DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank and ANK3

DIOPT Version :10

Sequence 1:NP_787122.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_066267.2 Gene:ANK3 / 288 HGNCID:494 Length:4377 Species:Homo sapiens


Alignment Length:1460 Identity:747/1460 - (51%)
Similarity:995/1460 - (68%) Gaps:110/1460 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 KQNDATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVDICCELLRRGIK 98
            |::||..|:|||||:|.::|.:|::..|  .|||.||.|||||||||:|:|:|::..|||:|...
Human    37 KKSDANASYLRAARAGHLEKALDYIKNG--VDINICNQNGLNALHLASKEGHVEVVSELLQREAN 99

  Fly    99 IDNATKKGNTALHIASLAGQHDVINQLILYNANVNVQSLNGFTPLYMAAQENHDNCCRTLLANGA 163
            :|.|||||||||||||||||.:|:..|:...||||.||.||||||||||||||....:.||.|||
Human   100 VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164

  Fly   164 NPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAKLLLQHDPNAD 228
            :.||:|||||||||||:|||||::|::|||||.:||||||||||||:|:|..||.||||:|.|||
Human   165 SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNAD 229

  Fly   229 IVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKI 293
            :.||||||||||||||||:::||||||..|.|::.|:::|||||||.|.|..::..|||.|||||
Human   230 VESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294

  Fly   294 DAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAP 358
            ||.||||||||||.:||||.:|::.||.:.||||:|||||||.||||.||:|.....|||.:..|
Human   295 DAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVP 359

  Fly   359 VDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGA 423
            ||:||.||||||||||||||.||||:|||.||||||:||||||||||||||||||::|||:||||
Human   360 VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGA 424

  Fly   424 NIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADIIRILLR-S 487
            :|.|.|||||||:|||:|||.:|||..|:.|.||.:...:||||.||:|||:.||:::|.|:: .
Human   425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDG 489

  Fly   488 AKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLEN 552
            |:|:|.|::.|||||:::|||..:|:..|||.||..||.:...|:.||::|:||.|::...||::
Human   490 AQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH 554

  Fly   553 GAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLK 617
            ||..:..|||||||||:|.||||..|..:|||..||.|..||:.:||||||.||:|..:..|||.
Human   555 GASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLD 619

  Fly   618 NGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLL 682
            .|:||:..|:||...:|||.|||.::||..||::|||.|.:::.|.:.:|||||.|:||||.|||
Human   620 QGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL 684

  Fly   683 EYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFF 746
            .... ::.:.|:||||||:||||..|.|:::|:..||::..:|:.||||||:..|||::.:|.|.
Human   685 GRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749

  Fly   747 IENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLGYVTVMES 811
            :::.|.:...:..|||||||||||||..|||:||::.|:||.||.:|||||.||..|||::|:::
Human   750 LQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDT 814

  Fly   812 LKIVTSTSVINSNIGAIEEKLKVMTPELMQETL---------------LSD----SDDESCDDLL 857
            |||||..::..:   .:.||.|:..||.|.|.|               |||    ||.|..:|.:
Human   815 LKIVTEETMTTT---TVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAM 876

  Fly   858 DHNHYKYMATDDLKA--------------NYGQDQKNFDTTNTDHDLTDVSVLNKKEILPNEMSC 908
            ..:..||:...|||.              :.|....:..:.::|...|    ||:.....:.|..
Human   877 TGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYT----LNRSSYARDSMMI 937

  Fly   909 IEL-----------------TEIGHKP------DNVVIARSQVHLGFLVSFLVDARGGSMRGYRH 950
            .||                 ..:.|..      |||.:..|.:|.||||||:||||||||||.||
Human   938 EELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGSMRGSRH 1002

  Fly   951 NGVRIIVPPKACAEPTRITCRYVKPQRVVNPPPLMEGEALVSRILEMSPVDGMFLSPITLEVPHY 1015
            :|:|||:||:.|..|||||||.||..::.||||::|||.|.||::||.|....||.|:.:|:||:
Human  1003 HGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHF 1067

