492 GASPNLTTDDCLTPVHVAARHGNLATLMQLLEDEGDPLYKSNTGETPLHMACRACHPDIVRHLIE 556

  Fly   355 --------NKAP--VDEVTVDYLTALH-------------------------------------- 371
                    :||.  ::.|..|..||||                                      
  Fly   557 TVKEKHGPDKATTYINSVNEDGATALHYTCQITKEEVKIPESDKQIVRMLLENGADVTLQTKTAL 621

  Fly   372 --------------------------------------------VAAHCGHVKVAKLLLDYKANP 392
                                                        :|.|.||:::...||...|..
  Fly   622 ETAFHYCAVAGNNDVLMEMISHMNPTDIQKAMNRQSSVGWTPLLIACHRGHMELVNNLLANHARV 686

  Fly   393 NARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQ-HEA 456
            :.....|.:.||:|.::..:.:.:.|:.:.|.|.:.:..|.|.||:|:..|..::|.:|:: |.|
  Fly   687 DVFDTEGRSALHLAAERGYLHVCDALLTNKAFINSKSRVGRTALHLAAMNGFTHLVKFLIKDHNA 751

  Fly   457 SADLPTIRGETPLHLAARANQADIIRILLR-SAKVDAIAREGQTPLHVASRLGNINIIMLLL-QH 519
            ..|:.|:|.:|||||||.:.|.::.::||. .|.:||....||.|:|||::.....:..|.| ||
  Fly   752 VIDILTLRKQTPLHLAAASGQMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQH 816

  Fly   520 GAEINAQSNDKYSALHIAAKEGQENIVQVLLE---NG--AENNAVTKKGFTPLHLACKYGKQNVV 579
            .:.:||.|.|..:..||||.:|...:::.|::   :|  :..|.:|..  |||.||.:.|..:||
  Fly   817 PSLVNATSKDGNTCAHIAAMQGSVKVIEELMKFDRSGVISARNKLTDA--TPLQLAAEGGHADVV 879

  Fly   580 QILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEI 644
            :.|::.|||...:.|...|.:|:|....:..::::|....|......:.|...:|:|......:.
  Fly   880 KALVRAGASCTEENKAGFTAVHLAAQNGHGQVLDVLKSTNSLRINSKKLGLTPLHVAAYYGQADT 944

  Fly   645 AMQLLQH-----------GADV--NIISKSGFSPLHLAAQGGNVDMVQLLLEYG---VISAAAKN 693
            ..:||..           |..:  ::.::||.:||||||..||.::|:|||...   |.:|..:|
  Fly   945 VRELLTSVPATVKSETPTGQSLFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIEN 1009

  Fly   694 GLTPLHVAAQEGHVLVSQILLEHGAN-ISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSS 757
            |..|||:|...||:.|..:||...|. :..:.|||.|.||:||.:||:.:|:..:...|:|..:.
  Fly  1010 GYNPLHLACFGGHMSVVGLLLSRSAELLQSQDRNGRTGLHIAAMHGHIQMVEILLGQGAEINATD 1074

  Fly   758 NIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLGYVTV-------------- 808
            ..|:||||.||:.||:.::.||....|:|.:.|..|..|:..|::.|:..|              
  Fly  1075 RNGWTPLHCAAKAGHLEVVKLLCEAGASPKSETNYGCAAIWFAASEGHNEVLRYLMNKEHDTYGL 1139

  Fly   809 MESLKIVTSTSVI--NSNIGAIEEKLKVMTPELMQET--------LLSDSDDESCDDLL-DHNHY 862
            ||..:.|.:..|:  |.|...|:| ..:::|..:...        :||..:.|...||: .....
  Fly  1140 MEDKRFVYNLMVVSKNHNNKPIQE-FVLVSPAPVDTAAKLSNIYIVLSTKEKERAKDLVAAGKQC 1203

  Fly   863 KYMATDDLKANYGQDQKNFDTTNTDH---DLTDVSVLN-KKEILPNEMSCIELTEIGHKPDNVVI 923
            :.|||:.|....|.|........||.   :..||.:.| :||::.:.:....|.|:.|  .::..
  Fly  1204 EAMATELLALAAGSDSAGKILQATDKRNVEFLDVLIENEQKEVIAHTVVQRYLQELWH--GSLTW 1266

