DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank and Ank1

DIOPT Version :9

Sequence 1:NP_001162819.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:XP_038950490.1 Gene:Ank1 / 306570 RGDID:1309620 Length:1946 Species:Rattus norvegicus


Alignment Length:1575 Identity:722/1575 - (45%)
Similarity:988/1575 - (62%) Gaps:112/1575 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 MALDNKNGIIKQNDATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVDI 88
            :.|.||.|..|. ||..|||||||||::.|.:|.|..|  .|||:||.||||.||||:|:|:|.:
  Rat    46 LVLSNKMGFCKA-DAATSFLRAARSGNLDKALDHLRNG--VDINTCNQNGLNGLHLASKEGHVKM 107

  Fly    89 CCELLRRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPLYMAAQENHDN 153
            ..|||.:.|.::..|||||||||||:||||.:|:.:|:.|.||||.||..|||||||||||||..
  Rat   108 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 172

  Fly   154 CCRTLLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAK 218
            ..:.||.||||.:::|||||||||||:||||:.:||.|:....:||||||||||||:.:|...|.
  Rat   173 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 237

  Fly   219 LLLQHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLC 283
            :|||:|||.|::||:|||||||||||.|:::|.||||..|.||:..::.|||||:|.:.|.:.:.
  Rat   238 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 302

  Fly   284 TLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEA 348
            .|||.|||:|:..|:|.|||||||:|:|||.:.:.||...|||..|||||||.:||||||:|.:.
  Rat   303 RLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 367

  Fly   349 AHLLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIK 413
            ..|||...|.:|::|:|:||.|||||||||.:|||:|||..|.||:||||||||||||||||.|:
  Rat   368 VRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIR 432

  Fly   414 MVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQA 478
            ::|||:|.||:|.|.|||||||||||||||.:.||..|||..||.::..::.|||||:||||...
  Rat   433 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHT 497

  Fly   479 DIIRILLRS-AKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQ 542
            ::.:.||:: ||.:|.|::.|||||.|:|:|:.:::.|||::.|..|..:...::.||.||:||.
  Rat   498 EVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTSMVKLLLENDASPNLATTAGHTPLHTAAREGH 562

  Fly   543 ENIVQVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYN 607
            .:....|||..|....:|||||||||:|.||||..:.::||::.|..:..|||.:||||||.|:|
  Rat   563 VDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHN 627

  Fly   608 NPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQG 672
            |..||:|||..|.||:..|.||...:|||.|:|.:|:|..|||:|...|..|..|.:|||||||.
  Rat   628 NLDIVQLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQE 692

  Fly   673 GNVDMVQLLLEYGVISAAA------KNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPL 731
            |:.:||.|||     |..|      |:||||||:.||||||.|:.:|::||..:...||.|||||
  Rat   693 GHTEMVALLL-----SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVTVDATTRMGYTPL 752

  Fly   732 HMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTA 796
            |:|:|||::.||||.:::.||:...:.:||:||||||||||..|:.|||::.|:||.::.:|.|.
  Rat   753 HVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSNGTTP 817

  Fly   797 LHIASNLGYVTVMESLKIVT-STSVINSNIGAIEEKLKVMTPELMQETLLSDSDDESC------- 853
            |.||..|||::|.:.||:|| .|||:     .:.:|.::..||.:.| :|..|:||..       
  Rat   818 LAIAKRLGYISVTDVLKVVTDETSVV-----LVSDKHRMSYPETVDE-ILDVSEDEGTAHISLTG 876

  Fly   854 DDLLDHNHYKYMATDDLKANYGQDQKNFD-TTNTDHDLTDVSVLNKKEILP-------------- 903
            |:|:.....:..:.|     .|::::..| ....|..:...::.....:.|              
  Rat   877 DELVGSKAERRDSRD-----VGEEKELLDFVPKLDQVVESPAIPRIPCVTPETVVIRSEDQEQAS 936

  Fly   904 ---NEMSCIELTEIGHKPDNVVIARSQVHLGFLVSFLVDARGGSMRGYRHNGVRIIVPPKACAEP 965
               :|.|.|..:......||:....|.||.||||||:||||||||||.||||:|:::||:.||.|
  Rat   937 KEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAP 1001

