DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank and ANK2

DIOPT Version :9

Sequence 1:NP_001162819.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:NP_001373103.1 Gene:ANK2 / 287 HGNCID:493 Length:4183 Species:Homo sapiens


Alignment Length:1655 Identity:792/1655 - (47%)
Similarity:1060/1655 - (64%) Gaps:197/1655 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 VRVENKIQTRSETCAINGMALDNKNGIIKQ----NDATISFLRAARSGDIKKVMDFLDCGEISDI 66
            :|.:..:|...:|....|...::    :|:    :|:..|||||||:|::.||:::|..|  .||
Human    16 IRAQGNMQELDKTPDYYGCNSED----VKEPGVWSDSNASFLRAARAGNLDKVVEYLKGG--IDI 74

  Fly    67 NSCNANGLNALHLAAKDGYVDICCELLRRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNAN 131
            |:||.|||||||||||:|:|.:..|||.||..:|:|||||||||||||||||.:|:..|:...||
Human    75 NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 139

  Fly   132 VNVQSLNGFTPLYMAAQENHDNCCRTLLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDV 196
            :|.||.||||||||||||||.:..:.||.||||.|.:|||||||||||:||||::.||:|||||.
Human   140 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 204

  Fly   197 RGKVRLPALHIAAKKNDVNAAKLLLQHDPNADIVSK--------SGFTPLHIAAHYGNVDIATLL 253
            :||||||||||||:|:|..:|.||||:|.|||:.||        |||||||||||||||::||||
Human   205 KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 269

  Fly   254 LNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKH 318
            ||..|.|::.|::.|||||||.|.|..::..|||.||.:|||.|||||||||||:||||.:|::.
Human   270 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 334

  Fly   319 LLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAK 383
            ||::.||:|.:||||||.|||||||:|.|....||.:|||||:||:||||||||||||||.:|.|
Human   335 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTK 399

  Fly   384 LLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIV 448
            ||||.:||||||||||||||||||||||||::|||:|:||:|.|.|||||||:|||:|||.:|||
Human   400 LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV 464

  Fly   449 IYLLQHEASADLPTIRGETPLHLAARANQADIIRILLRS-AKVDAIAREGQTPLHVASRLGNINI 512
            :.|||:.||.|:..|||||.||:||||.|.:::|.|||: |.|||.|||.|||||:|||||...|
Human   465 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI 529

  Fly   513 IMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTKKGFTPLHLACKYGKQN 577
            :.|||||.|..:|.:.:.|:.|||:|:|||.::..||||.||.::..|||||||||:|.|||..:
Human   530 VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD 594

  Fly   578 VVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYL 642
            |.::|||..|:.|..|||.:||||||.||:|..:..|||:.|:||:..|:||...:|||.|||.:
Human   595 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 659

  Fly   643 EIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGV-ISAAAKNGLTPLHVAAQEGH 706
            :||..||.:||:.||::|.|.:|||||:|.|:.|||.|||:.|. |..:.|:|||.||:||||..
Human   660 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDK 724

  Fly   707 VLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQG 771
            |.|:.||.:|||:....|:.|||||.:|.|||::.:|.|.::..|::...:..||||||||||||
Human   725 VNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQG 789

  Fly   772 HIMIINLLLRHKANPNALTKDGNTALHIASNLGYVTVMESLKIVTSTSVINSNIGAIEEKLKVMT 836
            |..|||:||:|.|.|||.|.:|||||.||..|||::|:::||:||..  :.:....|.||.|:..
Human   790 HTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEE--VTTTTTTITEKHKLNV 852

  Fly   837 PELMQETL-LSDSD---------------DESCDDLLDHNHYKYMATDDLK-------------- 871
            ||.|.|.| :||.:               .:|.||.:..:..:|:..:|||              
Human   853 PETMTEVLDVSDEEALKQFGDHFIDGEALSDSGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLD 917

  Fly   872 -ANY--------GQDQKNFDTTNTDHDLT------DVSVLNKKEILPN----------EMSCIEL 911
             .||        ..|.....:::..|.|:      |.:|::...::|:          |.:...|
Human   918 GMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRL 982