  Fly   924 ARSQVHLGFLVSFLV 938
            |..::.| .||:|:|
  Fly  1267 ASWKILL-LLVAFIV 1280

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_001162819.1 ANK 67..192 CDD:238125 37/126 (29%)
ANK repeat 72..103 CDD:293786 13/30 (43%)
Ank_2 77..167 CDD:289560 25/89 (28%)
ANK repeat 105..136 CDD:293786 8/30 (27%)
ANK repeat 138..169 CDD:293786 8/32 (25%)
ANK 204..320 CDD:238125 37/117 (32%)
ANK repeat 204..231 CDD:293786 7/26 (27%)
Ank_2 205..295 CDD:289560 28/91 (31%)
ANK repeat 233..264 CDD:293786 10/31 (32%)
ANK repeat 266..295 CDD:293786 10/29 (34%)
ANK 294..419 CDD:238125 39/216 (18%)
ANK repeat 299..330 CDD:293786 11/30 (37%)
Ank_4 300..353 CDD:290365 17/52 (33%)
ANK repeat 332..363 CDD:293786 9/40 (23%)
Ank_2 337..428 CDD:289560 28/182 (15%)
ANK 360..485 CDD:238125 41/207 (20%)
ANK repeat 365..395 CDD:293786 12/111 (11%)
ANK repeat 398..427 CDD:293786 7/28 (25%)
ANK repeat 431..462 CDD:293786 11/31 (35%)
Ank_2 436..526 CDD:289560 35/92 (38%)
ANK repeat 464..494 CDD:293786 14/30 (47%)
ANK 491..616 CDD:238125 41/130 (32%)
ANK repeat 496..527 CDD:293786 12/31 (39%)
Ank_2 501..592 CDD:289560 32/96 (33%)
ANK repeat 529..560 CDD:293786 9/35 (26%)
ANK 557..682 CDD:238125 38/137 (28%)
ANK repeat 562..590 CDD:293786 12/27 (44%)
Ank_5 582..636 CDD:290568 12/53 (23%)
ANK repeat 595..625 CDD:293786 5/29 (17%)
ANK repeat 628..657 CDD:293786 6/41 (15%)
Ank_2 633..723 CDD:289560 33/106 (31%)
ANK repeat 661..691 CDD:293786 16/32 (50%)
ANK 692..812 CDD:238125 46/134 (34%)
ANK repeat 693..724 CDD:293786 12/31 (39%)
Ank_2 698..788 CDD:289560 35/90 (39%)
ANK repeat 726..755 CDD:293786 12/28 (43%)
ANK repeat 759..788 CDD:293786 13/28 (46%)
ZU5 930..1034 CDD:128514 5/9 (56%)
Death_ank 1439..1521 CDD:260029
nompCNP_523483.2 ANK repeat 129..157 CDD:293786
Ank_2 131..228 CDD:289560
ANK 155..319 CDD:238125 27/83 (33%)
ANK repeat 159..186 CDD:293786
ANK repeat 232..265 CDD:293786 6/29 (21%)
Ank_2 237..331 CDD:289560 27/93 (29%)
ANK 263..387 CDD:238125 37/124 (30%)
ANK repeat 267..298 CDD:293786 13/30 (43%)
ANK repeat 300..331 CDD:293786 8/30 (27%)
Ank_2 305..398 CDD:289560 23/95 (24%)
ANK 329..454 CDD:238125 30/127 (24%)
ANK repeat 367..398 CDD:293786 8/32 (25%)
ANK repeat 400..431 CDD:293786 7/30 (23%)
Ank_2 405..498 CDD:289560 28/92 (30%)
ANK 428..555 CDD:238125 41/126 (33%)
ANK repeat 433..463 CDD:293786 10/29 (34%)
ANK repeat 469..499 CDD:293786 10/29 (34%)
ANK 496..641 CDD:238125 28/144 (19%)
ANK repeat 501..532 CDD:293786 11/30 (37%)
Ank_2 507..616 CDD:289560 23/108 (21%)
ANK repeat 534..575 CDD:293786 9/40 (23%)
ANK repeat 577..616 CDD:293786 5/38 (13%)
Ank_2 625..722 CDD:289560 14/96 (15%)
ANK 654..780 CDD:238125 35/125 (28%)
ANK repeat 660..690 CDD:293786 7/29 (24%)
ANK repeat 692..723 CDD:293786 7/30 (23%)
Ank_2 697..790 CDD:289560 32/92 (35%)
ANK 720..847 CDD:238125 45/126 (36%)
ANK repeat 725..757 CDD:293786 11/31 (35%)
ANK repeat 759..790 CDD:293786 14/30 (47%)
Ank_5 779..834 CDD:290568 20/54 (37%)
ANK 787..915 CDD:238125 41/129 (32%)
ANK repeat 792..824 CDD:293786 12/31 (39%)
ANK repeat 861..893 CDD:293786 13/33 (39%)
Ank_4 865..915 CDD:290365 16/49 (33%)
Ank_4 929..995 CDD:290365 18/65 (28%)
ANK repeat 932..972 CDD:293786 5/39 (13%)
ANK 969..1096 CDD:238125 50/126 (40%)
ANK repeat 974..1007 CDD:293786 16/32 (50%)
Ank_2 979..1074 CDD:289560 38/94 (40%)
ANK repeat 1009..1041 CDD:293786 12/31 (39%)
ANK 1039..1159 CDD:238125 38/119 (32%)
ANK repeat 1043..1074 CDD:293786 12/30 (40%)
Ank_2 1048..1135 CDD:289560 28/86 (33%)
ANK repeat 1076..1101 CDD:293786 11/24 (46%)
ANK repeat 1109..1134 CDD:293786 5/24 (21%)
Ion_trans <1393..1598 CDD:278921
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm3248
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.810

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