DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ank and Ankrd65

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_001357751.1	Gene:	Ankrd65 / 242805	MGIID:	2685285	Length:	364	Species:	Mus musculus

Alignment Length:	459	Identity:	117/459 - (25%)
Similarity:	186/459 - (40%)	Gaps:	139/459 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 LHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLS 335
            |..|..||..||...||.:|:.::.....|.||||.|...||..:::.|||:.|
Mouse    37 LFQAVWWGAPSLVMQLLRQGSSVEERDHTGRTPLHLAVMRGHAPLVRLLLQRGA----------- 90

  Fly   336 ALHMAAQGEHDEAAHLLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGF 400
               :|...:|...                   |.||.||..||..||
Mouse    91 ---LAGAPDHTGR-------------------TPLHEAAWHGHSNVA------------------ 115

  Fly   401 TPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMG-CINIVIYLLQHEASADLPTIR 464
                           |||::.||:..|.:::||||||.|:.:| .:.:..:.:..::.:|:..:|
Mouse   116 ---------------ELLLRRGASAAACSQTGLTPLHGAAALGRTLLVTSFTVASDSGSDVKDVR 165

  Fly   465 GETPLHLAARANQADIIRILLRSAKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSND 529
            |.|..|.||...|..::.:|......|.   :|  .|.|::..|:.:.:.|||..||:::.|.:.
Mouse   166 GWTAAHWAAACGQLAVLELLSAGGNADL---DG--ALLVSAIAGSTSSLQLLLTLGAKVDTQDST 225

  Fly   530 KYSALHIAAKEGQENIVQVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQGK 594
            ..:||.:||..|....::|||::||:
Mouse   226 GATALGLAAGLGHHQDIEVLLDHGAD--------------------------------------- 251

  Fly   595 NDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIIS 659
                                       ||:..||.:.|:|.|....:|.:...|:..|.:::...
Mouse   252 ---------------------------PNIRDRNNRSALHRAATGGHLRVTQLLVAKGIEIDAQD 289

  Fly   660 KSGFSPLHLAAQGGNVDMVQLLLEYGV-ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISER 723
            ..|.:|||.||:||:|::|..||:.|. |:||.....||||:|.:.||....::||..|||.:.|
Mouse   290 SLGLTPLHHAARGGHVEVVSHLLDRGAHINAAGWLHKTPLHLAVENGHSTTVELLLSRGANSTLR 354

  Fly   724 TRNG 727
            |:.|
Mouse   355 TQWG 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125
		ANK repeat	72..103	CDD:293786
		Ank_2	77..167	CDD:289560
		ANK repeat	105..136	CDD:293786
		ANK repeat	138..169	CDD:293786
		ANK	204..320	CDD:238125	17/48 (35%)
		ANK repeat	204..231	CDD:293786
		Ank_2	205..295	CDD:289560	9/23 (39%)
		ANK repeat	233..264	CDD:293786
		ANK repeat	266..295	CDD:293786	9/23 (39%)
		ANK	294..419	CDD:238125	25/124 (20%)
		ANK repeat	299..330	CDD:293786	12/30 (40%)
		Ank_4	300..353	CDD:290365	14/52 (27%)
		ANK repeat	332..363	CDD:293786	2/30 (7%)
		Ank_2	337..428	CDD:289560	16/90 (18%)
		ANK	360..485	CDD:238125	31/125 (25%)
		ANK repeat	365..395	CDD:293786	9/29 (31%)
		ANK repeat	398..427	CDD:293786	5/28 (18%)
		ANK repeat	431..462	CDD:293786	9/31 (29%)
		Ank_2	436..526	CDD:289560	23/90 (26%)
		ANK repeat	464..494	CDD:293786	9/29 (31%)
		ANK	491..616	CDD:238125	21/124 (17%)
		ANK repeat	496..527	CDD:293786	9/30 (30%)
		Ank_2	501..592	CDD:289560	19/90 (21%)
		ANK repeat	529..560	CDD:293786	10/30 (33%)
		ANK	557..682	CDD:238125	20/124 (16%)
		ANK repeat	562..590	CDD:293786	0/27 (0%)
		Ank_5	582..636	CDD:290568	6/53 (11%)
		ANK repeat	595..625	CDD:293786	2/29 (7%)
		ANK repeat	628..657	CDD:293786	7/28 (25%)
		Ank_2	633..723	CDD:289560	33/90 (37%)
		ANK repeat	661..691	CDD:293786	15/30 (50%)
		ANK	692..812	CDD:238125	15/36 (42%)
		ANK repeat	693..724	CDD:293786	12/30 (40%)
		Ank_2	698..788	CDD:289560	13/30 (43%)
		ANK repeat	726..755	CDD:293786	1/2 (50%)
		ANK repeat	759..788	CDD:293786
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
Ankrd65	NP_001357751.1	ANK repeat	33..63	CDD:293786	9/25 (36%)
		PHA03095	49..>347	CDD:222980	105/434 (24%)
		ANK repeat	65..96	CDD:293786	13/44 (30%)
		ANK repeat	98..123	CDD:293786	12/76 (16%)
		ANK repeat	165..223	CDD:293786	18/62 (29%)
		ANK repeat	226..256	CDD:293786	12/95 (13%)
		ANK repeat	258..289	CDD:293786	7/30 (23%)
		ANK repeat	291..320	CDD:293786	14/28 (50%)
		ANK repeat	324..354	CDD:293786	12/29 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900