DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank and ANKRD52

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_775866.2	Gene:	ANKRD52 / 283373	HGNCID:	26614	Length:	1076	Species:	Homo sapiens

Alignment Length:	836	Identity:	240/836 - (28%)
Similarity:	376/836 - (44%)	Gaps:	130/836 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SDINSCNANGLNALHLAAKDGYVDICCELLRRGIKIDNATKKGNTALHIASLAGQHDVINQLILY 128
            :|:...:..|...||.||..|.:::...|||.|.:||.....||||||||...||..|..:|:..
Human   197 ADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNA 261

  Fly   129 NANVNVQSLNGFTPLYMAAQENHDNCCRTLLA-NGANPSLSTEDGFTPLAVAMQQGHDKIVAVLL 192
            .||||..:..|||||::||...:...|..||. |||:.:..:::|.:|
Human   262 GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSP----------------- 309

  Fly   193 ENDVRGKVRLPALHIAAKKNDVNAAKLLLQHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLNNK 257
                        ||:||.......:::|:|:....|...|.|.||||:||.||:..:.:.|:.|.
Human   310 ------------LHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNG 362

  Fly   258 ADVNYVAKHNITPLHVACKWGKLSLCTLLLCRG----------------AKIDAATRD--GLTPL 304
            ||......|::.|||:|..:|....|..||..|                |..|..|.|  |.|.|
Human   363 ADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCL 427

  Fly   305 HCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAPVDEVTVDYLTA 369
            |.|:..|:||.:..||...|.:..:.|.|.:.||.||.....:.|..|:...|.|:|......:.
Human   428 HAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSP 492

  Fly   370 LHVAAHCGHVKVA----------------------------KLLLDYKANPNARALNGFTPLHIA 406
            ||.||.....:.|                            :.|||..|:|:.|...|:|.:|.|
Human   493 LHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYA 557

  Fly   407 CKKNRIKMVELLIKHGANIGATTESGL--TPLHVASFMGCINIVIYLLQHEASADLPTIRGETPL 469
            ......:.:|||::...|.....||.:  :|||:|::.|....:..|.:...:.|:...:|.|.|
Human   558 AAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTAL 622

  Fly   470 HLAARANQADIIRILLRSAKVDAIAREGQ---TPLHVASRLGNINIIMLLLQHG--AEINAQSND 529
            .||......:.:.:|.... ..|:.:|.:   ||||.|:..|:.:.:.||:..|  |:| ....|
Human   623 FLATERGSTECVEVLTAHG-ASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADI-TDVMD 685

  Fly   530 KY--SALHIAAKEGQENIVQVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASI--- 589
            .|  :.|.:|...|..:.|.:|||.|:..:|...:|.|.||.....|.::.:..||.:.|.:
Human   686 AYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCR 750

  Fly   590 DFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGAD 654
            ||:|:   ||:|:|:...:.:::..||             |.|           ::...|..|.|
Human   751 DFKGR---TPIHLASACGHTAVLRTLL-------------QAA-----------LSTDPLDAGVD 788

  Fly   655 VNIISKSGFSPLHLAAQGGNVDMVQLLLEYGVISAAAKNGLTPLHVAAQEGHVLVSQILL-EHGA 718
            .     ||:||:|.|:..|:.|.::||||:...|....|..||||.|........:::|| ..||
Human   789 Y-----SGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGA 848

  Fly   719 NI-SERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLL-R 781
            .| :.|...|.||||.||...::..::..:::.|::..:.:.|.|.|..||:.|....:..|| |
Human   849 KIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYR 913

