DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ank and Ankdd1a

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001357800.1	Gene:	Ankdd1a / 330963	MGIID:	2686319	Length:	519	Species:	Mus musculus

Alignment Length:	391	Identity:	108/391 - (27%)
Similarity:	196/391 - (50%)	Gaps:	40/391 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 GLTP----LHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAPVD 360
            ||.|    ||.|||...||.:|.|.::...|..:...|..|||.||...|::|..|||:..|.||
Mouse    11 GLLPLERQLHEASRWNQVERMKELFEKRVNIRARNHVGRVALHWAAGAGHEQAVRLLLERGAAVD 75

  Fly   361 EVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANI 425
            :|....:.:|.::|..||:::                                 |::|:..||.:
Mouse    76 DVDSFGMNSLLLSAWFGHLQI---------------------------------VQILVNAGAKV 107

  Fly   426 GATTESGLTPLHVASFMGCINIVIYLLQ--HEASADLPTIRGETPLHLAARANQADIIRILLRSA 488
            ...::.|||.||.|:..|.:.::.::::  .:.:.|.....|.|..|.||...|.|.:..|:.|.
Mouse   108 HCESKDGLTLLHCAAQKGHVPVLAFVMEDLEDVALDHADKLGRTAFHRAAEHGQLDALDFLVGSG 172

  Fly   489 KVDAIA-REGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLEN 552
            ...::. :.|.|.||:|:..|:::::..|:..|.::..|:.:..:|||.||:....:.|.:||..
Mouse   173 CDHSVKDKGGNTALHLAASQGHVDVLQRLVDIGLDLEEQNTEGLTALHAAAEGIHADCVMLLLGA 237

  Fly   553 GAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLK 617
            |:..||:|:|..:.||.|...|.:::.:.|::.|...:...|...||:|:|..:|.|.:|:||:.
Mouse   238 GSNVNALTQKRLSCLHYAALGGSEDLSRALIKAGGCTNVADKQGTTPMHLAVKHNFPGLVQLLID 302

  Fly   618 NGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLL 682
            ..|..:......|..:|:|.:..:.::|..||..|||:::..|.|.:.|.:||:..:|.:|.:::
Mouse   303 GHSDLDAVDIRRQTPLHLAAEHAWQDVADMLLIAGADLSLRDKQGKTALAVAARSNHVSLVDMII 367

  Fly   683 E 683
            :
Mouse   368 K 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125
		ANK repeat	72..103	CDD:293786
		Ank_2	77..167	CDD:289560
		ANK repeat	105..136	CDD:293786
		ANK repeat	138..169	CDD:293786
		ANK	204..320	CDD:238125	11/23 (48%)
		ANK repeat	204..231	CDD:293786
		Ank_2	205..295	CDD:289560
		ANK repeat	233..264	CDD:293786
		ANK repeat	266..295	CDD:293786
		ANK	294..419	CDD:238125	33/122 (27%)
		ANK repeat	299..330	CDD:293786	13/33 (39%)
		Ank_4	300..353	CDD:290365	22/56 (39%)
		ANK repeat	332..363	CDD:293786	14/30 (47%)
		Ank_2	337..428	CDD:289560	21/90 (23%)
		ANK	360..485	CDD:238125	25/126 (20%)
		ANK repeat	365..395	CDD:293786	4/29 (14%)
		ANK repeat	398..427	CDD:293786	4/28 (14%)
		ANK repeat	431..462	CDD:293786	8/32 (25%)
		Ank_2	436..526	CDD:289560	22/92 (24%)
		ANK repeat	464..494	CDD:293786	9/29 (31%)
		ANK	491..616	CDD:238125	37/125 (30%)
		ANK repeat	496..527	CDD:293786	8/30 (27%)
		Ank_2	501..592	CDD:289560	26/90 (29%)
		ANK repeat	529..560	CDD:293786	11/30 (37%)
		ANK	557..682	CDD:238125	37/124 (30%)
		ANK repeat	562..590	CDD:293786	7/27 (26%)
		Ank_5	582..636	CDD:290568	15/53 (28%)
		ANK repeat	595..625	CDD:293786	10/29 (34%)
		ANK repeat	628..657	CDD:293786	9/28 (32%)
		Ank_2	633..723	CDD:289560	15/51 (29%)
		ANK repeat	661..691	CDD:293786	6/23 (26%)
		ANK	692..812	CDD:238125
		ANK repeat	693..724	CDD:293786
		Ank_2	698..788	CDD:289560
		ANK repeat	726..755	CDD:293786
		ANK repeat	759..788	CDD:293786
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
Ankdd1a	NP_001357800.1	Ank_2	19..108	CDD:372319	33/121 (27%)
		ANK repeat	19..45	CDD:293786	10/25 (40%)
		ANK repeat	47..78	CDD:293786	14/30 (47%)
		ANK repeat	80..110	CDD:293786	8/62 (13%)
		PHA03095	96..>368	CDD:222980	76/304 (25%)
		ANK repeat	113..146	CDD:293786	8/32 (25%)
		ANK repeat	149..179	CDD:293786	9/29 (31%)
		ANK repeat	181..212	CDD:293786	8/30 (27%)
		ANK repeat	214..243	CDD:293786	9/28 (32%)
		ANK repeat	250..278	CDD:293786	6/27 (22%)
		ANK repeat	280..311	CDD:293786	10/30 (33%)
		ANK repeat	313..344	CDD:293786	9/30 (30%)
		DD	420..491	CDD:387368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900