DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ank and Ankle1

DIOPT Version :9

Sequence 1:	NP_001162819.1	Gene:	Ank / 43770	FlyBaseID:	FBgn0011747	Length:	1549	Species:	Drosophila melanogaster
Sequence 2:	NP_766344.2	Gene:	Ankle1 / 234396	MGIID:	1918775	Length:	534	Species:	Mus musculus

Alignment Length:	466	Identity:	95/466 - (20%)
Similarity:	145/466 - (31%)	Gaps:	173/466 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 LHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAPVDEVTVDYLT 368
            |..|.|......::.||:..|.......:|.:|:|:||:..|..|.|.|
Mouse    11 LLAALREEEARAVEELLRLGADPNLVLDDGAAAVHLAARASHPRALHCL---------------- 59

  Fly   369 ALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGL 433
                          ::||.:.|:||||:..|.||:|:|........:|||:..|.:.....:.||
Mouse    60 --------------RMLLRWGADPNARSAEGLTPVHVAAAWGCCGALELLLSRGGDPTLRDQDGL 110

  Fly   434 TPLHVA---SFMGCINIVIYLLQHEASADLPTIRGET-----PLHLAARANQADIIR--ILLRSA 488
            .||..|   ....|..::..|       |.||...||     ..|:|..:.:.:..:  .|..|:
Mouse   111 RPLDWALQQRHHNCARVLQEL-------DTPTQPDETREPTETFHVAQGSFETETCQGPALAESS 168

  Fly   489 KVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQEN--------- 544
            .|..     .:.|||               |.||:..::.:  .|:|..:.|..||
Mouse   169 GVSQ-----DSELHV---------------HRAELEVEAVE--VAVHPQSSEATENSDYSSDASF 211

  Fly   545 --IVQVLLENGAENNA--------VTKKGFTPLHLACKYGKQNVVQILLQNGASID---FQGKND 596
              .|:..|:.|....|        ||:...:    |.|.......|:|.......|   ..|..|
Mouse   212 VTAVEDSLQPGRPGGALELVAGLWVTRGAVS----AGKGAPNCQPQVLTLTARDTDKPVLPGDGD 272

  Fly   597 VTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKS 661
            :..||  .|.:.|.:.:|                                ||||      .:...
Mouse   273 LGALH--PHSSVPPMSDL--------------------------------QLLQ------ALRAL 297

  Fly   662 GFSPLHLAAQGGNVDMVQLLLEYGVISAAAKNGLTPLHVAAQEGHVL-------VSQILLEHGAN 719
            |:||                           ..:||.    ..||.|       .|:..:.|...
Mouse   298 GYSP---------------------------GPVTPF----TRGHYLRRLQEAQASRADVGHSQE 331

  Fly   720 ISERTRNGYTP 730
            ::|..|.|..|
Mouse   332 LAEALRTGTIP 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank	NP_001162819.1	ANK	67..192	CDD:238125
		ANK repeat	72..103	CDD:293786
		Ank_2	77..167	CDD:289560
		ANK repeat	105..136	CDD:293786
		ANK repeat	138..169	CDD:293786
		ANK	204..320	CDD:238125	3/15 (20%)
		ANK repeat	204..231	CDD:293786
		Ank_2	205..295	CDD:289560
		ANK repeat	233..264	CDD:293786
		ANK repeat	266..295	CDD:293786
		ANK	294..419	CDD:238125	29/114 (25%)
		ANK repeat	299..330	CDD:293786	6/25 (24%)
		Ank_4	300..353	CDD:290365	14/48 (29%)
		ANK repeat	332..363	CDD:293786	9/30 (30%)
		Ank_2	337..428	CDD:289560	23/90 (26%)
		ANK	360..485	CDD:238125	30/134 (22%)
		ANK repeat	365..395	CDD:293786	5/29 (17%)
		ANK repeat	398..427	CDD:293786	9/28 (32%)
		ANK repeat	431..462	CDD:293786	8/33 (24%)
		Ank_2	436..526	CDD:289560	20/99 (20%)
		ANK repeat	464..494	CDD:293786	7/36 (19%)
		ANK	491..616	CDD:238125	29/146 (20%)
		ANK repeat	496..527	CDD:293786	6/30 (20%)
		Ank_2	501..592	CDD:289560	22/112 (20%)
		ANK repeat	529..560	CDD:293786	9/49 (18%)
		ANK	557..682	CDD:238125	22/135 (16%)
		ANK repeat	562..590	CDD:293786	4/27 (15%)
		Ank_5	582..636	CDD:290568	9/56 (16%)
		ANK repeat	595..625	CDD:293786	6/29 (21%)
		ANK repeat	628..657	CDD:293786	4/28 (14%)
		Ank_2	633..723	CDD:289560	14/96 (15%)
		ANK repeat	661..691	CDD:293786	3/29 (10%)
		ANK	692..812	CDD:238125	11/46 (24%)
		ANK repeat	693..724	CDD:293786	8/37 (22%)
		Ank_2	698..788	CDD:289560	9/40 (23%)
		ANK repeat	726..755	CDD:293786	2/5 (40%)
		ANK repeat	759..788	CDD:293786
		ZU5	930..1034	CDD:128514
		Death_ank	1439..1521	CDD:260029
Ankle1	NP_766344.2	ANK 1. /evidence=ECO:0000255	4..35		6/23 (26%)
		ANK	26..128	CDD:238125	34/131 (26%)
		Ank_2	26..106	CDD:289560	28/109 (26%)
		ANK 2. /evidence=ECO:0000255	39..71		13/61 (21%)
		ANK repeat	75..106	CDD:293786	9/30 (30%)
		ANK 3. /evidence=ECO:0000255	75..104		9/28 (32%)
		Ank_4	76..128	CDD:290365	15/51 (29%)
		ANK 4. /evidence=ECO:0000255	108..137		10/35 (29%)
		LEM	285..322	CDD:295412	13/105 (12%)
		GIY-YIG_COG3680_Meta	372..484	CDD:198401
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q8NAG6	498..505
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900