  Fly   782 HKANPNALTKDGNTALHIASNLGYVTVMESLKIVTST---SVINSNIGAIEEKLKV 834
            .||:...|.::.|||||:|.:.|:...  :|.|:..|   .:||:...|::..|.:
Human   914 GKADLTVLDENKNTALHLACSKGHEKC--ALMILAETQDLGLINATNSALQMPLHI 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125	43/125 (34%)
		ANK repeat	72..103	CDD:293786	12/30 (40%)
		Ank_2	77..167	CDD:289560	40/90 (44%)
		ANK repeat	105..136	CDD:293786	16/30 (53%)
		ANK repeat	138..169	CDD:293786	13/31 (42%)
		ANK	204..320	CDD:238125	43/133 (32%)
		ANK repeat	204..231	CDD:293786	7/26 (27%)
		Ank_2	205..295	CDD:289560	32/105 (30%)
		ANK repeat	233..264	CDD:293786	13/30 (43%)
		ANK repeat	266..295	CDD:293786	11/44 (25%)
		ANK	294..419	CDD:238125	42/154 (27%)
		ANK repeat	299..330	CDD:293786	12/32 (38%)
		Ank_4	300..353	CDD:290365	18/52 (35%)
		ANK repeat	332..363	CDD:293786	10/30 (33%)
		Ank_2	337..428	CDD:289560	28/118 (24%)
		ANK	360..485	CDD:238125	34/154 (22%)
		ANK repeat	365..395	CDD:293786	10/57 (18%)
		ANK repeat	398..427	CDD:293786	8/28 (29%)
		ANK repeat	431..462	CDD:293786	8/32 (25%)
		Ank_2	436..526	CDD:289560	25/94 (27%)
		ANK repeat	464..494	CDD:293786	7/29 (24%)
		ANK	491..616	CDD:238125	39/134 (29%)
		ANK repeat	496..527	CDD:293786	12/35 (34%)
		Ank_2	501..592	CDD:289560	29/97 (30%)
		ANK repeat	529..560	CDD:293786	11/32 (34%)
		ANK	557..682	CDD:238125	32/127 (25%)
		ANK repeat	562..590	CDD:293786	8/30 (27%)
		Ank_5	582..636	CDD:290568	14/56 (25%)
		ANK repeat	595..625	CDD:293786	6/29 (21%)
		ANK repeat	628..657	CDD:293786	5/28 (18%)
		Ank_2	633..723	CDD:289560	27/91 (30%)
		ANK repeat	661..691	CDD:293786	13/29 (45%)
		ANK	692..812	CDD:238125	39/122 (32%)
		ANK repeat	693..724	CDD:293786	11/32 (34%)
		Ank_2	698..788	CDD:289560	28/92 (30%)
		ANK repeat	726..755	CDD:293786	8/28 (29%)
		ANK repeat	759..788	CDD:293786	11/29 (38%)
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
ANKRD52	NP_775866.2	ANK 1	7..36
		Ank_4	11..61	CDD:290365
		ANK repeat	11..38	CDD:293786
		ANK	35..193	CDD:238125
		ANK repeat	40..71	CDD:293786
		ANK 2	40..69
		Ank_2	45..170	CDD:289560
		ANK 3	73..102
		ANK repeat	76..104	CDD:293786
		ANK 4	106..135
		ANK repeat	108..137	CDD:293786
		Ank_2	111..203	CDD:289560	1/5 (20%)
		ANK	134..259	CDD:238125	24/61 (39%)
		ANK repeat	139..170	CDD:293786
		ANK 5	139..168
		ANK repeat	172..203	CDD:293786	1/5 (20%)
		ANK 6	172..201		1/3 (33%)
		Ank_2	177..269	CDD:289560	29/71 (41%)
		ANK repeat	205..236	CDD:293786	12/30 (40%)
		ANK 7	205..234		11/28 (39%)
		ANK 8	238..267		15/28 (54%)
		ANK repeat	238..266	CDD:293786	14/27 (52%)
		Ank_2	243..336	CDD:289560	34/121 (28%)
		ANK	266..392	CDD:238125	44/154 (29%)
		ANK 9	271..301		13/29 (45%)
		ANK repeat	272..303	CDD:293786	13/30 (43%)
		ANK repeat	305..336	CDD:293786	9/59 (15%)
		ANK 10	305..334		8/57 (14%)
		ANK	333..476	CDD:238125	47/142 (33%)
		ANK 11	338..367		13/28 (46%)
		ANK repeat	338..363	CDD:293786	11/24 (46%)
		Ank_4	339..392	CDD:290365	20/52 (38%)
		ANK 12	371..400		10/28 (36%)
		ANK repeat	375..420	CDD:293786	12/44 (27%)
		Ank_2	376..486	CDD:289560	34/109 (31%)
		ANK	417..570	CDD:238125	41/152 (27%)
		ANK 13	422..451		11/28 (39%)
		ANK repeat	423..453	CDD:293786	11/29 (38%)
		ANK repeat	455..486	CDD:293786	10/30 (33%)
		ANK 14	455..484		9/28 (32%)
		Ank_2	460..575	CDD:289560	27/114 (24%)
		ANK repeat	488..547	CDD:293786	10/58 (17%)
		ANK 15	488..545		10/56 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..522		1/19 (5%)
		ANK 16	549..579		8/29 (28%)
		ANK 17	584..613		6/28 (21%)
		ANK	587..708	CDD:238125	32/122 (26%)
		ANK repeat	587..615	CDD:293786	7/27 (26%)
		Ank_2	589..682	CDD:289560	25/94 (27%)
		ANK 18	617..646		7/29 (24%)
		ANK repeat	618..648	CDD:293786	7/30 (23%)
		ANK 19	651..680		10/28 (36%)
		ANK repeat	653..685	CDD:293786	11/32 (34%)
		Ank_2	656..751	CDD:289560	28/95 (29%)
		ANK	682..811	CDD:238125	42/160 (26%)
		ANK repeat	687..718	CDD:293786	10/30 (33%)
		ANK 20	687..716		9/28 (32%)
		ANK repeat	720..751	CDD:293786	8/30 (27%)
		ANK 21	720..749		8/28 (29%)
		ANK repeat	753..784	CDD:293786	9/57 (16%)
		ANK 22	753..782		9/55 (16%)
		Ank_2	758..855	CDD:289560	33/125 (26%)
		ANK 23	790..819		13/28 (46%)
		ANK repeat	822..855	CDD:293786	11/32 (34%)
ANK 24	822..852		11/29 (38%)
ANK	852..981	CDD:238125	35/118 (30%)
ANK repeat	857..888	CDD:293786	8/30 (27%)
ANK 25	857..886		8/28 (29%)
Ank_2	862..955	CDD:289560	27/94 (29%)
ANK repeat	890..922	CDD:293786	11/31 (35%)
ANK 26	890..920		11/29 (38%)
ANK repeat	924..991	CDD:293786	14/46 (30%)
ANK 27	924..953		10/30 (33%)
ANK repeat	928..958	CDD:293786	10/31 (32%)
Ank_2	929..1016	CDD:289560	11/41 (27%)
ANK 28	960..989		2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810