DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank and ANK1

DIOPT Version :9

Sequence 1:NP_001162819.1 Gene:Ank / 43770 FlyBaseID:FBgn0011747 Length:1549 Species:Drosophila melanogaster
Sequence 2:XP_011542792.1 Gene:ANK1 / 286 HGNCID:492 Length:1969 Species:Homo sapiens


Alignment Length:1610 Identity:722/1610 - (44%)
Similarity:980/1610 - (60%) Gaps:169/1610 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 KQNDATISFLRAARSGDIKKVMDFLDCGEISDINSCN---------------------------- 70
            |:.||..|||||||||::.|.:|.|..|  .|||:||                            
Human    41 KKADAATSFLRAARSGNLDKALDHLRNG--VDINTCNQGPSASAVDLLLRCRISQSTGLLRVLYN 103

  Fly    71 ----ANGLNALHLAAKDGYVDICCELLRRGIKIDNATKKGNTALHIASLAGQHDVINQLILYNAN 131
                .||||.||||:|:|:|.:..|||.:.|.::..|||||||||||:||||.:|:.:|:.|.||
Human   104 QNRKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGAN 168

  Fly   132 VNVQSLNGFTPLYMAAQENHDNCCRTLLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDV 196
            ||.||..|||||||||||||....:.||.||||.:::|||||||||||:||||:.:||.|:....
Human   169 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 233

  Fly   197 RGKVRLPALHIAAKKNDVNAAKLLLQHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNKADVN 261
            :||||||||||||:.:|...|.:|||:|||.|::||:|||||||||||.|:::|.||||..|.||
Human   234 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 298

  Fly   262 YVAKHNITPLHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPI 326
            :..::.|||||:|.:.|.:.:..|||.|||:|:..|:|.|||||||:|:|||.:.:.||...|||
Human   299 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 363

  Fly   327 LTKTKNGLSALHMAAQGEHDEAAHLLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKAN 391
            ..|||||||.:||||||:|.:...|||...|.:|::|:|:||.|||||||||.:|||:|||..|.
Human   364 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 428

  Fly   392 PNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEA 456
            ||:||||||||||||||||.::::|||:|.||:|.|.|||||||||||||||.:.||..|||..|
Human   429 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 493

  Fly   457 SADLPTIRGETPLHLAARANQADIIRILLRS-AKVDAIAREGQTPLHVASRLGNINIIMLLLQHG 520
            |.::..::.|||||:||||...::.:.||:: |||:|.|::.|||||.|:|:|:.|::.|||::.
Human   494 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 558

  Fly   521 AEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQN 585
            |..|..:...::.|||||:||....|..|||..|....:|||||||||:|.||||..|.::||:.
Human   559 ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER 623

  Fly   586 GASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQ 650
            .|..:..|||.:||||||.|:||..||:|||..|.||:..|.||...:|||.|:|.:|:|..|||
Human   624 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 688

  Fly   651 HGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGVISAAA------KNGLTPLHVAAQEGHVLV 709
            :|...|..|..|.:|||||||.|:.:||.|||     |..|      |:||||||:.||||||.|
Human   689 YGGSANAESVQGVTPLHLAAQEGHAEMVALLL-----SKQANGNLGNKSGLTPLHLVAQEGHVPV 748

  Fly   710 SQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIM 774
            :.:|::||..:...||.||||||:|:|||::.||||.:::.||:...:.:||:||||||||||..
Human   749 ADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTD 813

  Fly   775 IINLLLRHKANPNALTKDGNTALHIASNLGYVTVMESLKIVT-STSVINSNIGAIEEKLKVMTPE 838
            |:.|||::.|:||.::.||.|.|.||..|||::|.:.||:|| .||.:     .:.:|.::..||
Human   814 IVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFV-----LVSDKHRMSFPE 873

  Fly   839 LMQETLLSDSDDESCDDLLDHNHYKYMATDDLKANYGQDQKNFDTTNTDHDLTDVSVLNKKEILP 903
            .:.| :|..|:||..      .|...|         |::..:|.....|....|    .:||:|.
Human   874 TVDE-ILDVSEDEGT------AHITIM---------GEELISFKAERRDSRDVD----EEKELLD 918

  Fly   904 ---------------------------------------NEMSCIELTEIGHKPDNVVIARSQVH 929
                                                   :|.|.|..:......||:....|.||
Human   919 FVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVH 983

