DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank and Tnks

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001099554.2	Gene:	Tnks / 290794	RGDID:	1308784	Length:	1317	Species:	Rattus norvegicus

Alignment Length:	1187	Identity:	302/1187 - (25%)
Similarity:	484/1187 - (40%)	Gaps:	254/1187 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GIIKQNDATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNA--LHLAAKDGYVDICCELL 93
            |:...:.|....|.|.|:||:.:|...:|.   :::|:.:..|..:  ||.||..|..|:...||
  Rat   165 GVPAVSGALRELLEACRNGDVSRVKRLVDA---ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLL 226

  Fly    94 RRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPLYMAAQENHDNCCRTL 158
            :.|..:......|...||.|...|..:|::.|:...|:.|.:....:|||:.||.:...:.|..|
  Rat   227 QMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 291

  Fly   159 LANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAKLLLQH 223
            |.:||:|::...||.:.|.:|     |.....:|..:.:....|.|   |...|:.....||...
  Rat   292 LQHGADPNIRNTDGKSALDLA-----DPSAKAVLTGEYKKDELLEA---ARSGNEEKLMALLTPL 348

  Fly   224 DPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLC 288
            :.|.........||||:||.|..|.|..|||.:.|||:...|..:.|||.||.:|...:..|||.
  Rat   349 NVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 413

  Fly   289 RGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGE------HDE 347
            .||.::|......||||.|:....|||...||...|.......:|.||:.||...|      ::.
  Rat   414 HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEF 478

  Fly   348 AAHLLLDNKAPVDEVTVDYLTALHV-----------AAHCG----HVK---VAKLLLDYKANPNA 394
            ..|.||......|...|....||.:           |.||.    |.|   ||:|||...||.|.
  Rat   479 KGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVAELLLRKGANVNE 543

  Fly   395 RALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASAD 459
            :..:..||||:|.::....::|:|.||||.:.|....|.|.||.|:..|.:.....||.:.:...
  Rat   544 KNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPS 608

  Fly   460 LPTIRGETPLHLAARANQADIIRIL-----LRSAKVDAIAREGQTPLHVASRLGNINIIMLLLQH 519
            :.:::|.|    ||:.....:.:||     :|::.||....|       ||:.|::..:..|..
  Rat   609 IISLQGFT----AAQMGNEAVQQILSESTPIRTSDVDYRLLE-------ASKAGDLETVKQLCS- 661

  Fly   520 GAEINAQS-NDKYSA-LHIAAKEGQENIVQVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQIL 582
            ...:|.:. ..::|. ||.||...:.::|:.||.:||:.:|..|.|..|||.||.||...|.::|
  Rat   662 PQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELL 726

  Fly   583 LQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQ 647
            :::|||::.......||||.|                                |.|..| ||...
  Rat   727 VRHGASVNVADLWKFTPLHEA--------------------------------AAKGKY-EICKL 758

  Fly   648 LLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGVISAAAKNGL----------------- 695
            ||:||||....::.|.:||.|..: |:.|:..||.....:..|||.|.
  Rat   759 LLKHGADPTKKNRDGNTPLDLVKE-GDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRD 822

  Fly   696 ------TPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIE 754
                  ||||:||...::.|::.|||.||:::.:.:.|..|||.||.|||:|:....|:.:..:.
  Rat   823 TQGRNSTPLHLAAGYNNLEVAEYLLERGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVN 887

  Fly   755 MSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLGYVTVMESLKIVTSTS 819
            .:....:||||:|||:|...:..|||.|.|:|....::|.|.|.:|:
  Rat   888 ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT------------------ 934

  Fly   820 VINSNIGAIEEKLKVMTPE-----------LMQETLLSDSDDESCDDLLDHNHYKYMATDDLKAN 873
              ..:|.|:  .:..|.||           ::..:|:|.:...||.....       :.|:|...
  Rat   935 --ADDIRAL--LIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAAS-------SIDNLTGP 988

  Fly   874 Y----------------GQDQKNFDTTNTDHD----LTDVSVLNKKEILPNEMSCIE-LTEIGHK 917
            .                |.::|..:....|.:    |..:.:.:.::|...|...:: |.::||:
  Rat   989 LAELAVGGASNAGDGAAGAERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHE 1053

  Fly   918 PDNVVIARSQVHLGFLVSFLVDARGGSMRGYRHNGVRIIVPPKACAEPTRITCRYVKPQRVVNPP 982
            ....:                   |.:..|:||..::.:.             |.:..|:..||.
  Rat  1054 ELKEI-------------------GINAYGHRHKLIKGVE-------------RLLGGQQGTNPY 1086

  Fly   983 PLMEGEALVSRILEMSPVDGMFLSPITLEVPHYGTLRKNEREIIILRSDNGESWREHNLYKDI-I 1046
            .........:.:|:::|.|..:.|   :|.....|:|::.        |.|.:....|.|..| |
  Rat  1087 LTFHCVNQGTILLDLAPEDKEYQS---VEEEMQSTIREHR--------DGGNAGGIFNRYNVIRI 1140