  Fly  1016 GTLRKNEREIIILRSDNGESWREHNL---YKDI------IGEDINQTEEFHSDRIVRIVTQNVPH 1071
            |::|..|||:|:|||:|||:|:||..   .:|:      :.|:::..||....||.||:|::.|.
Human  1068 GSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKDFPQ 1132

  Fly  1072 FFAVVSRVRQEVHVIGPDGGTVFSTAVPQVKAIFPPHALTKKIRVGLQAQSVDLVECSKLLGQGV 1136
            :||||||::||.:.|||:||.:.||.||.|:|.||..||||:||||||||.|......|:||...
Human  1133 YFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKILGNKA 1197

  Fly  1137 AVSPVVTVEPRRRKFHKAITLSIPAPKACTNSMVNACYGNGNSSSPTLRLLCSISGGQTRATWED 1201
            ..||:||||||||||||.||::||.|......:.|...|:   ::|.|||||||:||.:.|.|||
Human  1198 TFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGD---TTPNLRLLCSITGGTSPAQWED 1259

  Fly  1202 VTGSTPLSFVRDSVTFTTTVSARFWLIDCRNIIDAGRMATELYSHLAKVPFYVKFVIFAKRISQT 1266
            :||:|||:|::|.|:|||.|||||||.||..:::...:||:||..|..||:..|||:|||.....
Human  1260 ITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPYMAKFVVFAKMNDPV 1324

  Fly  1267 EAKFSVFCMTDDKEDKTLEQQEYFKEVAKSRDIEVLQNQIVYLEFAGNIVPILKKGEQLYTKFQP 1331
            |:....|||||||.||||||||.|:|||:|:|||||:.:.:|::..||:.|:.|.|:||...|..
Human  1325 ESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYS 1389

  Fly  1332 FCENRLSFSAHIKD--QEFPHGRICFMTYPMVGPDEVPLKPLCTLNISVDFKTITNHLERDNLHS 1394
            |.||||.||..|:|  || |.||:.|:..|.. ...:|...:|.|||:                 
Human  1390 FKENRLPFSIKIRDTSQE-PCGRLSFLKEPKT-TKGLPQTAVCNLNIT----------------- 1435