  Fly   930 LGFLVSFLVDARGGSMRGYRHNGVRIIVPPKACAEPTRITCRYVKPQRVVNPPPLMEGEALVSRI 994
            .||||||:||||||||||.||||:|:::||:.||.|||||||.||||::..||||.|.|.|.|||
Human   984 TGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRI 1048

  Fly   995 LEMSPVDGMFLSPITLEVPHYGTLRKNEREIIILRSDNGESWREH-----NLYKDII----GEDI 1050
            :.:.|....||||:.:|:||:.:..:.:||:::|||:||..|:||     ..|.|.|    .|::
Human  1049 IALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEEL 1113

  Fly  1051 NQTEEFHSDRIVRIVTQNVPHFFAVVSRVRQEVHVIGPDGGTVFSTAVPQVKAIFPPHALTKKIR 1115
            ...||....|:.||:|.:.|.:|.::||:.|:...|||:||::.|..||.|:|.||.:|:||:::
Human  1114 GSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVK 1178

  Fly  1116 VGLQAQSVDLVECSKLLGQGVAVSPVVTVEPRRRKFHKAITLSIPAPKACTNSMVNACYGNGNSS 1180
            :.||||.|.....:||||.....||:|||||||||||:.|.|.||.|.:.|::..::  |.|:::
Human  1179 LALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDS--GEGDTT 1241

  Fly  1181 SPTLRLLCSISGGQTRATWEDVTGSTPLSFVRDSVTFTTTVSARFWLIDCRNIIDAGRMATELYS 1245
            |  ||||||:.||..:|.|||:||:|.|.:..:...|||.|||||||.||....:|...||.||.
Human  1242 S--LRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYK 1304

  Fly  1246 HLAKVPFYVKFVIFAKRISQTEAKFSVFCMTDDKEDKTLEQQEYFKEVAKSRDIEVLQNQIVYLE 1310
            .|..||:..|||||||.....|.:...:||||||.||||||.|.|.|||:|||||||:...::.|
Human  1305 ELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAE 1369

  Fly  1311 FAGNIVPILKKGEQLYTKFQPFCENRLSFSAHIKD-QEFPHGRICFMTYPMVGPDEVPLKPLCTL 1374
            .:||:||:.|..:|....||.|.||||:....::| ...|.|.:.|:...|...|...:  ||.|
Human  1370 LSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHI--LCHL 1432

  Fly  1375 NISVDFKTITNHLERDNLHSLNDCINAHGKLNHNEN-----IVFGVKEQQVKKIDITKACIMSSD 1434
            ||                 ::..|....|..:....     :.:.:..:.      |...:..::
Human  1433 NI-----------------TMPPCAKGSGAEDRRRTPTPLALRYSILSES------TPGSLSGTE 1474

  Fly  1435 IKLIHEADVILDDICSHLGSDWPLLANVLGVSQADIDLVKTEFLLNDSVKQSMAMLQLWLEHGGI 1499
                 :|::.:..|..|||..|..||..|..|..||:.::.| ..|..::||:|:|.||:...| 
Human  1475 -----QAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVE-NPNSLLEQSVALLNLWVIREG- 1532