  Fly   912 TEIGHKPDNVVIARSQVHLG------------FLVSFLVDARGGSMRGYRHNGVRIIVPPKACAE 964
            :......|||.::.|.:|.|            |||||:||||||:|||.||||:|||:||:.|..
Human   983 SWGTENLDNVALSSSPIHSGRASPCLERDNSSFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTA 1047

  Fly   965 PTRITCRYVKPQRVVN---------------------------------PPPLMEGEALVSRILE 996
            |||:|||.||..|:..                                 ||||.|||:||||||:
Human  1048 PTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQ 1112

  Fly   997 MSPVDGMFLSPITLEVPHYGTLRKNEREIIILRSDNGESWREH--NLYKDIIGEDIN-------Q 1052
            :.|....||.|:.:|:||:..||..|||:::|||:||:||:||  :..:|.:.|.:|       .
Human  1113 LGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDS 1177

  Fly  1053 TEEFHSDRIVRIVTQNVPHFFAVVSRVRQEVHVIGPDGGTVFSTAVPQVKAIFPPHALTKKIRVG 1117
            .|:....||.||:|::.|.:||||||::|:.::|||:||.:.||.||||:|:||..||||:||||
Human  1178 PEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVG 1242

  Fly  1118 LQAQSVDLVECSKLLGQGVAVSPVVTVEPRRRKFHKAITLSIPAPKACTNSMVNACYGNGNSSSP 1182
            ||||.:......|:||.....||:||:|||||||||.||::||.|||.::.|:|...|:    :|
Human  1243 LQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGD----AP 1303

  Fly  1183 TLRLLCSISGGQTRATWEDVTGSTPLSFVRDSVTFTTTVSARFWLIDCRNIIDAGRMATELYSHL 1247
            ||||||||:||.|.|.|||:||:|||:||.:.|:|||.|||||||||||.|.::...|:::|..:
Human  1304 TLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREI 1368

  Fly  1248 AKVPFYVKFVIFAKRISQTEAKFSVFCMTDDKEDKTLEQQEYFKEVAKSRDIEVLQNQIVYLEFA 1312
            ..||:..|||:|||.....||:...|||||||.||||||||.|.|||:|||:|||:.:.:|::..
Human  1369 ICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCF 1433

  Fly  1313 GNIVPILKKGEQLYTKFQPFCENRLSFSAHIKD--QEFPHGRICFMTYPMVGPDEVPLKPLCTLN 1375
            ||:||:.|.|:.....|..|.||||.....::|  || |.||:.||..|......|. :.:|.||
Human  1434 GNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQE-PCGRLSFMKEPKSTRGLVH-QAICNLN 1496

  Fly  1376 ISVDFKTITNHLERDNLHSLNDCINAHGKLNHNENIVFGVKEQQVKKIDITKACIMSSDIKLIHE 1440
            |::..  .|...|.|                          ::|.::||:|..   .:|.....|
Human  1497 ITLPI--YTKESESD--------------------------QEQEEEIDMTSE---KNDETESTE 1530

  Fly  1441 ADVILDDICSHLGSDWPLLAN---VLGVSQADIDLVKTEFLLNDSVKQSMAMLQLWLEHGGILTG 1502
            ..|:.    |||.::.|:||:   :..||:...||:|...:|...|...              .|
Human  1531 TSVLK----SHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDVSDK--------------AG 1577