  Fly  1395 LNDCINAHGKLNHNENIVFGVKEQQVKKID 1424
                :.||.|...::      ::.:::|.|
Human  1436 ----LPAHKKETESD------QDDEIEKTD 1455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_787122.1 ANKYR 20..337 CDD:440430 199/302 (66%)
ANK repeat 72..103 CDD:293786 17/30 (57%)
ANK repeat 105..136 CDD:293786 20/30 (67%)
ANK repeat 138..169 CDD:293786 21/30 (70%)
ANK repeat 204..231 CDD:293786 18/26 (69%)
ANKYR 217..502 CDD:440430 190/285 (67%)
ANK repeat 233..264 CDD:293786 22/30 (73%)
ANK repeat 266..295 CDD:293786 17/28 (61%)
ANK repeat 299..330 CDD:293786 19/30 (63%)
ANK repeat 332..363 CDD:293786 17/30 (57%)
ANK repeat 365..395 CDD:293786 26/29 (90%)
ANK repeat 398..427 CDD:293786 24/28 (86%)
ANK repeat 431..462 CDD:293786 18/30 (60%)
ANK repeat 464..494 CDD:293786 16/30 (53%)
ANK repeat 496..527 CDD:293786 16/30 (53%)
ANKYR 510..797 CDD:440430 143/287 (50%)
ANK repeat 529..560 CDD:293786 11/30 (37%)
ANK repeat 562..590 CDD:293786 18/27 (67%)
ANK repeat 595..625 CDD:293786 15/29 (52%)
ANK repeat 628..657 CDD:293786 15/28 (54%)
ANK repeat 661..691 CDD:293786 14/30 (47%)
ANK repeat 693..724 CDD:293786 15/30 (50%)
ANK repeat 726..755 CDD:293786 12/28 (43%)
ANK repeat 759..788 CDD:293786 20/28 (71%)
ZU5 930..1034 CDD:128514 63/103 (61%)
UPA_2 1250..1378 CDD:375346 64/129 (50%)
Death_ank 1439..1521 CDD:260029
ANK3NP_066267.2 ANKYR 1..305 CDD:440430 177/269 (66%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44 3/6 (50%)
ANK repeat 73..104 CDD:293786 17/30 (57%)
ANK 1 73..102 16/28 (57%)
ANK repeat 106..137 CDD:293786 20/30 (67%)
ANK 2 106..135 19/28 (68%)
ANK 3 139..168 19/28 (68%)
ANK repeat 139..164 CDD:293786 17/24 (71%)
ANK 4 172..201 21/28 (75%)
ANK 5 203..230 19/26 (73%)
ANK repeat 205..232 CDD:293786 18/26 (69%)
ANK repeat 234..265 CDD:293786 22/30 (73%)
ANK 6 234..263 22/28 (79%)
ANKYR 248..536 CDD:440430 179/287 (62%)
ANK repeat 267..298 CDD:293786 19/30 (63%)
ANK 7 267..296 17/28 (61%)
ANK 8 300..329 18/28 (64%)
ANK repeat 300..325 CDD:293786 15/24 (63%)
ANK repeat 333..364 CDD:293786 17/30 (57%)
ANK 9 333..362 16/28 (57%)
ANK 10 366..395 25/28 (89%)
ANK repeat 369..397 CDD:293786 24/27 (89%)
ANK repeat 399..430 CDD:293786 25/30 (83%)
ANK 11 399..428 24/28 (86%)
ANKYR 413..701 CDD:440430 148/287 (52%)
ANK repeat 432..463 CDD:293786 18/30 (60%)
ANK 12 432..461 18/28 (64%)
ANK repeat 465..496 CDD:293786 16/30 (53%)
ANK 13 465..494 15/28 (54%)
ANK repeat 498..529 CDD:293786 16/30 (53%)
ANK 14 498..527 14/28 (50%)
ANK repeat 531..560 CDD:293786 11/28 (39%)
ANK 15 531..560 11/28 (39%)
ANK repeat 564..593 CDD:293786 18/28 (64%)
ANK 16 564..593 18/28 (64%)
ANK repeat 597..626 CDD:293786 15/28 (54%)
ANK 17 597..626 15/28 (54%)
PHA02875 605..>800 CDD:165206 96/194 (49%)
ANK repeat 630..660 CDD:293786 16/29 (55%)
ANK 18 630..659 15/28 (54%)
ANK repeat 663..694 CDD:293786 14/30 (47%)
ANK 19 663..692 14/28 (50%)
ANK repeat 696..727 CDD:293786 15/30 (50%)
ANK 20 696..725 15/28 (54%)
ANK repeat 729..760 CDD:293786 12/30 (40%)
ANK 21 729..758 12/28 (43%)
ANK 22 762..791 20/28 (71%)
ANK repeat 762..790 CDD:293786 19/27 (70%)
ANK 23 795..825 16/29 (55%)
ZU5 982..1086 CDD:128514 63/103 (61%)
UPA domain. /evidence=ECO:0000250 1273..1407 70/133 (53%)
UPA_2 1308..1437 CDD:375346 64/151 (42%)
Herpes_BLLF1 <1393..1770 CDD:282904 24/92 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1519..1540
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1968..1987
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2107..2159
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2176..2245
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2299..2322
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2383..2433
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2474..2508
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2588..2751
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2795..2824
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3036..3067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3131..3272
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3298..3516
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3538..3607
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3635..3718
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3868..3897
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4019..4090
Death_ank3 4088..4171 CDD:176781
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4251..4298
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4323..4377
Blue background indicates that the domain is not in the aligned region.

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