  Fly  1047 GEDINQ-------------TEEFHSDRIVRIVTQNVPHFFAVVSRVRQEVH-------------- 1084
            .:.:|:             :||.|:....|::....|...|::.:...|.|
  Rat  1141 QKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFA 1205

  Fly  1085 ---------VIGPDGGT 1092
                     |.|..|||
  Rat  1206 ENSSKSNQYVYGIGGGT 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125	36/126 (29%)
		ANK repeat	72..103	CDD:293786	10/32 (31%)
		Ank_2	77..167	CDD:289560	29/89 (33%)
		ANK repeat	105..136	CDD:293786	9/30 (30%)
		ANK repeat	138..169	CDD:293786	11/30 (37%)
		ANK	204..320	CDD:238125	42/115 (37%)
		ANK repeat	204..231	CDD:293786	6/26 (23%)
		Ank_2	205..295	CDD:289560	32/89 (36%)
		ANK repeat	233..264	CDD:293786	15/30 (50%)
		ANK repeat	266..295	CDD:293786	11/28 (39%)
		ANK	294..419	CDD:238125	44/148 (30%)
		ANK repeat	299..330	CDD:293786	11/30 (37%)
		Ank_4	300..353	CDD:290365	18/58 (31%)
		ANK repeat	332..363	CDD:293786	10/36 (28%)
		Ank_2	337..428	CDD:289560	34/114 (30%)
		ANK	360..485	CDD:238125	43/147 (29%)
		ANK repeat	365..395	CDD:293786	15/47 (32%)
		ANK repeat	398..427	CDD:293786	11/28 (39%)
		ANK repeat	431..462	CDD:293786	8/30 (27%)
		Ank_2	436..526	CDD:289560	21/94 (22%)
		ANK repeat	464..494	CDD:293786	9/34 (26%)
		ANK	491..616	CDD:238125	37/126 (29%)
		ANK repeat	496..527	CDD:293786	6/30 (20%)
		Ank_2	501..592	CDD:289560	30/92 (33%)
		ANK repeat	529..560	CDD:293786	11/31 (35%)
		ANK	557..682	CDD:238125	38/124 (31%)
		ANK repeat	562..590	CDD:293786	13/27 (48%)
		Ank_5	582..636	CDD:290568	9/53 (17%)
		ANK repeat	595..625	CDD:293786	5/29 (17%)
		ANK repeat	628..657	CDD:293786	11/28 (39%)
		Ank_2	633..723	CDD:289560	35/112 (31%)
		ANK repeat	661..691	CDD:293786	8/29 (28%)
		ANK	692..812	CDD:238125	43/142 (30%)
		ANK repeat	693..724	CDD:293786	13/53 (25%)
		Ank_2	698..788	CDD:289560	35/89 (39%)
		ANK repeat	726..755	CDD:293786	11/28 (39%)
		ANK repeat	759..788	CDD:293786	14/28 (50%)
		ZU5	930..1034	CDD:128514	16/103 (16%)
		Death_ank	1439..1521	CDD:260029
Tnks	NP_001099554.2	ANK	198..312	CDD:238125	34/113 (30%)
		ANK repeat	208..236	CDD:293786	9/27 (33%)
		Ank_2	210..302	CDD:289560	29/91 (32%)
		ANK repeat	238..269	CDD:293786	9/30 (30%)
		ANK	266..445	CDD:238125	61/186 (33%)
		ANK repeat	271..302	CDD:293786	11/30 (37%)
		Ank_4	329..379	CDD:290365	17/52 (33%)
		ANK repeat	361..389	CDD:293786	15/27 (56%)
		Ank_2	363..455	CDD:289560	37/91 (41%)
		ANK repeat	391..422	CDD:293786	12/30 (40%)
		ANK repeat	424..455	CDD:293786	11/30 (37%)
		ANK	513..629	CDD:238125	37/119 (31%)
		ANK repeat	513..545	CDD:293786	13/31 (42%)
		Ank_2	516..609	CDD:289560	32/92 (35%)
		ANK repeat	547..578	CDD:293786	12/30 (40%)
		ANK repeat	580..609	CDD:293786	8/28 (29%)
		Ank_2	585..704	CDD:289560	32/130 (25%)
		ANK	666..791	CDD:238125	48/158 (30%)
		ANK repeat	676..704	CDD:293786	10/27 (37%)
		Ank_2	678..770	CDD:289560	40/124 (32%)
		ANK repeat	706..737	CDD:293786	13/30 (43%)
		ANK repeat	739..770	CDD:293786	16/63 (25%)
		Ank_4	793..847	CDD:290365	11/53 (21%)
		ANK	819..943	CDD:238125	43/145 (30%)
		ANK repeat	826..857	CDD:293786	12/30 (40%)
		Ank_2	831..923	CDD:289560	35/91 (38%)
		ANK repeat	859..890	CDD:293786	11/30 (37%)
		ANK repeat	892..923	CDD:293786	14/30 (47%)
		SAM_tankyrase1,2	1014..1079	CDD:188923	12/96 (13%)
		SAM	1020..1077	CDD:197735	11/88 (13%)
		tankyrase_like	1081..1303	CDD:238718	29/153 (19%)
		PARP	1095..1298	CDD:279038	27/139 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810