  Fly   966 TRITCRYVKPQRVVNPPPLMEGEALVSRILEMSPVDGMFLSPITLEVPHYGTLRKNEREIIILRS 1030
            ||||||.||||::..||||.|.|.|.|||:.:.|....||||:.:|:||:.:..:.:||:::|||
  Rat  1002 TRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRS 1066

  Fly  1031 DNGESWREH-----NLYKDII----GEDINQTEEFHSDRIVRIVTQNVPHFFAVVSRVRQEVHVI 1086
            :||..|:||     ..|.|.|    .|::...||....|:.||:|.:.|.:|.::||:.|:...|
  Rat  1067 ENGSVWKEHKSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTI 1131

  Fly  1087 GPDGGTVFSTAVPQVKAIFPPHALTKKIRVGLQAQSVDLVECSKLLGQGVAVSPVVTVEPRRRKF 1151
            ||:||::.|..||.|:|.||.:|:|||:::.||||.|.....:||||.....||:||||||||||
  Rat  1132 GPEGGSLRSKLVPLVQATFPENAVTKKVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKF 1196

  Fly  1152 HKAITLSIPAPKACTNSMVNACYGNGNSSSPTLRLLCSISGGQTRATWEDVTGSTPLSFVRDSVT 1216
            |:.|.|.||.|.:.|::..::  |.|:::|  ||||||:.||..:|.|||:||:|.|.:..:...
  Rat  1197 HRPIGLRIPLPPSWTDNPRDS--GEGDTTS--LRLLCSVIGGTDQAQWEDITGTTKLVYANECAN 1257

  Fly  1217 FTTTVSARFWLIDCRNIIDAGRMATELYSHLAKVPFYVKFVIFAKRISQTEAKFSVFCMTDDKED 1281
            |||.|||||||.||....:|...||.||..|..||:..|||||||.....|.:...:||||||.|
  Rat  1258 FTTNVSARFWLSDCPRTAEAVHFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVD 1322

  Fly  1282 KTLEQQEYFKEVAKSRDIEVLQNQIVYLEFAGNIVPILKKGEQLYTKFQPFCENRLSFSAHIKD- 1345
            |||||.|.|.|||:|||||||:...::.|.:||:||:.|..:|....||.|.||||:....::| 
  Rat  1323 KTLEQHENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAIPVKVRDS 1387

  Fly  1346 QEFPHGRICFMTYPMVGPDEVPLKPLCTLNISVDFKTITNHLERDNLHSLNDCINAHGKLNHNEN 1410
            ...|.|.:.|:..||...|...:  ||.||:                 ::..|....|..:    
  Rat  1388 SREPGGFLSFLRKPMKYEDAQHI--LCHLNV-----------------TMPPCTKGSGAED---- 1429

  Fly  1411 IVFGVKEQQVKKIDITKACIMSSDIKLIHEADVI---LDDICSHLGSDWPLLANVLGVSQADIDL 1472
                 :.:.:..:.:..:.:..|.:....:.|.:   :..|..|||..|..||..|..|..||:.
  Rat  1430 -----RRRTLTPLTLRYSILSESRLGFTSDTDRVEMKMAVIREHLGLSWAELARELQFSVEDINR 1489

  Fly  1473 VKTEFLLNDSVKQSMAMLQLWLEHGGILTGNVLAEALY----KIGRSDIVEKSFKNAEFGTHQPE 1533
            ::.| ..|..:.||.|:|.||::..|   .|...|.||    .|.||:||..    .|....|..
  Rat  1490 IRVE-NPNSLLDQSTALLTLWVDREG---ENAKMENLYTALRNIDRSEIVNM----LEGSGRQSR 1546

