DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank and Ankrd28

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_038950906.1	Gene:	Ankrd28 / 306264	RGDID:	1559931	Length:	1053	Species:	Rattus norvegicus

Alignment Length:	871	Identity:	248/871 - (28%)
Similarity:	376/871 - (43%)	Gaps:	130/871 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NKNGIIKQNDATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVDICCEL 92
            |.|...|::...|.:  ||..|.|:.|...:..|  :::...:......||.||..|.:.:...|
  Rat   165 NINAFDKKDRRAIHW--AAYMGHIEVVKLLVSHG--AEVTCKDKKSYTPLHAAASSGMISVVKYL 225

  Fly    93 LRRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPLYMAAQENHDNCCRT 157
            |..|:.::.....|||.||:|...||..|:|:||...||||.::..|||||:.||...|...|..
  Rat   226 LDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGANVNQKNERGFTPLHFAAASTHGALCLE 290

  Fly   158 LL-ANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAKLLL 221
            || .|||:.::.::||.||                             ||:.|.....:.::.::
  Rat   291 LLVGNGADVNMKSKDGKTP-----------------------------LHMTALHGRFSRSQTII 326

  Fly   222 QHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLL 286
            |.....|...|:|.|||||||.||:..:...|:.:.||......|.:.|||:|...|....|..|
  Rat   327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKL 391

  Fly   287 LCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHL 351
            |..|..||.....|.|.||.|:..|::|.:..||...|....|.|.|.|.||.||...:.:....
  Rat   392 LSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFA 456

  Fly   352 LLDNKAPVDEVTVDYLTALHVAAHCG-HVKVAKLLLDYKANPNARALNGF--------------- 400
            |:.:.|.|:::.....|.||.||... ..|..:.||...|||..|...|:
  Rat   457 LVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCL 521

  Fly   401 ------------------------------TPLHIACKKNRIKMVELLIKHGANIGATTESGLTP 435
                                          :|||:|......:.:|:|::...::.....||.||
  Rat   522 QLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTP 586

  Fly   436 LHVASFMGCINIVIYLLQHEASADLPT-IRGETPLHLAARANQADIIRILLRSAK----VDAIAR 495
            |.:|:|.|.:..|..|:...||..:.. :...||:|.||....::.:|:|:.:|:    ||....
  Rat   587 LDLAAFKGHVECVDVLINQGASILVKDYVLKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDG 651

  Fly   496 EGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVT 560
            .|||||.::...|:.:.:..||..||.::|:.....:|||..|..|.|..|..||::||:.....
  Rat   652 NGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRD 716

  Fly   561 KKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLC 625
            .:|.||:||:...|...|:..|||:..|:|                .||:||:
  Rat   717 SRGRTPIHLSAACGHIGVLGALLQSATSVD----------------ANPAIVD------------ 753

  Fly   626 ARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLE---YGVI 687
             .:|..|:|.||...: |..::||........|..:.|||||.|....|....::|::   ..::
  Rat   754 -NHGYTALHWACYNGH-ETCVELLLEQDVFQKIDGNAFSPLHCAVINDNEGAAEMLIDTLGASIV 816

  Fly   688 SAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIEN-DA 751
            :|....|.||||.||...||...|:||...|.::.....|.|||.|||..|..:.|:..:.: .|
  Rat   817 NAPDSKGRTPLHAAAFTDHVECLQLLLSQNAQVNSADSTGKTPLMMAAENGQTNTVEMLVSSASA 881

  Fly   752 DIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDG---NTALHIASNLGYVTVMESLK 813
            |:.:......|.||.|..:||.....|:|....:.|.:....   .|.||:|:..|...|::.|
  Rat   882 DLTLQDKSKNTALHLACGKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQEL- 945