  Fly  1503 NVLAEALYKIGRS------DIVEKSFKNAE 1526
            ::..:.|.|....      :|||:..::.|
Human  1578 SIKVKELVKAAEEEPGEPFEIVERVKEDLE 1607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_001162819.1 ANK 67..192 CDD:238125 84/124 (68%)
ANK repeat 72..103 CDD:293786 19/30 (63%)
Ank_2 77..167 CDD:289560 58/89 (65%)
ANK repeat 105..136 CDD:293786 19/30 (63%)
ANK repeat 138..169 CDD:293786 21/30 (70%)
ANK 204..320 CDD:238125 76/123 (62%)
ANK repeat 204..231 CDD:293786 17/26 (65%)
Ank_2 205..295 CDD:289560 57/97 (59%)
ANK repeat 233..264 CDD:293786 23/30 (77%)
ANK repeat 266..295 CDD:293786 15/28 (54%)
ANK 294..419 CDD:238125 93/124 (75%)
ANK repeat 299..330 CDD:293786 19/30 (63%)
Ank_4 300..353 CDD:290365 33/52 (63%)
ANK repeat 332..363 CDD:293786 20/30 (67%)
Ank_2 337..428 CDD:289560 69/90 (77%)
ANK 360..485 CDD:238125 90/124 (73%)
ANK repeat 365..395 CDD:293786 24/29 (83%)
ANK repeat 398..427 CDD:293786 23/28 (82%)
ANK repeat 431..462 CDD:293786 20/30 (67%)
Ank_2 436..526 CDD:289560 55/90 (61%)
ANK repeat 464..494 CDD:293786 19/30 (63%)
ANK 491..616 CDD:238125 69/124 (56%)
ANK repeat 496..527 CDD:293786 19/30 (63%)
Ank_2 501..592 CDD:289560 48/90 (53%)
ANK repeat 529..560 CDD:293786 14/30 (47%)
ANK 557..682 CDD:238125 67/124 (54%)
ANK repeat 562..590 CDD:293786 16/27 (59%)
Ank_5 582..636 CDD:290568 27/53 (51%)
ANK repeat 595..625 CDD:293786 16/29 (55%)
ANK repeat 628..657 CDD:293786 14/28 (50%)
Ank_2 633..723 CDD:289560 48/90 (53%)
ANK repeat 661..691 CDD:293786 16/30 (53%)
ANK 692..812 CDD:238125 65/119 (55%)
ANK repeat 693..724 CDD:293786 16/30 (53%)
Ank_2 698..788 CDD:289560 47/89 (53%)
ANK repeat 726..755 CDD:293786 12/28 (43%)
ANK repeat 759..788 CDD:293786 21/28 (75%)
ZU5 930..1034 CDD:128514 63/148 (43%)
Death_ank 1439..1521 CDD:260029 21/90 (23%)
ANK2NP_001373103.1 Ank_2 35..>311 CDD:423045 169/281 (60%)
ANK repeat 80..111 CDD:293786 19/30 (63%)
ANK repeat 113..144 CDD:293786 19/30 (63%)
ANK repeat 146..171 CDD:293786 17/24 (71%)
Ank_2 202..>444 CDD:423045 164/241 (68%)
ANK repeat 212..247 CDD:293786 19/34 (56%)
ANK repeat 249..280 CDD:293786 23/30 (77%)
ANK repeat 282..313 CDD:293786 17/30 (57%)
ANK repeat 315..345 CDD:293786 19/29 (66%)
ANK repeat 348..379 CDD:293786 20/30 (67%)
ANK repeat 381..411 CDD:293786 24/29 (83%)
ANK repeat 414..445 CDD:293786 24/30 (80%)
PHA03095 421..>706 CDD:222980 164/284 (58%)
ANK repeat 447..478 CDD:293786 20/30 (67%)
ANK repeat 480..511 CDD:293786 19/30 (63%)
ANK repeat 513..542 CDD:293786 18/28 (64%)
ANK repeat 546..571 CDD:293786 12/24 (50%)
Ank_2 578..>802 CDD:423045 119/223 (53%)
ANK repeat 579..604 CDD:293786 15/24 (63%)
ANK repeat 612..643 CDD:293786 16/30 (53%)
ANK repeat 645..676 CDD:293786 16/30 (53%)
ANK repeat 678..707 CDD:293786 16/28 (57%)
ANK repeat 711..742 CDD:293786 16/30 (53%)
ANK repeat 744..775 CDD:293786 12/30 (40%)
ANK repeat 777..806 CDD:293786 21/28 (75%)
Ank_4 778..830 CDD:372654 35/51 (69%)
ZU5 1013..1150 CDD:128514 62/136 (46%)
UPA_2 1371..1500 CDD:375346 62/130 (48%)
PspC_subgroup_1 1549..>1922 CDD:411407 14/73 (19%)
PTZ00449 <1717..2161 CDD:185628
Streccoc_I_II <1843..>2027 CDD:411384
Spc7_N <2493..>2634 CDD:373822
rad2 <3031..>3565 CDD:273166
PRK14949 <3196..>3442 CDD:237863
Death_ank2 3614..3697 CDD:260066
NESP55 <3770..>3884 CDD:115071
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1011028at2759
OrthoFinder 1 1.000 - - FOG0000917
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100012
Panther 1 1.100 - - O PTHR24133
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1361
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
98.780

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