  Fly  1534 KVLPTAGIEKDGDYE 1548
            .:.|.   .:.||.|
  Rat  1547 NLKPD---RRHGDRE 1558

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_001162819.1 ANK 67..192 CDD:238125 78/124 (63%)
ANK repeat 72..103 CDD:293786 15/30 (50%)
Ank_2 77..167 CDD:289560 54/89 (61%)
ANK repeat 105..136 CDD:293786 20/30 (67%)
ANK repeat 138..169 CDD:293786 19/30 (63%)
ANK 204..320 CDD:238125 64/115 (56%)
ANK repeat 204..231 CDD:293786 15/26 (58%)
Ank_2 205..295 CDD:289560 50/89 (56%)
ANK repeat 233..264 CDD:293786 20/30 (67%)
ANK repeat 266..295 CDD:293786 14/28 (50%)
ANK 294..419 CDD:238125 78/124 (63%)
ANK repeat 299..330 CDD:293786 17/30 (57%)
Ank_4 300..353 CDD:290365 31/52 (60%)
ANK repeat 332..363 CDD:293786 16/30 (53%)
Ank_2 337..428 CDD:289560 58/90 (64%)
ANK 360..485 CDD:238125 79/124 (64%)
ANK repeat 365..395 CDD:293786 21/29 (72%)
ANK repeat 398..427 CDD:293786 21/28 (75%)
ANK repeat 431..462 CDD:293786 20/30 (67%)
Ank_2 436..526 CDD:289560 43/90 (48%)
ANK repeat 464..494 CDD:293786 14/30 (47%)
ANK 491..616 CDD:238125 57/124 (46%)
ANK repeat 496..527 CDD:293786 13/30 (43%)
Ank_2 501..592 CDD:289560 37/90 (41%)
ANK repeat 529..560 CDD:293786 10/30 (33%)
ANK 557..682 CDD:238125 65/124 (52%)
ANK repeat 562..590 CDD:293786 15/27 (56%)
Ank_5 582..636 CDD:290568 27/53 (51%)
ANK repeat 595..625 CDD:293786 18/29 (62%)
ANK repeat 628..657 CDD:293786 13/28 (46%)
Ank_2 633..723 CDD:289560 46/95 (48%)
ANK repeat 661..691 CDD:293786 15/29 (52%)
ANK 692..812 CDD:238125 63/119 (53%)
ANK repeat 693..724 CDD:293786 16/30 (53%)
Ank_2 698..788 CDD:289560 48/89 (54%)
ANK repeat 726..755 CDD:293786 16/28 (57%)
ANK repeat 759..788 CDD:293786 18/28 (64%)
ZU5 930..1034 CDD:128514 60/103 (58%)
Death_ank 1439..1521 CDD:260029 30/88 (34%)
Ank1XP_038950490.1 ANK repeat 61..89 CDD:293786 16/29 (55%)
Ank_2 63..154 CDD:403870 54/92 (59%)
ANK repeat 91..122 CDD:293786 15/30 (50%)
ANK repeat 125..155 CDD:293786 19/29 (66%)
PHA02876 <137..>482 CDD:165207 210/344 (61%)
ANK repeat 157..188 CDD:293786 19/30 (63%)
ANK repeat 190..214 CDD:293786 16/23 (70%)
ANK repeat 223..250 CDD:293786 15/26 (58%)
ANK repeat 253..283 CDD:293786 20/29 (69%)
ANK repeat 285..316 CDD:293786 14/30 (47%)
ANK repeat 318..349 CDD:293786 17/30 (57%)
ANK repeat 351..382 CDD:293786 16/30 (53%)
ANK repeat 387..415 CDD:293786 19/27 (70%)
ANK repeat 417..448 CDD:293786 22/30 (73%)
PHA02875 429..>639 CDD:165206 104/209 (50%)
ANK repeat 450..481 CDD:293786 20/30 (67%)
ANK repeat 483..514 CDD:293786 14/30 (47%)
ANK repeat 516..545 CDD:293786 12/28 (43%)
ANK repeat 550..580 CDD:293786 10/29 (34%)
ANK repeat 582..613 CDD:293786 15/30 (50%)
Ank_2 593..>806 CDD:423045 109/217 (50%)
ANK repeat 615..643 CDD:293786 17/27 (63%)
ANK repeat 648..679 CDD:293786 14/30 (47%)
ANK repeat 681..712 CDD:293786 16/35 (46%)
ANK repeat 714..745 CDD:293786 16/30 (53%)
ANK repeat 747..778 CDD:293786 16/30 (53%)
ANK repeat 780..808 CDD:293786 17/27 (63%)
Ank_4 781..833 CDD:372654 28/51 (55%)
ZU5 966..1070 CDD:128514 60/103 (58%)
UPA_2 1291..1420 CDD:375346 59/147 (40%)
Death_ank1 1456..1539 CDD:260067 30/90 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166351944
Domainoid 1 1.000 139 1.000 Domainoid score I4656
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47562
OrthoDB 1 1.010 - - D1011028at2759
OrthoFinder 1 1.000 - - FOG0000917
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100012
Panther 1 1.100 - - LDO PTHR24133
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.860

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