  Fly   814 IVTSTSVINSNIGAIEEKLKVMTPEL 839
            :....||:     |::|  ...||.|
  Rat   946 LGKGASVL-----AVDE--NGYTPAL 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125	42/125 (34%)
		ANK repeat	72..103	CDD:293786	8/30 (27%)
		Ank_2	77..167	CDD:289560	38/90 (42%)
		ANK repeat	105..136	CDD:293786	16/30 (53%)
		ANK repeat	138..169	CDD:293786	14/31 (45%)
		ANK	204..320	CDD:238125	38/115 (33%)
		ANK repeat	204..231	CDD:293786	5/26 (19%)
		Ank_2	205..295	CDD:289560	30/89 (34%)
		ANK repeat	233..264	CDD:293786	13/30 (43%)
		ANK repeat	266..295	CDD:293786	11/28 (39%)
		ANK	294..419	CDD:238125	40/170 (24%)
		ANK repeat	299..330	CDD:293786	10/30 (33%)
		Ank_4	300..353	CDD:290365	18/52 (35%)
		ANK repeat	332..363	CDD:293786	9/30 (30%)
		Ank_2	337..428	CDD:289560	26/136 (19%)
		ANK	360..485	CDD:238125	37/171 (22%)
		ANK repeat	365..395	CDD:293786	11/30 (37%)
		ANK repeat	398..427	CDD:293786	7/73 (10%)
		ANK repeat	431..462	CDD:293786	12/30 (40%)
		Ank_2	436..526	CDD:289560	28/94 (30%)
		ANK repeat	464..494	CDD:293786	10/33 (30%)
		ANK	491..616	CDD:238125	39/124 (31%)
		ANK repeat	496..527	CDD:293786	11/30 (37%)
		Ank_2	501..592	CDD:289560	30/90 (33%)
		ANK repeat	529..560	CDD:293786	11/30 (37%)
		ANK	557..682	CDD:238125	32/124 (26%)
		ANK repeat	562..590	CDD:293786	11/27 (41%)
		Ank_5	582..636	CDD:290568	12/53 (23%)
		ANK repeat	595..625	CDD:293786	4/29 (14%)
		ANK repeat	628..657	CDD:293786	8/28 (29%)
		Ank_2	633..723	CDD:289560	29/92 (32%)
		ANK repeat	661..691	CDD:293786	9/32 (28%)
		ANK	692..812	CDD:238125	39/123 (32%)
		ANK repeat	693..724	CDD:293786	13/30 (43%)
		Ank_2	698..788	CDD:289560	29/90 (32%)
		ANK repeat	726..755	CDD:293786	11/29 (38%)
		ANK repeat	759..788	CDD:293786	8/28 (29%)
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
Ankrd28	XP_038950906.1	ANK repeat	12..38	CDD:293786
		PHA03095	22..>310	CDD:222980	52/177 (29%)
		ANK repeat	40..71	CDD:293786
		ANK repeat	76..104	CDD:293786
		ANK repeat	106..137	CDD:293786
		ANK repeat	140..170	CDD:293786	2/4 (50%)
		ANK repeat	172..203	CDD:293786	7/34 (21%)
		PHA03095	186..>454	CDD:222980	94/298 (32%)
		ANK repeat	205..236	CDD:293786	8/30 (27%)
		ANK repeat	238..269	CDD:293786	16/30 (53%)
		ANK repeat	271..302	CDD:293786	14/30 (47%)
		ANK repeat	305..336	CDD:293786	9/59 (15%)
		ANK repeat	338..363	CDD:293786	11/24 (46%)
		ANK repeat	371..402	CDD:293786	12/30 (40%)
		ANK repeat	404..435	CDD:293786	10/30 (33%)
		ANK repeat	437..468	CDD:293786	9/30 (30%)
		ANK repeat	470..502	CDD:293786	11/31 (35%)
		Ank_2	475..580	CDD:403870	18/104 (17%)
		ANK repeat	552..580	CDD:293786	6/27 (22%)
		PHA02874	554..>863	CDD:165205	100/338 (30%)
		ANK repeat	582..613	CDD:293786	12/30 (40%)
		ANK repeat	618..650	CDD:293786	10/31 (32%)
		ANK repeat	652..683	CDD:293786	11/30 (37%)
		ANK repeat	685..716	CDD:293786	11/30 (37%)
		ANK repeat	718..747	CDD:293786	12/44 (27%)
		ANK repeat	755..820	CDD:293786	18/65 (28%)
		ANK repeat	823..853	CDD:293786	13/29 (45%)
		Ank_2	827..920	CDD:403870	30/92 (33%)
		ANK repeat	855..887	CDD:293786	11/31 (35%)
		ANK repeat	889..920	CDD:293786	9/30 (30%)
		ANK repeat	925..956	CDD:293786	10/36 (28%)
		Ank	927..957	CDD:394980	10/35 (29%)
		Ank_2	930..1006	CDD:423045	13/43 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810