DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ank and Ankdd1b

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	XP_006517744.1	Gene:	Ankdd1b / 271144	MGIID:	2444730	Length:	575	Species:	Mus musculus

Alignment Length:	540	Identity:	136/540 - (25%)
Similarity:	225/540 - (41%)	Gaps:	85/540 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 LLLCRGAKI---DAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHD 346
            |...||.|.   |.|||    |....:|....||      |:.........||.|:..:.|.
Mouse    16 LQAARGLKANLRDVATR----PWRSLARMPKPEV------QDPETAAAGHEGLLAIERSFQN--- 67

  Fly   347 EAAHLLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNR 411
                                      ||...::.:.:.|.:.|.|.||......|.||.|..:|.
Mouse    68 --------------------------AAKSSNLDLMEKLFEKKVNINAVNNMNRTALHFAVGRNS 106

  Fly   412 IKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARAN 476
            :..|:.|:.|.|.:....:.|||.:|:|::.|...|::.|::..|........|...|||||:.|
Mouse   107 LSAVDFLLSHKARVDVADKHGLTVIHLAAWSGSFEIMLMLVKAGADQRAKNQEGMNALHLAAQNN 171

  Fly   477 QADIIRILLRSAKVDAIAR---EGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAA 538
            ...|:..|:....:..:.:   .|:.|.|:|:..|::.:|..|:......:.:..|..:|||:||
Mouse   172 NLHIVDYLIHDLHLHDLNQPNERGRKPFHLAAERGHVEMIEKLIFLNLHTSEKDKDGNTALHLAA 236

  Fly   539 KEGQENIVQVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGKNDVTPLHVA 603
            ..|....|||||...:|.|...:.|.||..||...|.:...::||..|:.::...|.:|:.|..|
Mouse   237 MHGHSPAVQVLLTQWSEVNESNENGETPFLLAVVGGHEECSRVLLAGGSDVNIPNKLNVSALQTA 301

  Fly   604 THYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHL 668
            |...:.::|..||...:.......:.:..:|:|...|...:...||....||:::.:...:|||:
Mouse   302 TRNGHTALVNFLLGENADLQQQKESKEPPLHLAVINNRPAVVNSLLSARHDVDVLDQRRQTPLHV 366

  Fly   669 AAQGGNVDMVQLLLEYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLH 732
            ||..|||::|:.||:.|. :....|.|.|.|.|||:..|.||..:|::     :||        :
Mouse   367 AADLGNVELVETLLKAGCNLKITDKQGKTALAVAARSQHSLVVDMLIK-----AER--------Y 418

  Fly   733 MAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQ-AAQQGHIMIINLLLRHKANPN--------A 788
            .|....|.:.::       |..:||.:.:...|. ..:|...::.||..|.....:        :
Mouse   419 YAWREEHRESIQ-------DSAVSSTLTFKQDHSLETRQIRTLLWNLAYRQLKKKDWQRLARLWS 476

  Fly   789 LTKD----------GNTALH 798
            .|:|          ||.:.|
Mouse   477 FTEDQIRAIEEQWSGNDSFH 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125
		ANK repeat	72..103	CDD:293786
		Ank_2	77..167	CDD:289560
		ANK repeat	105..136	CDD:293786
		ANK repeat	138..169	CDD:293786
		ANK	204..320	CDD:238125	12/37 (32%)
		ANK repeat	204..231	CDD:293786
		Ank_2	205..295	CDD:289560	4/12 (33%)
		ANK repeat	233..264	CDD:293786
		ANK repeat	266..295	CDD:293786	4/12 (33%)
		ANK	294..419	CDD:238125	26/124 (21%)
		ANK repeat	299..330	CDD:293786	5/30 (17%)
		Ank_4	300..353	CDD:290365	9/52 (17%)
		ANK repeat	332..363	CDD:293786	4/30 (13%)
		Ank_2	337..428	CDD:289560	17/90 (19%)
		ANK	360..485	CDD:238125	33/124 (27%)
		ANK repeat	365..395	CDD:293786	6/29 (21%)
		ANK repeat	398..427	CDD:293786	9/28 (32%)
		ANK repeat	431..462	CDD:293786	9/30 (30%)
		Ank_2	436..526	CDD:289560	22/92 (24%)
		ANK repeat	464..494	CDD:293786	9/29 (31%)
		ANK	491..616	CDD:238125	36/127 (28%)
		ANK repeat	496..527	CDD:293786	7/30 (23%)
		Ank_2	501..592	CDD:289560	28/90 (31%)
		ANK repeat	529..560	CDD:293786	14/30 (47%)
		ANK	557..682	CDD:238125	34/124 (27%)
		ANK repeat	562..590	CDD:293786	9/27 (33%)
		Ank_5	582..636	CDD:290568	12/53 (23%)
		ANK repeat	595..625	CDD:293786	7/29 (24%)
		ANK repeat	628..657	CDD:293786	7/28 (25%)
		Ank_2	633..723	CDD:289560	30/90 (33%)
		ANK repeat	661..691	CDD:293786	12/30 (40%)
		ANK	692..812	CDD:238125	28/126 (22%)
		ANK repeat	693..724	CDD:293786	11/30 (37%)
		Ank_2	698..788	CDD:289560	20/98 (20%)
		ANK repeat	726..755	CDD:293786	3/28 (11%)
		ANK repeat	759..788	CDD:293786	5/37 (14%)
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
Ankdd1b	XP_006517744.1	PHA02876	<63..>413	CDD:165207	102/378 (27%)
		ANK repeat	93..124	CDD:293786	9/30 (30%)
		ANK repeat	126..157	CDD:293786	9/30 (30%)
		ANK repeat	163..192	CDD:293786	8/28 (29%)
		ANK repeat	194..225	CDD:293786	7/30 (23%)
		ANK repeat	227..258	CDD:293786	14/30 (47%)
		ANK repeat	260..291	CDD:293786	9/30 (30%)
		ANK repeat	293..321	CDD:293786	7/27 (26%)
		ANK repeat	330..357	CDD:293786	7/26 (27%)
		ANK repeat	359..390	CDD:293786	12/30 (40%)
		DD	466..>508	CDD:387368	5/31 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810