  Fly  1500 LTGNV--LAEALYKIGRSDIVEKSFKNAEFGTHQPEKVLPTAGIEKDGDY 1547
            ...|:  |..||..|.|.:||     |...|:.:..:.|.......|.||
Human  1533 QNANMENLYTALQSIDRGEIV-----NMLEGSGRQSRNLKPDRRHTDRDY 1577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AnkNP_001162819.1 ANK 67..192 CDD:238125 78/156 (50%)
ANK repeat 72..103 CDD:293786 15/30 (50%)
Ank_2 77..167 CDD:289560 54/89 (61%)
ANK repeat 105..136 CDD:293786 20/30 (67%)
ANK repeat 138..169 CDD:293786 19/30 (63%)
ANK 204..320 CDD:238125 64/115 (56%)
ANK repeat 204..231 CDD:293786 15/26 (58%)
Ank_2 205..295 CDD:289560 50/89 (56%)
ANK repeat 233..264 CDD:293786 20/30 (67%)
ANK repeat 266..295 CDD:293786 14/28 (50%)
ANK 294..419 CDD:238125 77/124 (62%)
ANK repeat 299..330 CDD:293786 17/30 (57%)
Ank_4 300..353 CDD:290365 31/52 (60%)
ANK repeat 332..363 CDD:293786 16/30 (53%)
Ank_2 337..428 CDD:289560 57/90 (63%)
ANK 360..485 CDD:238125 78/124 (63%)
ANK repeat 365..395 CDD:293786 21/29 (72%)
ANK repeat 398..427 CDD:293786 20/28 (71%)
ANK repeat 431..462 CDD:293786 20/30 (67%)
Ank_2 436..526 CDD:289560 45/90 (50%)
ANK repeat 464..494 CDD:293786 15/30 (50%)
ANK 491..616 CDD:238125 61/124 (49%)
ANK repeat 496..527 CDD:293786 14/30 (47%)
Ank_2 501..592 CDD:289560 41/90 (46%)
ANK repeat 529..560 CDD:293786 12/30 (40%)
ANK 557..682 CDD:238125 66/124 (53%)
ANK repeat 562..590 CDD:293786 16/27 (59%)
Ank_5 582..636 CDD:290568 27/53 (51%)
ANK repeat 595..625 CDD:293786 18/29 (62%)
ANK repeat 628..657 CDD:293786 13/28 (46%)
Ank_2 633..723 CDD:289560 46/95 (48%)
ANK repeat 661..691 CDD:293786 15/29 (52%)
ANK 692..812 CDD:238125 64/119 (54%)
ANK repeat 693..724 CDD:293786 16/30 (53%)
Ank_2 698..788 CDD:289560 48/89 (54%)
ANK repeat 726..755 CDD:293786 16/28 (57%)
ANK repeat 759..788 CDD:293786 18/28 (64%)
ZU5 930..1034 CDD:128514 60/103 (58%)
Death_ank 1439..1521 CDD:260029 29/83 (35%)
ANK1XP_011542792.1 ANK 47..163 CDD:238125 49/117 (42%)
ANK repeat 47..75 CDD:293786 16/29 (55%)
ANK 108..229 CDD:238125 75/120 (63%)
ANK repeat 109..140 CDD:293786 15/30 (50%)
Ank_2 114..204 CDD:289560 54/89 (61%)
ANK repeat 143..173 CDD:293786 19/29 (66%)
ANK 170..324 CDD:238125 91/153 (59%)
ANK repeat 175..206 CDD:293786 19/30 (63%)
ANK repeat 208..232 CDD:293786 16/23 (70%)
ANK repeat 241..268 CDD:293786 15/26 (58%)
Ank_2 242..333 CDD:289560 50/90 (56%)
ANK 265..390 CDD:238125 70/124 (56%)
ANK repeat 271..301 CDD:293786 20/29 (69%)
ANK repeat 303..334 CDD:293786 14/30 (47%)
Ank_2 308..397 CDD:289560 47/88 (53%)
ANK repeat 336..367 CDD:293786 17/30 (57%)
ANK repeat 369..400 CDD:293786 16/30 (53%)
Ank 402..432 CDD:278452 21/29 (72%)
ANK repeat 405..433 CDD:293786 19/27 (70%)
ANKYR 406..619 CDD:223738 121/212 (57%)
ANK 430..555 CDD:238125 73/124 (59%)
ANK repeat 435..466 CDD:293786 21/30 (70%)
ANK repeat 468..499 CDD:293786 20/30 (67%)
ANK repeat 501..532 CDD:293786 15/30 (50%)
ANK 529..654 CDD:238125 61/124 (49%)
ANK repeat 534..563 CDD:293786 13/28 (46%)
ANK repeat 568..598 CDD:293786 12/29 (41%)
ANK repeat 600..631 CDD:293786 16/30 (53%)
Ank_2 605..696 CDD:289560 46/90 (51%)
ANK repeat 633..661 CDD:293786 17/27 (63%)
ANK repeat 666..697 CDD:293786 14/30 (47%)
ANK 666..695 CDD:197603 13/28 (46%)
ANK 694..819 CDD:238125 67/129 (52%)
ANK repeat 699..730 CDD:293786 16/35 (46%)
Ank_2 704..795 CDD:289560 49/95 (52%)
ANK repeat 732..763 CDD:293786 16/30 (53%)
ANK repeat 765..796 CDD:293786 16/30 (53%)
Ank_5 785..839 CDD:290568 25/53 (47%)
ANK repeat 798..826 CDD:293786 17/27 (63%)
ZU5 984..1088 CDD:128514 60/103 (58%)
Death_ank1 1474..1557 CDD:260067 30/94 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157945
Domainoid 1 1.000 139 1.000 Domainoid score I4788
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1288 1.000 Inparanoid score I161
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47562
OrthoDB 1 1.010 - - D1011028at2759
OrthoFinder 1 1.000 - - FOG0000917
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100012
Panther 1 1.100 - - LDO PTHR24133
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.770

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